# STOCKHOLM 1.0 #=GF ID 3.30.230.10/FF/27599 #=GF DE DNA topoisomerase 2 #=GF AC 3.30.230.10/FF/27599 #=GF TP FunFam #=GF DR CATH: 4.2 #=GF DR DOPS: 63.977 #=GS P12531/268-389 AC P12531 #=GS P12531/268-389 OS Trypanosoma brucei brucei #=GS P12531/268-389 DE DNA topoisomerase 2 #=GS P12531/268-389 DR GENE3D; e77d84baab228a1498bf09a321e14252/268-389; #=GS P12531/268-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS P12531/268-389 DR GO; GO:0005739; #=GS P12531/268-389 DR EC; 5.99.1.3; #=GS Q9XZN0/266-389 AC Q9XZN0 #=GS Q9XZN0/266-389 OS Leishmania donovani #=GS Q9XZN0/266-389 DE DNA topoisomerase 2 #=GS Q9XZN0/266-389 DR GENE3D; 0e7cdd976f2b0902ffd5c11dd8aaad35/266-389; #=GS Q9XZN0/266-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; #=GS Q9XZN0/266-389 DR EC; 5.99.1.3; #=GS A4HWL4/266-389 AC A4HWL4 #=GS A4HWL4/266-389 OS Leishmania infantum #=GS A4HWL4/266-389 DE DNA topoisomerase 2 #=GS A4HWL4/266-389 DR GENE3D; 0f093423c0c3d9f4bd53c2f087811e6f/266-389; #=GS A4HWL4/266-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; #=GS A4HWL4/266-389 DR EC; 5.99.1.3; #=GS E9BCH0/266-389 AC E9BCH0 #=GS E9BCH0/266-389 OS Leishmania donovani BPK282A1 #=GS E9BCH0/266-389 DE DNA topoisomerase 2 #=GS E9BCH0/266-389 DR GENE3D; 2d041d91325a5ccfe85e6c65ad2bdee3/266-389; #=GS E9BCH0/266-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; #=GS E9BCH0/266-389 DR EC; 5.99.1.3; #=GS E9AQC1/266-383 AC E9AQC1 #=GS E9AQC1/266-383 OS Leishmania mexicana MHOM/GT/2001/U1103 #=GS E9AQC1/266-383 DE DNA topoisomerase 2 #=GS E9AQC1/266-383 DR GENE3D; 881c59609b85d3e4beeb425bbcfa60e2/266-383; #=GS E9AQC1/266-383 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; #=GS E9AQC1/266-383 DR EC; 5.99.1.3; #=GS Q9NAS4/266-389 AC Q9NAS4 #=GS Q9NAS4/266-389 OS Leishmania infantum #=GS Q9NAS4/266-389 DE DNA topoisomerase 2 #=GS Q9NAS4/266-389 DR GENE3D; 896be8e6aa980a15b99be613182d3f5d/266-389; #=GS Q9NAS4/266-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; #=GS Q9NAS4/266-389 DR EC; 5.99.1.3; #=GS A4H891/266-383 AC A4H891 #=GS A4H891/266-383 OS Leishmania braziliensis #=GS A4H891/266-383 DE DNA topoisomerase 2 #=GS A4H891/266-383 DR GENE3D; c006ff0dc7570b2c6fc72a81be22a404/266-383; #=GS A4H891/266-383 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Viannia; Leishmania braziliensis species complex; Leishmania braziliensis; #=GS A4H891/266-383 DR EC; 5.99.1.3; #=GS A0A088RLN4/266-385 AC A0A088RLN4 #=GS A0A088RLN4/266-385 OS Leishmania panamensis #=GS A0A088RLN4/266-385 DE DNA topoisomerase 2 #=GS A0A088RLN4/266-385 DR GENE3D; c92bf281f733d4a04eb9bca5bba18bd1/266-385; #=GS A0A088RLN4/266-385 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Viannia; Leishmania guyanensis species complex; Leishmania panamensis; #=GS A0A088RLN4/266-385 DR EC; 5.99.1.3; #=GS A0A1E1IS39/266-385 AC A0A1E1IS39 #=GS A0A1E1IS39/266-385 OS Leishmania guyanensis #=GS A0A1E1IS39/266-385 DE DNA topoisomerase 2 #=GS A0A1E1IS39/266-385 DR GENE3D; c92bf281f733d4a04eb9bca5bba18bd1/266-385; #=GS A0A1E1IS39/266-385 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Viannia; Leishmania