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CATH Superfamily 3.30.1490.120

RNA polymerase Rpb7-like, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
RNA polymerase Rpb7-like, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 299: DNA-directed RNA polymerase II subunit rpb7

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-directed RNA polymerase. [EC: 2.7.7.6]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized.
  • See also EC 2.7.7.19 and EC 2.7.7.48.
 14 A0A061IC43 B3MXA0 B3P0R9 B4GMM3 B4HE07 B4JGB3 B4KAG6 B4LY27 B4NBB5 B4PS78
(4 more...)
Signal peptidase I. [EC: 3.4.21.89]
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
  • Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity.
  • Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein, producing free signal peptide and coat protein.
  • Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane and mitochondrial inner membrane.
  • Belongs to peptidase family S26.
  • Formerly EC 3.4.99.36.
 3 A0A0R3RZ67 A0A182EKB6 A0A1I7VXW6
Histone-lysine N-methyltransferase. [EC: 2.1.1.43]
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
    		 1 E0VC46
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