The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23148: Aspartic protease pep1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
19 G8B6X1 (/IDA) G8B6Y8 (/IDA) O60020 (/IDA) P0CY27 (/IDA) P0CY29 (/IDA) P0DJ06 (/IDA) P12630 (/IDA) P32329 (/IDA) P43094 (/IDA) P53379 (/IDA)
(9 more)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
3 P12630 (/IMP) P43094 (/IMP) Q5AC08 (/IMP)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
2 P40583 (/ISS) Q12303 (/ISS)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 P41748 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P0DJ06 (/IDA)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
14 A2R3L3 (/IDA) G8B6X1 (/IDA) G8B6Y8 (/IDA) O60020 (/IDA) P0CY27 (/IDA) P0CY29 (/IDA) P0DJ06 (/IDA) P43094 (/IDA) Q59SU1 (/IDA) Q59VH7 (/IDA)
(4 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
6 P0CY27 (/IMP) P0CY29 (/IMP) P0DJ06 (/IMP) P43094 (/IMP) Q59VH7 (/IMP) Q5AC08 (/IMP)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
5 P32329 (/IGI) P40583 (/IGI) P53379 (/IGI) Q12303 (/IGI) Q59SU1 (/IGI)
Adhesion of symbiont to host GO:0044406
The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.
5 P43094 (/IGI) Q59SU1 (/IGI) Q5A651 (/IGI) Q5A8N2 (/IGI) Q5AC08 (/IGI)
Adhesion of symbiont to host GO:0044406
The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.
5 P0CY27 (/IMP) P0CY29 (/IMP) P0DJ06 (/IMP) Q59SU1 (/IMP) Q5A651 (/IMP)
Signal peptide processing GO:0006465
The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.
4 P0CY27 (/IDA) P0CY29 (/IDA) P0DJ06 (/IDA) Q5AC08 (/IDA)
Protein metabolic process GO:0019538
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
4 P0CY27 (/IDA) P0CY29 (/IDA) P0DJ06 (/IDA) Q5AC08 (/IDA)
Induction by symbiont of defense-related host calcium ion flux GO:0052391
The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
4 P0CY27 (/IDA) P0CY29 (/IDA) P0DJ06 (/IDA) Q5AC08 (/IDA)
Nitrogen compound metabolic process GO:0006807
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
3 P43094 (/IGI) Q5A8N2 (/IGI) Q5AC08 (/IGI)
Nitrogen compound metabolic process GO:0006807
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
3 P0CY27 (/IMP) P0CY29 (/IMP) P0DJ06 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
3 P43094 (/IGI) Q5A8N2 (/IGI) Q5AC08 (/IGI)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
3 P43094 (/IGI) Q5A8N2 (/IGI) Q5AC08 (/IGI)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
3 P0CY27 (/IMP) P0CY29 (/IMP) P0DJ06 (/IMP)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
3 Q59SU1 (/IMP) Q5A651 (/IMP) Q6FJR5 (/IMP)
Cellular nitrogen compound catabolic process GO:0044270
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
3 P43094 (/IGI) Q5A8N2 (/IGI) Q5AC08 (/IGI)
Induction by symbiont of host defense response GO:0044416
The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
3 P0CY27 (/IDA) P0DJ06 (/IDA) Q5AC08 (/IDA)
Signal transduction involved in filamentous growth GO:0001402
Relaying of environmental signals promoting filamentous growth.
2 P32329 (/IMP) P53379 (/IMP)
Activation of immune response GO:0002253
Any process that initiates an immune response.
2 Q5A8N2 (/IMP) Q5AC08 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 P41748 (/IMP) P53379 (/IMP)
Single-species biofilm formation GO:0044010
A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
2 P43094 (/IMP) Q5AC08 (/IMP)
Adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion GO:0000754
In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
1 P12630 (/IDA)
Adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion GO:0000754
In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.
1 P12630 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 G4NI47 (/RCA)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 Q01972 (/IDA)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 P0DJ06 (/IDA)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 P32329 (/IGI)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 P32329 (/IMP)
Evasion or tolerance of host immune response GO:0020012
Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q5A8N2 (/IEP)
Evasion or tolerance of host immune response GO:0020012
Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q5A8N2 (/IGI)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 P0DJ06 (/IDA)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
1 Q59SU1 (/ISS)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
1 P12630 (/IDA)
Cellular protein catabolic process GO:0044257
The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
1 P0DJ06 (/IMP)
Modulation by symbiont of host cell-mediated immune response GO:0052155
Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q59SU1 (/IMP)
Induction by symbiont of host immune response GO:0052559
Any process in which an organism activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P0CY27 (/IDA)
Response to ammonium ion GO:0060359
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.
1 Q01972 (/IDA)
Peptide mating pheromone maturation involved in conjugation with cellular fusion GO:0071432
The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion.
1 P32329 (/IGI)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
16 G8B6X1 (/IDA) G8B6Y8 (/IDA) O60020 (/IDA) P0CY27 (/IDA) P0CY29 (/IDA) P0DJ06 (/IDA) P12630 (/IDA) P41748 (/IDA) P43094 (/IDA) P78735 (/IDA)
(6 more)
Fungal-type cell wall GO:0009277
A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.
6 G8B6X1 (/IDA) P12630 (/IDA) P40583 (/IDA) P53379 (/IDA) Q59SU1 (/IDA) Q5A651 (/IDA)
Anchored component of plasma membrane GO:0046658
The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
4 P32329 (/IDA) Q12303 (/IDA) Q59SU1 (/IDA) Q5A651 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
3 P43094 (/IDA) Q5A8N2 (/IDA) Q5AC08 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q59SU1 (/IDA) Q5A651 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q59SU1 (/IMP) Q5A651 (/IMP)
Biofilm matrix GO:0097311
A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria.
2 P43094 (/IDA) Q5AC08 (/IDA)
Anchored component of membrane GO:0031225
The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
1 Q59SU1 (/IDA)
Anchored component of plasma membrane GO:0046658
The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
1 Q12303 (/IPI)