guyanensis species complex; Leishmania guyanensis; #=GS A0A1E1IS39/266-385 DR EC; 5.99.1.3; #=GS Q4QF53/266-383 AC Q4QF53 #=GS Q4QF53/266-383 OS Leishmania major #=GS Q4QF53/266-383 DE DNA topoisomerase 2 #=GS Q4QF53/266-383 DR GENE3D; cf73684445e2bb8b7febfd52581ae297/266-383; #=GS Q4QF53/266-383 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; #=GS Q4QF53/266-383 DR EC; 5.99.1.3; #=GS O61078/266-390 AC O61078 #=GS O61078/266-390 OS Leishmania chagasi #=GS O61078/266-390 DE DNA topoisomerase 2 #=GS O61078/266-390 DR GENE3D; ea264fa252986720c60ed28b10b65584/266-390; #=GS O61078/266-390 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania chagasi; #=GS O61078/266-390 DR EC; 5.99.1.3; #=GS A0A1G4I7P1/268-389 AC A0A1G4I7P1 #=GS A0A1G4I7P1/268-389 OS Trypanosoma equiperdum #=GS A0A1G4I7P1/268-389 DE DNA topoisomerase 2 #=GS A0A1G4I7P1/268-389 DR GENE3D; 2a7262a2d628885bf46db84866ccda74/268-389; #=GS A0A1G4I7P1/268-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; #=GS A0A1G4I7P1/268-389 DR EC; 5.99.1.3; #=GS Q38EZ6/268-389 AC Q38EZ6 #=GS Q38EZ6/268-389 OS Trypanosoma brucei brucei TREU927 #=GS Q38EZ6/268-389 DE DNA topoisomerase 2 #=GS Q38EZ6/268-389 DR GENE3D; 2a7262a2d628885bf46db84866ccda74/268-389; #=GS Q38EZ6/268-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; #=GS Q38EZ6/268-389 DR EC; 5.99.1.3; #=GS H8XX08/265-378 AC H8XX08 #=GS H8XX08/265-378 OS Trypanosoma rangeli #=GS H8XX08/265-378 DE DNA topoisomerase 2 #=GS H8XX08/265-378 DR GENE3D; 5f44498c66aec5ce5ad910880bb68f68/265-378; #=GS H8XX08/265-378 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Herpetosoma; Trypanosoma rangeli; #=GS H8XX08/265-378 DR EC; 5.99.1.3; #=GS P27570/267-379 AC P27570 #=GS P27570/267-379 OS Crithidia fasciculata #=GS P27570/267-379 DE DNA topoisomerase 2 #=GS P27570/267-379 DR GENE3D; 29ca7741b55bbc0012b8df59bcff2919/267-379; #=GS P27570/267-379 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Crithidia; Crithidia fasciculata; #=GS P27570/267-379 DR EC; 5.99.1.3; #=GS Q4DHG5/265-371 AC Q4DHG5 #=GS Q4DHG5/265-371 OS Trypanosoma cruzi strain CL Brener #=GS Q4DHG5/265-371 DE DNA topoisomerase 2 #=GS Q4DHG5/265-371 DR GENE3D; 8ff0e805036f7ae9b942f10ad3e38a5f/265-371; #=GS Q4DHG5/265-371 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Schizotrypanum; Trypanosoma cruzi; #=GS Q4DHG5/265-371 DR EC; 5.99.1.3; #=GS C9ZXS6/268-389 AC C9ZXS6 #=GS C9ZXS6/268-389 OS Trypanosoma brucei gambiense DAL972 #=GS C9ZXS6/268-389 DE DNA topoisomerase 2 #=GS C9ZXS6/268-389 DR GENE3D; 5d4cb3d3deafa2352f295f790712f851/268-389; #=GS C9ZXS6/268-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei gambiense; #=GS C9ZXS6/268-389 DR EC; 5.99.1.3; #=GS A0A061J3Y5/265-378 AC A0A061J3Y5 #=GS A0A061J3Y5/265-378 OS Trypanosoma rangeli SC58 #=GS A0A061J3Y5/265-378 DE DNA topoisomerase 2 #=GS A0A061J3Y5/265-378 DR GENE3D; b3e38ae11829a58f876bb07a926a0f98/265-378; #=GS A0A061J3Y5/265-378 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Herpetosoma; Trypanosoma rangeli; #=GS A0A061J3Y5/265-378 DR EC; 5.99.1.3; #=GS