The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 154: Signal transducer and activator of transcription

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 62 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0000983
Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 B0JYL6 (/IPI) P40763 (/IPI) P42224 (/IPI) P42225 (/IPI) P42227 (/IPI) P42228 (/IPI) P52630 (/IPI) P52631 (/IPI) Q14765 (/IPI) Q9PVX8 (/IPI)
(2 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
9 A7LH49 (/IPI) B5X3E8 (/IPI) B9UYM8 (/IPI) C0PUF7 (/IPI) C7EY83 (/IPI) P40763 (/IPI) P52631 (/IPI) X2KK07 (/IPI) X2KN52 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
7 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q7ZXK3 (/ISS) Q9PVX8 (/ISS)
STAT family protein binding GO:0097677
Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.
7 A7LH49 (/IPI) B5X3E8 (/IPI) B9UYM8 (/IPI) C0PUF7 (/IPI) C7EY83 (/IPI) X2KK07 (/IPI) X2KN52 (/IPI)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
7 A7LH49 (/IPI) B5X3E8 (/IPI) B9UYM8 (/IPI) C0PUF7 (/IPI) C7EY83 (/IPI) X2KK07 (/IPI) X2KN52 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
6 F1M9D6 (/IDA) P42227 (/IDA) P42228 (/IDA) P52631 (/IDA) Q66HB2 (/IDA) Q9PVX8 (/IDA)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 F1M9D6 (/IDA) P42227 (/IDA) P42228 (/IDA) P52631 (/IDA) Q66HB2 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
5 F1M9D6 (/TAS) P40763 (/TAS) P52631 (/TAS) Q14765 (/TAS) Q66HB2 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 A7LH49 (/IDA) B5X3E8 (/IDA) C7EY83 (/IDA) P42224 (/IDA) P42227 (/IDA)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
4 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
3 P40763 (/IDA) P42224 (/IDA) P42228 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
3 P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
CCR5 chemokine receptor binding GO:0031730
Interacting selectively and non-covalently with a CCR5 chemokine receptor.
3 F1M9D6 (/IPI) P52631 (/IPI) Q66HB2 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P40763 (/IPI) P42224 (/IPI) P52630 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P42225 (/ISO) P42227 (/ISO) Q9WVL2 (/ISO)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
2 P42225 (/ISO) P42227 (/ISO)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 P40763 (/IDA) P42224 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 P42225 (/IMP) P42227 (/IMP)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
2 P42225 (/ISO) P42227 (/ISO)
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2 P40763 (/TAS) P52630 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
2 P42227 (/ISS) Q6DV79 (/ISS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P42227 (/IPI) Q9PVX8 (/IPI)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
2 F1M9D6 (/IPI) Q66HB2 (/IPI)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
1 P42224 (/IDA)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
1 P42225 (/ISO)
RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 P42227 (/IDA)
Transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0000983
Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 P42224 (/IDA)
Transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0000983
Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 P42225 (/ISO)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P42228 (/IC)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P40763 (/IMP)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P42227 (/ISO)
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
1 P40763 (/IPI)
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
1 P42227 (/ISO)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P40763 (/IDA)
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228
Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P42227 (/ISO)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P42224 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P42225 (/ISO)
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
1 P40763 (/IDA)
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
1 P42227 (/ISO)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
1 P42224 (/IPI)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
1 P42225 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 P42227 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P42224 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P42225 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P40763 (/IPI)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P42227 (/ISO)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
1 P40763 (/IDA)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
1 P42227 (/ISO)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 P42224 (/IPI)
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
1 P42225 (/ISO)
Glucocorticoid receptor binding GO:0035259
Interacting selectively and non-covalently with a glucocorticoid receptor.
1 P52631 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P42225 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q7ZXK3 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P40763 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P42227 (/ISO)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P42224 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P42225 (/ISO)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
1 P42227 (/IPI)

There are 239 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
21 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(11 more)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136
The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Metanephric mesenchymal cell differentiation GO:0072162
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
Negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308
Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.
