The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120825: Tryptophan synthase alpha chain

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tryptophan synthase. [EC: 4.2.1.20]
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O.
  • The alpha-subunit catalyzes the conversion of 1-C-(indol-3- yl)glycerol 3-phosphate to indole and D-glyceraldehyde 3-phosphate (this reaction was listed formerly as EC 4.1.2.8).
  • The indole migrates to the beta-subunit where, in the presence of pyridoxal 5'-phosphate, it is combined with L-serine to form L-tryptophan.
  • In some organisms this enzyme is part of a multifunctional protein that also includes one or more of the enzymes EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27 and EC 5.3.1.24.
  • In thermophilic organisms, where the high temperature enhances diffusion and causes the loss of indole, a protein similar to the beta subunit can be found (EC 4.2.1.122).
  • That enzyme cannot combine with the alpha unit of EC 4.2.1.20 to form a complex.
25358 A0A009EQI9 A0A009EQI9 A0A009G8H6 A0A009G8H6 A0A009HFC6 A0A009HFC6 A0A009HHL2 A0A009HHL2 A0A009IB76 A0A009IB76
(25348 more...)
Indole-3-glycerol-phosphate lyase. [EC: 4.1.2.8]
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate.
  • Forms part of the defense mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyzes one of the steps in the formation of the cyclic hydroxamic acids 2,4- dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7- methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA).
  • Resembles the alpha-subunit of EC 4.2.1.20 but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released.
24 A0A178UX50 A0A178UX50 C0P7Z2 C0P7Z2 I0B5S8 I0B5S8 K4JEK0 K4JEK0 M4PV41 M4PV41
(14 more...)
Phosphoribosylanthranilate isomerase. [EC: 5.3.1.24]
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate.
  • In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27, and EC 4.2.1.20).
6 A0A0P0L8T0 A0A0P0L8T0 A0A174C9V3 A0A174C9V3 K6AFB6 K6AFB6
Indole-3-glycerol-phosphate synthase. [EC: 4.1.1.48]
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
  • In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20, and EC 5.3.1.24).
2 A0A086ZWJ4 A0A086ZWJ4