The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16271: Guanine nucleotide exchange factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 36 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
8 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO) Q8CHG7 (/ISO)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
7 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO)
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
7 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
7 B7Z025 (/ISS) B7Z026 (/ISS) F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9VMF3 (/ISS)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.
7 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 F1M386 (/IPI) F1MSG6 (/IPI) F1PBJ0 (/IPI) Q8TEU7 (/IPI) Q9Y4G8 (/IPI)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
5 B7Z025 (/IDA) B7Z026 (/IDA) Q8CHG7 (/IDA) Q9VMF3 (/IDA) Q9Y4G8 (/IDA)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
3 B7Z025 (/IPI) B7Z026 (/IPI) Q9VMF3 (/IPI)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
3 F1M386 (/IMP) Q8CHG7 (/IMP) Q9Y4G8 (/IMP)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
2 F1MSG6 (/IDA) Q9Y4G8 (/IDA)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
2 Q8TEU7 (/IDA) Q9Y4G8 (/IDA)
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 Q9Y4G8 (/TAS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8TEU7 (/IDA)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q9Y4G8 (/IDA)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8CHG7 (/IMP)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8CHG7 (/ISO)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q9Y4G8 (/TAS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q9Y4G8 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q8CHG7 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9Y4G8 (/NAS)
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
1 Q8TEU7 (/IDA)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8CHG7 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 F1M386 (/IPI)
Diacylglycerol binding GO:0019992
Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.
1 Q9Y4G8 (/NAS)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q9Y4G8 (/IDA)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q8CHG7 (/ISO)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.
1 Q8TEU7 (/IDA)
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
1 Q9Y4G8 (/IDA)
Beta-1 adrenergic receptor binding GO:0031697
Interacting selectively and non-covalently with a beta-1 adrenergic receptor.
1 Q8CHG7 (/ISO)
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
1 Q9Y4G8 (/IDA)
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
1 Q8CHG7 (/ISO)

There are 115 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microvillus assembly GO:0030033
Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
8 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO) Q8CHG7 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
8 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO) Q8CHG7 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
8 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO) Q8CHG7 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
7 B7Z025 (/ISS) B7Z026 (/ISS) F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9VMF3 (/ISS)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Ventricular system development GO:0021591
The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
Forebrain neuron development GO:0021884
The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
Brain-derived neurotrophic factor receptor signaling pathway GO:0031547
The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Nerve growth factor signaling pathway GO:0038180
A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
4 F1M386 (/IMP) Q8CHG7 (/IMP) Q8TEU7 (/IMP) Q9Y4G8 (/IMP)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Negative regulation of melanin biosynthetic process GO:0048022
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Cellular response to cGMP GO:0071321
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Regulation of cell junction assembly GO:1901888
Any process that modulates the frequency, rate or extent of cell junction assembly.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Positive regulation of vasculogenesis GO:2001214
Any process that activates or increases the frequency, rate or extent of vasculogenesis.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q9Y4G8 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
3 B7Z025 (/IGI) B7Z026 (/IGI) Q9VMF3 (/IGI)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
3 B7Z025 (/IGI) B7Z026 (/IGI) Q9VMF3 (/IGI)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Imaginal disc-derived male genitalia development GO:0007485
The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Adherens junction assembly GO:0034333
The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
3 B7Z025 (/IGI) B7Z026 (/IGI) Q9VMF3 (/IGI)
Hemocyte migration GO:0035099
The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
3 F1M386 (/IDA) Q8CHG7 (/IDA) Q9Y4G8 (/IDA)
Regulation of compound eye photoreceptor development GO:0045314
Any process that modulates the frequency, rate or extent of compound eye photoreceptor development.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
3 B7Z025 (/IMP) B7Z026 (/IMP) Q9VMF3 (/IMP)
Negative regulation of dendrite morphogenesis GO:0050774
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
Positive regulation of dendritic cell apoptotic process GO:2000670
Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.
3 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q8CHG7 (/IDA) Q9Y4G8 (/IDA)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
2 Q8CHG7 (/IDA) Q9Y4G8 (/IDA)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
2 Q8CHG7 (/IDA) Q9Y4G8 (/IDA)
Microvillus assembly GO:0030033
Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.
