The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Alpha carbonic anhydrase

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1430: Alpha carbonic anhydrase 3

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carbonic anhydrase. [EC:]
H(2)CO(3) = CO(2) + H(2)O.
  • The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH.
  • It is widespread and found in archaea, bacteria, and eukaryotes.
  • Three distinct classes exist, and appear to have evolved independently.
820 A0A009F7I8 A0A011NAQ1 A0A011NYQ4 A0A011PUS7 A0A011Q4S7 A0A011RJ28 A0A024RBW9 A0A031GAS1 A0A031GXM4 A0A060I7Z0
(810 more...)
Protein-tyrosine-phosphatase. [EC:]
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
  • Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC
21 A0A0Q3PGR3 A0A151MKI6 A0A151MKJ0 A0A151PEL5 A0A151PEN6 A0A1A7ZRS8 A0A1A8HVC8 A0A1A8PX45 A0A1A8U6N6 A0A1D5PMB2
(11 more...)
DNA topoisomerase (ATP-hydrolyzing). [EC:]
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
  • Can introduce negative superhelical turns into double-stranded circular DNA.
  • One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC
3 A0A078HBW5 A0A078JC34 M4EJ31
Monodehydroascorbate reductase (NADH). [EC:]
NADH + 2 monodehydroascorbate = NAD(+) + 2 ascorbate.
    1 Q84UV8