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CATH Superfamily 3.20.20.140

Metal-dependent hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 40792: Cytosine deaminase protein

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cytosine deaminase. [EC: 3.5.4.1]
Cytosine + H(2)O = uracil + NH(3).
  • Also acts on 5-methylcytosine.
 1198 A0A009S014 A0A010TAY9 A0A014MEN2 A0A017IKU4 A0A022KXA9 A0A023C7V8 A0A023CA51 A0A023V3E3 A0A023WPG9 A0A023YST3
(1188 more...)
Transferred entry: 3.5.4.42. [EC: 3.5.99.4]
    		37 A0A073JR01 A0A085U6Z6 A0A0E1NXQ5 A0A0H2XWQ3 A0A0H2YMU3 A0A0H3AX20 A0A0H3NXD4 A0A154SL31 A0A1B7LUE1 A4JNH8
    (27 more...)
    N-isopropylammelide isopropylaminohydrolase. [EC: 3.5.4.42]
    N-isopropylammelide + H(2)O = cyanuric acid + isopropylamine.
    • This bacterial enzyme is involved in degradation of the herbicide atrazine.
    • It can hydrolyze other N-substituted amino dihydroxy-s-triazine molecules, and prefers substrates with linear N-alkyl groups to those with branched alkyl groups.
    • Formerly EC 3.5.99.4.
    		 1 A0A1D7ZZG7
    Cytidine deaminase. [EC: 3.5.4.5]
    (1) Cytidine + H(2)O = uridine + NH(3). (2) 2'-deoxycytidine + H(2)O = 2'-deoxyuridine + NH(3).
    • Catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficiencies.
    • The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
    • Formerly EC 3.5.4.14.
    		 1 G8Q551
    Transferred entry: 3.5.4.43. [EC: 3.5.99.3]
      		1 A0A0M1UTU7
      Pterin deaminase. [EC: 3.5.4.11]
      A 2-amino-4-hydroxypteridine + H(2)O = a 2,4-dihydroxypteridine + NH(3).
      • The animal enzyme is specific for pterin, isoxanthopterin and tetrahydropterin.
      		 1 A0A1D7ZZG7
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