17 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(7 more)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
15 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(5 more)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
15 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(5 more)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
15 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS)
(5 more)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
15 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(5 more)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
7 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) F1M9D6 (/IMP) O93599 (/IMP) Q66HB2 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
7 F1M9D6 (/TAS) P40763 (/TAS) P42227 (/TAS) P52630 (/TAS) P52631 (/TAS) Q14765 (/TAS) Q66HB2 (/TAS)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
7 A7LH49 (/IDA) B5X3E8 (/IDA) B9UYM8 (/IDA) C0PUF7 (/IDA) C7EY83 (/IDA) X2KK07 (/IDA) X2KN52 (/IDA)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
7 A7LH49 (/IMP) B5X3E8 (/IMP) B9UYM8 (/IMP) C0PUF7 (/IMP) C7EY83 (/IMP) X2KK07 (/IMP) X2KN52 (/IMP)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
7 A7LH49 (/IDA) B5X3E8 (/IDA) B9UYM8 (/IDA) C0PUF7 (/IDA) C7EY83 (/IDA) X2KK07 (/IDA) X2KN52 (/IDA)
Cellular response to type I interferon GO:0071357
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
7 A7LH49 (/IDA) B5X3E8 (/IDA) B9UYM8 (/IDA) C0PUF7 (/IDA) C7EY83 (/IDA) X2KK07 (/IDA) X2KN52 (/IDA)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Eye photoreceptor cell differentiation GO:0001754
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Sexual reproduction GO:0019953
A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
6 P42225 (/ISS) P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q764M5 (/ISS)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Regeneration GO:0031099
The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).
5 A0A0R4IGF2 (/IGI) C0SPC7 (/IGI) O93599 (/IGI) Q6NV46 (/IGI) Q7ZTS5 (/IGI)
Posterior lateral line neuromast hair cell development GO:0035677
The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Inner ear receptor cell development GO:0060119
The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Cardiac muscle tissue regeneration GO:0061026
The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
5 A0A0R4IGF2 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
4 P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
4 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
4 B0S789 (/IMP) Q8JFS5 (/IMP) Q8JFS5 (/IMP) Q8JFU8 (/IMP)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
4 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Cellular response to leptin stimulus GO:0044320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
4 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
4 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P40763 (/IDA) P42224 (/IDA) P42227 (/IDA) Q9PVX8 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P40763 (/IDA) P42224 (/IDA) P42227 (/IDA) P42228 (/IDA)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
4 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Radial glial cell differentiation GO:0060019
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
4 O02799 (/ISS) P42224 (/ISS) Q764M5 (/ISS) Q9WVL2 (/ISS)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
4 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 E2RLW2 (/ISS) P42224 (/ISS) P42225 (/ISS)
Positive regulation of mesenchymal cell proliferation GO:0002053
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
3 E2RLW2 (/ISS) P42224 (/ISS) P42225 (/ISS)
Negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340
Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
3 E2RLW2 (/ISS) P42224 (/ISS) P42225 (/ISS)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
3 F1M9D6 (/IEP) P52631 (/IEP) Q66HB2 (/IEP)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
3 F1M9D6 (/IDA) P52631 (/IDA) Q66HB2 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P40763 (/IMP) P42224 (/IMP) P42228 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
3 P42225 (/IMP) P52630 (/IMP) Q9WVL2 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
2 O02799 (/ISS) Q9WVL2 (/ISS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P40763 (/TAS) P52630 (/TAS)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
2 F1M9D6 (/IMP) Q66HB2 (/IMP)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 P42227 (/IDA) P42228 (/IDA)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Macrophage derived foam cell differentiation GO:0010742
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
2 P42225 (/ISS) Q764M5 (/ISS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P42225 (/IDA) P42228 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P40763 (/NAS) P42227 (/NAS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
2 P40763 (/IDA) P42227 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 F1M9D6 (/IEP) Q66HB2 (/IEP)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
2 P40763 (/IDA) P42227 (/IDA)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
2 P40763 (/IMP) P42224 (/IMP)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
2 P42225 (/ISO) P42227 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P40763 (/IMP) P42227 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P42225 (/ISO) P42227 (/ISO)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P40763 (/IGI) P42227 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P42225 (/ISO) P42227 (/ISO)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
2 F1M9D6 (/IMP) Q66HB2 (/IMP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 O02799 (/ISS) Q9WVL2 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
2 P40763 (/IDA) P42227 (/IDA)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
2 F1M9D6 (/IMP) Q66HB2 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 P42224 (/TAS) P52630 (/TAS)
Regulation of type I interferon-mediated signaling pathway GO:0060338
Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
2 P42224 (/TAS) P52630 (/TAS)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
2 P40763 (/IDA) P42227 (/IDA)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
2 P42225 (/TAS) P42227 (/TAS)
Renal tubule development GO:0061326
The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
2 E2RLW2 (/IMP) P42224 (/IMP)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
2 P42225 (/ISO) P42227 (/ISO)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
2 P42225 (/ISO) P42227 (/ISO)
Regulation of mitochondrial fission GO:0090140
Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
2 O02799 (/ISS) Q9WVL2 (/ISS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P40763 (/TAS)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
