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CATH Superfamily 3.15.10.20

Activator of Hsp90 ATPase Aha1, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Activator of Hsp90 ATPase Aha1, N-terminal domain

This superfamily is represented by the activator of Hsp90 (heat shock protein 90) domain which is usually located at the N-terminus. It consists of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP90 and stimulate its ATPase activity.

INTERPRO:IPR015310

GO Diversity

Unique GO annotations
12 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
1154 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 7
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 2
Unique GO: 12
Taxonomy
Unique Species: 1154