The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18983: Calcium channel voltage-dependent beta2 subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 A0A0R4INX9 (/IPI) D4A055 (/IPI) E7F185 (/IPI) F1R605 (/IPI) O00305 (/IPI) P54283 (/IPI) P54288 (/IPI) Q08289 (/IPI) Q2Q551 (/IPI) Q2Q552 (/IPI)
(5 more)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
9 A0A0R4INX9 (/IMP) D4A055 (/IMP) E7F185 (/IMP) F1R605 (/IMP) Q2Q551 (/IMP) Q2Q552 (/IMP) Q6DG31 (/IMP) Q8R0S4 (/IMP) Q8R3Z5 (/IMP)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
8 A0A0R4IEL6 (/IDA) B0F0C6 (/IDA) B0F0C7 (/IDA) B0F0C8 (/IDA) B0F0D1 (/IDA) Q08289 (/IDA) Q8R3Z5 (/IDA) T2B3N4 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
3 D4A055 (/IDA) P54283 (/IDA) Q8VGC3 (/IDA)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
2 Q02641 (/TAS) Q8VGC3 (/TAS)
High voltage-gated calcium channel activity GO:0008331
Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
2 Q8CC27 (/TAS) Q8R0S4 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P54283 (/IPI) Q8VGC3 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 P54283 (/IPI) Q8VGC3 (/IPI)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
2 Q8CC27 (/IDA) Q8VGC3 (/IDA)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
2 P54283 (/IPI) Q8VGC3 (/IPI)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 Q8CC27 (/ISO)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
1 Q8VGC3 (/IDA)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q9MZL7 (/IDA)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q08289 (/NAS)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 O00305 (/TAS)
High voltage-gated calcium channel activity GO:0008331
Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
1 Q8R3Z5 (/IGI)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q08289 (/ISS)

There are 53 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
11 A0A0R4IFE8 (/IMP) A0A0R4IK22 (/IMP) A0A0R4IM34 (/IMP) A0A0R4IMP5 (/IMP) A0A0R4IQY8 (/IMP) A0A0R4IWG7 (/IMP) A0A0R4IXU9 (/IMP) A2SZ54 (/IMP) B2XY76 (/IMP) B2XY78 (/IMP)
(1 more)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
9 A0A0R4IEL6 (/IMP) A8WHZ4 (/IMP) A8WHZ5 (/IMP) B0F0C6 (/IMP) B0F0C7 (/IMP) B0F0C8 (/IMP) B0F0D0 (/IMP) B0F0D1 (/IMP) T2B3N4 (/IMP)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
6 A0A0R4INX9 (/IMP) E7F185 (/IMP) F1R605 (/IMP) Q2Q551 (/IMP) Q2Q552 (/IMP) Q6DG31 (/IMP)
Voltage-gated calcium channel complex assembly GO:0070978
Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex.
6 A0A0R4INX9 (/IMP) E7F185 (/IMP) F1R605 (/IMP) Q2Q551 (/IMP) Q2Q552 (/IMP) Q6DG31 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 D4A055 (/IMP) Q8R0S4 (/IMP) Q8R3Z5 (/IMP)
Cardiac conduction GO:0061337
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
3 O00305 (/TAS) Q02641 (/TAS) Q08289 (/TAS)
Transport GO:0006810
The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.
2 O00305 (/TAS) Q02641 (/TAS)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
2 Q8CC27 (/ISS) Q8VGC3 (/ISS)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
2 Q8CC27 (/ISS) Q8VGC3 (/ISS)
Establishment of protein localization to plasma membrane GO:0090002
The directed movement of a protein to a specific location in the plasma membrane.
2 Q08289 (/ISS) Q8CC27 (/ISS)
Membrane depolarization during atrial cardiac muscle cell action potential GO:0098912
The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
2 Q8CC27 (/ISS) Q8VGC3 (/ISS)
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
2 Q08289 (/ISS) Q8CC27 (/ISS)
Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1904879
Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel.