1 P42227 (/IMP)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
1 Q9PVX8 (/IMP)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
1 Q7ZXK3 (/ISS)
Eye photoreceptor cell differentiation GO:0001754
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
1 P42227 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 P52630 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 Q9WVL2 (/ISO)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
1 P42224 (/IMP)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
1 P42225 (/ISO)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P42225 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P40763 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P42227 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P42227 (/NAS)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P42227 (/IDA)
Transcription from RNA polymerase II promoter GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 Q6DV79 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P42228 (/IDA)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 P40763 (/IDA)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 P42227 (/ISO)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 P42225 (/IMP)
Movement of cell or subcellular component GO:0006928
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
1 P40763 (/TAS)
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
1 P52631 (/IEP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P42227 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P40763 (/TAS)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
1 P42224 (/IDA)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
1 P42225 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P40763 (/TAS)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P52631 (/IEP)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P52631 (/IMP)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P42227 (/IGI)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P42225 (/IDA)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P52631 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P40763 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P42227 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P40763 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P42227 (/ISO)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
1 P52631 (/IMP)
Macrophage derived foam cell differentiation GO:0010742
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
1 P42224 (/IDA)
Macrophage derived foam cell differentiation GO:0010742
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
1 P42225 (/ISO)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
1 Q9PVX8 (/IMP)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
1 Q7ZXK3 (/ISS)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 P42227 (/IDA)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P42224 (/IMP)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P42225 (/ISO)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
1 P42227 (/IMP)
Sexual reproduction GO:0019953
A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
1 P42227 (/IMP)
Intracellular receptor signaling pathway GO:0030522
Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.
1 P40763 (/IDA)
Intracellular receptor signaling pathway GO:0030522
Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.
1 P42227 (/ISO)
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
1 P42225 (/IDA)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P40763 (/IDA)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P52631 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P42227 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P42225 (/IDA)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P40763 (/IDA)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P42227 (/ISO)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P42224 (/IDA)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P42225 (/ISO)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
1 P42227 (/IMP)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
1 P42227 (/ISO)
Negative regulation of macrophage fusion GO:0034240
Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion.
1 P42225 (/IMP)
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P42225 (/IDA)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
1 P40763 (/TAS)
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
1 P40763 (/IDA)
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
1 P42227 (/ISO)
Response to interferon-beta GO:0035456
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
1 P42224 (/IMP)
Response to interferon-beta GO:0035456
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
1 P42225 (/ISO)
Cellular response to interferon-beta GO:0035458
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
1 P42224 (/IMP)
Cellular response to interferon-beta GO:0035458
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
1 P42225 (/ISO)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 P42227 (/IMP)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 Q6DV79 (/ISS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P52631 (/IEP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P42227 (/IMP)
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
1 P42227 (/IMP)
MRNA transcription from RNA polymerase II promoter GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
1 P42227 (/IDA)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 P42224 (/TAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P40763 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P42227 (/ISO)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 P42224 (/IMP)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 P42225 (/ISO)
Response to exogenous dsRNA GO:0043330
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
1 P42225 (/IDA)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P52631 (/IEP)
Cellular response to leptin stimulus GO:0044320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
1 P40763 (/IDA)
Cellular response to leptin stimulus GO:0044320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
1 P42227 (/ISO)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
1 P42227 (/IMP)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
1 P42227 (/ISO)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P52631 (/IEP)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
1 P42227 (/IMP)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
1 P42227 (/IMP)
Negative regulation by virus of viral protein levels in host cell GO:0046725
Any process where the infecting virus reduces the levels of viral proteins in a cell.
1 P42224 (/IMP)
Negative regulation by virus of viral protein levels in host cell GO:0046725
Any process where the infecting virus reduces the levels of viral proteins in a cell.