P30190/265-378 AC P30190 #=GS P30190/265-378 OS Trypanosoma cruzi #=GS P30190/265-378 DE DNA topoisomerase 2 #=GS P30190/265-378 DR GENE3D; 4ee69323a1d897f36f5a1a5851334462/265-378; #=GS P30190/265-378 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Schizotrypanum; Trypanosoma cruzi; #=GS P30190/265-378 DR EC; 5.99.1.3; #=GS S9VL19/267-378 AC S9VL19 #=GS S9VL19/267-378 OS Strigomonas culicis #=GS S9VL19/267-378 DE DNA topoisomerase 2 #=GS S9VL19/267-378 DR GENE3D; 7053cc38107490a01139738b0bf837d6/267-378; #=GS S9VL19/267-378 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Strigomonadinae; Strigomonas; Strigomonas culicis; #=GS S9VL19/267-378 DR EC; 5.99.1.3; #=GS F9W9A3/266-389 AC F9W9A3 #=GS F9W9A3/266-389 OS Trypanosoma congolense IL3000 #=GS F9W9A3/266-389 DE DNA topoisomerase 2 #=GS F9W9A3/266-389 DR GENE3D; fd7f6354db90ad7aa34378b1667d7c2a/266-389; #=GS F9W9A3/266-389 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Nannomonas; Trypanosoma congolense; #=GS F9W9A3/266-389 DR EC; 5.99.1.3; #=GS Q4E0W1/265-373 AC Q4E0W1 #=GS Q4E0W1/265-373 OS Trypanosoma cruzi strain CL Brener #=GS Q4E0W1/265-373 DE DNA topoisomerase 2 #=GS Q4E0W1/265-373 DR GENE3D; 95a8f3311d77a7481969e5f841fe681d/265-373; #=GS Q4E0W1/265-373 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Schizotrypanum; Trypanosoma cruzi; #=GS Q4E0W1/265-373 DR EC; 5.99.1.3; #=GS Q6Y3N7/267-378 AC Q6Y3N7 #=GS Q6Y3N7/267-378 OS Strigomonas culicis #=GS Q6Y3N7/267-378 DE DNA topoisomerase 2 #=GS Q6Y3N7/267-378 DR GENE3D; 8f58ef4c148a1ca65a647a800401dbf2/267-378; #=GS Q6Y3N7/267-378 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Strigomonadinae; Strigomonas; Strigomonas culicis; #=GS Q6Y3N7/267-378 DR EC; 5.99.1.3; #=GS V5BUD4/265-378 AC V5BUD4 #=GS V5BUD4/265-378 OS Trypanosoma cruzi Dm28c #=GS V5BUD4/265-378 DE DNA topoisomerase 2 #=GS V5BUD4/265-378 DR GENE3D; 7007bf3b615e1e02073ca28a991c4f89/265-378; #=GS V5BUD4/265-378 DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Schizotrypanum; Trypanosoma cruzi; #=GS V5BUD4/265-378 DR EC; 5.99.1.3; #=GF TC 211.6 2.1E-66 #=GF SQ 24 P12531/268-389 ----SKSGCVAFIPSVVPGVRRMFGVVNGVVTYNGGTHCNAAQDILTGCLDGVERELKKENKVMDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSTPTMPRVPRQDVMKYLLRMPFLEAHVSTIT Q9XZN0/266-389 FVYTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTMPRVPKNTLEKYLERMPFLEAHVNS-- A4HWL4/266-389 FVYTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTMPRVPKNTLEKYLERMPFLEAHVNS-- E9BCH0/266-389 FVYTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTMPRVPKNTLEKYLERMPFLEAHVNS-- E9AQC1/266-383 FVYTSSNGSVAYVPQLTQSPKRIVSVVNGVVTYNGGTHCNAAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLVQAQPKFDSQSKARLVSTVTMPRVPKNTLEKYLERMPFL-------- Q9NAS4/266-389 FVYTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTMPRVPKNTLEKYLERMPFLEAHVNS-- A4H891/266-383 FVHTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAIDILDSCLDSLSRNFKKEGKVVDTNRVQRHFTVLVFLIQAQPKFDSQSKARLVSTVTMPRVPKNTLEKYLETMPFL-------- A0A088RLN4/266-385 FVHTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAIDILDSCLDSLSRNFKKEGKVVDTNRVQRHFTVLVFLIQAQPKFDSQSKARLVSTVTMPRVPKNTLEKYLEKMPFLEA------ A0A1E1IS39/266-385 FVHTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAIDILDSCLDSLSRNFKKEGKVVDTNRVQRHFTVLVFLIQAQPKFDSQSKARLVSTVTMPRVPKNTLEKYLEKMPFLEA------ Q4QF53/266-383 FVYTSPNGSVAYVPQLTQSPKRIVSVVNGVVTYNGGTHCNAAMDILDACLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLVQAQPKFDSQSKARLVSTVTMPRVPKNTLEKYLERMPFL-------- O61078/266-390 FVYTSPNGSVAYVPQLTQSPKRIVGVVNGVVTYNGGTHCNAAMDILDSCLDSLSKNFKKNGKVVDTNRVQRHFTVLVFLIQTQPKFDSQSKARLVSTVTMPRMPKNTLEKYLERMPFLEAHVNSM- A0A1G4I7P1/268-389 ----SKSGCVAFIPSVVPGVRRMFGVVNGVVTYNGGTHCNAAQDILTGCLDGVERELKKENKVMDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSTPTMPRVPRQDVMKYLLRMPFLEAHVSTIT Q38EZ6/268-389 ----SKSGCVAFIPSVVPGVRRMFGVVNGVVTYNGGTHCNAAQDILTGCLDGVERELKKENKVMDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSTPTMPRVPRQDVMKYLLRMPFLEAHVSTIT H8XX08/265-378 -VYESRNGAIAFVPSLTAGIRRIFSVVNGVVTHNGGTHCNAAQDILQSSLEYVERALKKENKVIDTNRVLRHFTILVFLVQVQPRFDSQNKARLVSAPTMPRVPSQELTEFLLRM----------- P27570/267-379 -VHTGPNGSIAFVPQLTQSPKRIVGVVNGVVTYNGGTHCTSAMEILETGLDSLSRSLKKDGKVIDTNRVARHFTVLVFLIQSQPKFDSQSKARLVSTVTMPRVPRTALDQYLAA------------ Q4DHG5/265-371 -VYESRNGAIAFIPSLTAGTRRIFGVVNGVVTHNGGTHCNAAQEVLQSSLENVEKALKKDNKVIDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSVPTMPRVPRQEL------------------ C9ZXS6/268-389 ----SKSGCVAFIPSVVPGVRRMFGVVNGVVTYNGGTHCNAAQDILTGCLDGVERELKKENKVMDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSTPTMPRVPRQDVMKYLLRMPFLEAHVSTIT A0A061J3Y5/265-378 -VYESRNGAIAFVPSLTAGIRRIFSVVNGVVTHNGGTHCNAAQDILQSSLEYVERALKKENKVIDTNRVLRHFTILVFLVQVQPRFDSQNKARLVSAPTMPRVPRQELTEFLLRM----------- P30190/265-378 -VYESRNGAIAFIPSLTAGTRRIFGVVNGVVTHNGGTHCNAAQEVLQSSLESVEKALKKDNKVIDTNRVLRHFMILVFLVQVQPKFDSQNKARLVSVPTMPRVPRQELMDFLLRM----------- S9VL19/267-378 -VHNSRNGSIAFVPQLNAGAKRIFGVVNGVVTHNGGTHCNAASDILTGTLDALSRTLKKDGKVVDANRVMRHFTILVFLIQSQPKFDSQSKARLVSTVTMPRVPKGELEQYLS------------- F9W9A3/266-389 --YESRSGCVAFIPSVTPGVRRMFGVVNGVVTYNGGTHCNAAQEILVGCLDGVEKELKKENKVMDSNRVLRHFTILVFLVQVQPKFDSQNKARLISAPTMPRVPRQDVMKYLLRMPFLESHVSTIT Q4E0W1/265-373 -VYESRNGAIAFIPSLTAGTRRIFGVVNGVVTHNGGTHCNAAQEVLQSSLENVEKALKKDNKVIDTNRVLRHFTILVFLVQVQPKFDSQNKARLVSVPTMPRVPKQELMD---------------- Q6Y3N7/267-378 -VHNSRNGSIAFVPQLNAGAKRIFGVVNGVVTHNGGTHCNAASDILTGTLDALSRTLKKDGKVVDANRVMRHFTILVFLIQSQPKFDSQSKARLVSTVTMPRVPKGELEQYLS------------- V5BUD4/265-378 -VYESRNGAIAFIPSLTAGTRRIFGVVNGVVTHNGGTHCNAAQEVLQSSLESVEKALKKDNKVIDTNRVLRHFMILVFLVQVQPKFDSQNKARLVSVPTMPRVPRQELMDFLLRM----------- #=GC scorecons 154384795797795764647975799999997999999889477945597465746995599697999499987999979599899996999989659999896547456734533321110000 #=GC scorecons_70 ____*_**_*****_**___***_******************_***___**_*_*_***__**_*****_***********_*******_******__*******__*__**______________ #=GC scorecons_80 ____*__*__**_*_*_____**_******************_***___**______**__**_*****_****_****_*_*******_******__******___*___*______________ #=GC scorecons_90 ____*__*__*__*_______*___*******_*********___*___*_______**__**_*_***_***__****_*_*******_******__******______________________ //