2 Q8TEU7 (/IGI) Q9Y4G8 (/IGI)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
2 Q8CHG7 (/IDA) Q9Y4G8 (/IDA)
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
2 Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q8CHG7 (/IDA) Q9Y4G8 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 F1M386 (/IMP) Q8CHG7 (/IMP)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
2 Q8CHG7 (/IDA) Q9Y4G8 (/IDA)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
2 Q8TEU7 (/IMP) Q9Y4G8 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q9Y4G8 (/NAS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q9Y4G8 (/TAS)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
1 Q8CHG7 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q8CHG7 (/IMP)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q8CHG7 (/ISO)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
1 Q8CHG7 (/ISO)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 Q9Y4G8 (/TAS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 Q8TEU7 (/NAS)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9Y4G8 (/IDA)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8CHG7 (/IMP)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8CHG7 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 F1M386 (/IMP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 Q8CHG7 (/ISO)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 Q9Y4G8 (/NAS)
Ventricular system development GO:0021591
The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
1 Q8CHG7 (/IMP)
Forebrain neuron development GO:0021884
The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
1 Q8CHG7 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q9Y4G8 (/IDA)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q8CHG7 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q8CHG7 (/ISO)
Brain-derived neurotrophic factor receptor signaling pathway GO:0031547
The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.
1 F1M386 (/IMP)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
1 Q8CHG7 (/IDA)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
1 Q9Y4G8 (/IMP)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
1 Q8CHG7 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q9Y4G8 (/TAS)
Nerve growth factor signaling pathway GO:0038180
A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 F1M386 (/IDA)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
1 Q8TEU7 (/NAS)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q9Y4G8 (/IDA)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q8CHG7 (/ISO)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
1 F1M386 (/IMP)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
1 Q8CHG7 (/ISO)
Negative regulation of melanin biosynthetic process GO:0048022
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
1 Q8CHG7 (/IMP)
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 F1M386 (/IDA)
Negative regulation of dendrite morphogenesis GO:0050774
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.
1 Q9Y4G8 (/IDA)
Negative regulation of dendrite morphogenesis GO:0050774
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.
1 Q8CHG7 (/IMP)
Negative regulation of dendrite morphogenesis GO:0050774
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.
1 Q8CHG7 (/ISO)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 Q9Y4G8 (/IMP)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 Q8CHG7 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q8CHG7 (/ISO)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q8CHG7 (/IMP)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q8CHG7 (/ISO)
Cellular response to cGMP GO:0071321
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.
1 Q9Y4G8 (/IDA)
Cellular response to cGMP GO:0071321
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.
1 Q8CHG7 (/ISO)
Adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 Q9Y4G8 (/IDA)
Adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 Q8CHG7 (/ISO)
Establishment of endothelial intestinal barrier GO:0090557
The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 Q9Y4G8 (/IMP)
Establishment of endothelial intestinal barrier GO:0090557
The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 Q8CHG7 (/ISO)
Regulation of cell junction assembly GO:1901888
Any process that modulates the frequency, rate or extent of cell junction assembly.
1 Q9Y4G8 (/IMP)
Regulation of cell junction assembly GO:1901888
Any process that modulates the frequency, rate or extent of cell junction assembly.
1 Q8CHG7 (/ISO)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 F1M386 (/IDA)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 Q9Y4G8 (/IDA)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 Q8CHG7 (/IMP)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 Q8CHG7 (/ISO)
Positive regulation of dendritic cell apoptotic process GO:2000670
Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.
1 Q9Y4G8 (/IDA)
Positive regulation of dendritic cell apoptotic process GO:2000670
Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.
1 Q8CHG7 (/IMP)
Positive regulation of dendritic cell apoptotic process GO:2000670
Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.
1 Q8CHG7 (/ISO)
Positive regulation of vasculogenesis GO:2001214
Any process that activates or increases the frequency, rate or extent of vasculogenesis.
1 Q8CHG7 (/IMP)
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
1 Q8CHG7 (/IMP)

There are 38 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO) Q8CHG7 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
8 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO) Q8CHG7 (/ISO)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
8 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO) Q8CHG7 (/ISO)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
7 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 B2RUJ6 (/ISO) Q562E3 (/ISO) Q5DTR1 (/ISO) Q5NCJ0 (/ISO) Q5NCJ1 (/ISO) Q5NCJ4 (/ISO) Q5NCJ5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
4 F1M386 (/ISS) F1MSG6 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS) Q9Y4G8 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 F1M386 (/ISS) F1MSG6 (/ISS) F1PBJ0 (/ISS) Q8CHG7 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 E9PCH4 (/IDA) Q8TEU7 (/IDA) Q9Y4G8 (/IDA)
Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
3 B7Z025 (/IDA) B7Z026 (/IDA) Q9VMF3 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 E9PCH4 (/IDA) Q8TEU7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 F1M386 (/IDA) Q8TEU7 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q8TEU7 (/IDA) Q9Y4G8 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
2 Q8TEU7 (/IDA) Q9Y4G8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Y4G8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8CHG7 (/ISO)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q9Y4G8 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q8CHG7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Y4G8 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9Y4G8 (/NAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 F1PBJ0 (/IDA)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
1 Q9Y4G8 (/IDA)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
1 Q8CHG7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9Y4G8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8CHG7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8CHG7 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 F1M386 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 F1M386 (/IDA)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
1 F1M386 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 F1M386 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q9Y4G8 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q8CHG7 (/ISO)