1 P42225 (/ISO)
Regulation of mitochondrial membrane permeability GO:0046902
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
1 P52631 (/IMP)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
1 P42227 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 P52630 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q9WVL2 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 P42227 (/ISO)
Phospholipid homeostasis GO:0055091
Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
1 Q6GU23 (/IMP)
Radial glial cell differentiation GO:0060019
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 P42227 (/IMP)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
1 P42227 (/IMP)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 P42224 (/IDA)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 P42225 (/IMP)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 P42225 (/ISO)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 P42224 (/TAS)
Regulation of interferon-gamma-mediated signaling pathway GO:0060334
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
1 P42224 (/TAS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 Q9WVL2 (/ISO)
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 P40763 (/IDA)
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 P42227 (/ISO)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
1 P42227 (/ISO)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P52631 (/IMP)
Renal tubule development GO:0061326
The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
1 P42225 (/ISO)
Renal tubule development GO:0061326
The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
1 P42225 (/ISS)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P40763 (/IDA)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P40763 (/IMP)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P42227 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P42225 (/IMP)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P42228 (/IDA)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P52631 (/IDA)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
1 O13133 (/IDA)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P52631 (/IDA)
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
1 P42227 (/IMP)
Regulation of mitochondrial fission GO:0090140
Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
1 P52630 (/IMP)
Regulation of mitochondrial fission GO:0090140
Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
1 Q9WVL2 (/ISO)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
1 P42227 (/IMP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P52631 (/IMP)
Positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728
Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.
1 P52631 (/IMP)
Positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter.
1 P40763 (/IDA)
Positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter.
1 P42227 (/IMP)
Positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter.
1 P42227 (/ISO)
Positive regulation of metalloendopeptidase activity GO:1904685
Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity.
1 P40763 (/IGI)
Positive regulation of metalloendopeptidase activity GO:1904685
Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity.
1 P42227 (/ISO)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
1 P40763 (/IDA)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
1 P42227 (/ISO)
Negative regulation of stem cell differentiation GO:2000737
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
1 P42227 (/IMP)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
1 P52631 (/IMP)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
1 P42227 (/IGI)

There are 32 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
24 A0A060VR90 (/ISS) A0A060VXY4 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS)
(14 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
24 A0A060VR90 (/ISS) A0A060VXY4 (/ISS) B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) E2RLW2 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS)
(14 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
17 A7LH49 (/IDA) B0JYL6 (/IDA) B5X3E8 (/IDA) B9UYM8 (/IDA) C0PUF7 (/IDA) C7EY83 (/IDA) F1M9D6 (/IDA) P40763 (/IDA) P42224 (/IDA) P42225 (/IDA)
(7 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
16 A0A0D9RIE1 (/IDA) A7LH49 (/IDA) B5X3E8 (/IDA) B9UYM8 (/IDA) C0PUF7 (/IDA) C7EY83 (/IDA) F1M9D6 (/IDA) P40763 (/IDA) P42224 (/IDA) P42225 (/IDA)
(6 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
14 B0JYL6 (/ISS) C8BKE1 (/ISS) C9K6U7 (/ISS) D2H881 (/ISS) F6WE02 (/ISS) F6ZBH0 (/ISS) F7I183 (/ISS) G1R4R1 (/ISS) G1SHL8 (/ISS) G3SFV1 (/ISS)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 B4DLC8 (/IDA) G8JLH9 (/IDA) J3KPM9 (/IDA) P40763 (/IDA) P42224 (/IDA) P52630 (/IDA) R9QE65 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P40763 (/TAS) P42224 (/TAS) P42225 (/TAS) P42227 (/TAS) P52630 (/TAS) P52631 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P40763 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q6DV79 (/ISS) Q9PVX8 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 G8JLH9 (/IDA) J3KPM9 (/IDA) P40763 (/IDA) P42224 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P40763 (/TAS) P42224 (/TAS) P42227 (/TAS) P52630 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 B4DLC8 (/IDA) P42227 (/IDA) P52630 (/IDA) R9QE65 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P42225 (/ISO) P42227 (/ISO) Q9WVL2 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
3 E2RLW2 (/ISS) P42224 (/ISS) P42225 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 E2RLW2 (/ISS) P42224 (/ISS) P42225 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
2 P40763 (/IDA) P42224 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
2 P42225 (/ISO) P42227 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P42225 (/ISO) P42227 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P42225 (/ISO) P42227 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 J3KPM9 (/IDA) P42224 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P42225 (/ISO) P42227 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 F1M9D6 (/IDA) Q66HB2 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P42225 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P40763 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P52631 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P52631 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9WVL2 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P42224 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P42225 (/ISO)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.
1 P40763 (/IC)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.
1 P40763 (/IMP)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.
1 P42227 (/ISO)