2 Q08289 (/ISS) Q8CC27 (/ISS)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q8R3Z5 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8VGC3 (/TAS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q8R0S4 (/IMP)
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
1 Q8R0S4 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 Q8CC27 (/IMP)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
1 Q8R0S4 (/IMP)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
1 Q08289 (/TAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 Q8CC27 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
1 Q8R0S4 (/IMP)
Gamma-aminobutyric acid secretion GO:0014051
The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues.
1 Q8R0S4 (/IMP)
Neuronal action potential propagation GO:0019227
The propagation of an action potential along an axon, away from the soma.
1 Q8R0S4 (/IMP)
Synaptic transmission, glutamatergic GO:0035249
The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 Q8R0S4 (/IMP)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
1 O01661 (/IMP)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
1 Q8R0S4 (/IMP)
CAMP metabolic process GO:0046058
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 Q8R0S4 (/IMP)
Spleen development GO:0048536
The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.
1 Q8R0S4 (/IMP)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
1 Q8R0S4 (/IMP)
Peyer's patch development GO:0048541
The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.
1 Q8R0S4 (/IMP)
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
1 Q8R0S4 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 Q8R0S4 (/IMP)
Neurological system process GO:0050877
A organ system process carried out by any of the organs or tissues of neurological system.
1 Q8R0S4 (/IMP)
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
1 Q8R0S4 (/IMP)
Membrane depolarization GO:0051899
The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
1 O00305 (/TAS)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O01661 (/IMP)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q08289 (/IDA)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8CC27 (/ISO)
Striated muscle contraction involved in embryonic body morphogenesis GO:0061199
The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology.
1 O01661 (/IMP)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
1 Q08289 (/IDA)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
1 Q8CC27 (/ISO)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q08289 (/IMP)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q8CC27 (/ISO)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
1 Q08289 (/IMP)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
1 Q8CC27 (/ISO)
Establishment of protein localization to plasma membrane GO:0090002
The directed movement of a protein to a specific location in the plasma membrane.
1 Q8VGC3 (/IDA)
Membrane depolarization during atrial cardiac muscle cell action potential GO:0098912
The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q08289 (/IMP)
Membrane depolarization during atrial cardiac muscle cell action potential GO:0098912
The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q8CC27 (/ISO)
Regulation of voltage-gated calcium channel activity GO:1901385
Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.
1 O00305 (/IMP)
Regulation of voltage-gated calcium channel activity GO:1901385
Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.
1 Q8R0S4 (/ISO)
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
1 Q8VGC3 (/IDA)
Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1904879
Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel.
1 Q8VGC3 (/IDA)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
13 A0A0R4INX9 (/IDA) E7F185 (/IDA) F1R605 (/IDA) O00305 (/IDA) P54283 (/IDA) Q08289 (/IDA) Q2Q551 (/IDA) Q2Q552 (/IDA) Q6DG31 (/IDA) Q8CC27 (/IDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 O00305 (/TAS) Q02641 (/TAS) Q08289 (/TAS) Q8CC27 (/TAS) Q8R0S4 (/TAS) Q8R3Z5 (/TAS)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
6 A0A0R4INX9 (/IC) E7F185 (/IC) F1R605 (/IC) Q2Q551 (/IC) Q2Q552 (/IC) Q6DG31 (/IC)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 A0A0R4INX9 (/ISS) E7F185 (/ISS) F1R605 (/ISS) Q2Q551 (/ISS) Q2Q552 (/ISS) Q6DG31 (/ISS)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
2 Q8CC27 (/ISO) Q8R0S4 (/ISO)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
2 P19517 (/IDA) Q8R3Z5 (/IDA)
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
2 P19517 (/IDA) Q08289 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O00305 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O00305 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8R0S4 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q08289 (/NAS)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
1 Q8R0S4 (/IMP)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
1 Q02641 (/TAS)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 O00305 (/TAS)
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
1 Q8R3Z5 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 O00305 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q8R0S4 (/ISO)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
1 O01661 (/IDA)
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
1 Q8CC27 (/ISO)