The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SET domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5086: Probable histone-lysine N-methyltransferase Mes-4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 43 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O96028 (/IPI) Q2LAE1 (/IPI) Q8MT36 (/IPI) Q9BYW2 (/IPI) Q9BZ95 (/IPI)
Histone methyltransferase activity (H3-K36 specific) GO:0046975
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
5 O14026 (/IDA) O88491 (/IDA) P46995 (/IDA) Q96L73 (/IDA) Q9BYW2 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
4 O96028 (/TAS) Q96L73 (/TAS) Q9BYW2 (/TAS) Q9BZ95 (/TAS)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
3 Q8BVE8 (/IDA) Q9BYW2 (/IDA) Q9BZ95 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 O88491 (/IDA) Q8BVE8 (/IDA)
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
2 O88491 (/IDA) Q96L73 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2 E9Q5F9 (/ISO) Q6P2L6 (/ISO)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2 E9Q5F9 (/ISS) Q9VYD1 (/ISS)
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
2 P46995 (/ISS) Q8MT36 (/ISS)
Histone methyltransferase activity (H3-K4 specific) GO:0042800
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
2 Q2LAE1 (/IDA) Q6P2L6 (/IDA)
Histone methyltransferase activity (H3-K36 specific) GO:0046975
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
2 P46995 (/IMP) Q9VYD1 (/IMP)
Histone methyltransferase activity (H3-K36 specific) GO:0046975
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
2 E9Q5F9 (/ISO) O88491 (/ISO)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
1 Q96L73 (/IDA)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.
1 O88491 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q96L73 (/ISS)
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
1 O88491 (/ISO)
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
1 O88491 (/ISS)
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
1 O88491 (/IDA)
Transcription corepressor activity GO:0003714
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
1 Q96L73 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q96L73 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 O88491 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 O88491 (/ISS)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q9BYW2 (/IMP)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 O88491 (/IPI)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 Q96L73 (/ISS)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
1 Q8MT36 (/IDA)
Histone methyltransferase activity GO:0042054
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
1 O88491 (/IDA)
Histone methyltransferase activity (H4-K20 specific) GO:0042799
Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein.
1 O88491 (/IDA)
Histone methyltransferase activity (H4-K20 specific) GO:0042799
Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein.
1 Q96L73 (/ISS)
Histone methyltransferase activity (H4-K20 specific) GO:0042799
Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein.
1 O96028 (/TAS)
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
1 O88491 (/IPI)
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
1 Q96L73 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q8BVE8 (/IDA)
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
1 O88491 (/IPI)
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
1 Q96L73 (/ISS)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 O88491 (/IPI)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 Q96L73 (/ISS)
Histone methyltransferase activity (H3-K36 specific) GO:0046975
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
1 Q96L73 (/ISS)
Histone methyltransferase activity (H3-K27 specific) GO:0046976
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein.
1 Q6P2L6 (/IDA)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q96L73 (/IDA)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 O88491 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 O88491 (/ISS)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
1 Q9VYD1 (/IPI)

There are 98 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone H3-K36 methylation GO:0010452
The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.
6 B7ZVT1 (/IMP) B8JIA4 (/IMP) E9Q5F9 (/IMP) Q1LY48 (/IMP) Q561Q3 (/IMP) Q9VYD1 (/IMP)
Embryonic skeletal system development GO:0048706
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
4 B7ZVT1 (/IMP) B8JIA4 (/IMP) Q1LY48 (/IMP) Q561Q3 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
4 B7ZVT1 (/IMP) B8JIA4 (/IMP) Q1LY48 (/IMP) Q561Q3 (/IMP)
Histone H3-K36 methylation GO:0010452
The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.
3 O14026 (/IDA) Q2LAE1 (/IDA) Q8BVE8 (/IDA)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
3 O88491 (/IDA) P46995 (/IDA) Q9BZ95 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P46995 (/IMP) Q8BVE8 (/IMP)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
2 Q96L73 (/ISS) Q9VYD1 (/ISS)
Histone H3-K36 trimethylation GO:0097198
The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone.
2 E9Q5F9 (/IMP) Q9BYW2 (/IMP)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O88491 (/IDA)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8BVE8 (/IGI)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q96L73 (/ISS)
Regulation of histone H3-K36 methylation GO:0000414
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
1 Q96L73 (/IMP)
Regulation of histone H3-K36 methylation GO:0000414
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
1 O88491 (/ISO)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 E9Q5F9 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 E9Q5F9 (/IMP)
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
1 O88491 (/IMP)
Morphogenesis of a branching structure GO:0001763
The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
1 E9Q5F9 (/IMP)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
1 E9Q5F9 (/IMP)
Instar larval development GO:0002168
The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.
1 Q9VYD1 (/IMP)
Membranous septum morphogenesis GO:0003149
The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
1 Q8BVE8 (/IMP)
Atrial septum primum morphogenesis GO:0003289
The process in which anatomical structure of an atrial septum primum is generated and organized.
1 Q8BVE8 (/IMP)
Atrial septum secundum morphogenesis GO:0003290
The process in which anatomical structure of an atrial septum secundum is generated and organized.
1 Q8BVE8 (/IMP)
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
1 Q9BYW2 (/IMP)
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
1 E9Q5F9 (/ISO)
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
1 E9Q5F9 (/ISS)
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
1 O96028 (/TAS)
DNA-templated transcription, termination GO:0006353
The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.
1 P46995 (/IMP)
DNA-templated transcription, elongation GO:0006354
The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
1 P46995 (/IDA)
DNA-templated transcription, elongation GO:0006354
The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
1 P46995 (/IPI)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P46995 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 O88491 (/TAS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O14026 (/IC)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
1 O14026 (/IGI)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
1 Q9BYW2 (/IMP)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
1 E9Q5F9 (/ISO)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
1 E9Q5F9 (/ISS)
Embryo sac development GO:0009553
The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.
1 Q2LAE1 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
1 Q2LAE1 (/IMP)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
1 O96028 (/TAS)
Negative regulation of flower development GO:0009910
Any process that stops, prevents, or reduces the frequency, rate or extent of flower development.
1 Q2LAE1 (/IMP)
Secondary shoot formation GO:0010223
The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs.
1 Q2LAE1 (/IMP)
Regulation of plant-type hypersensitive response GO:0010363
Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response.
1 Q2LAE1 (/IMP)
Histone H3-K36 methylation GO:0010452
The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.
1 Q8MT36 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 E9Q5F9 (/IMP)
Regulation of mRNA export from nucleus GO:0010793
Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm.
1 Q9BYW2 (/IMP)
Regulation of mRNA export from nucleus GO:0010793
Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm.
1 E9Q5F9 (/ISO)
Carotenoid metabolic process GO:0016116
The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.
1 Q2LAE1 (/IMP)
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
1 Q8MT36 (/ISS)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 P46995 (/IMP)
Histone methylation GO:0016571
The modification of histones by addition of methyl groups.
1 Q6P2L6 (/ISO)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
1 P46995 (/IMP)
Peptidyl-lysine trimethylation GO:0018023
The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.
1 E9Q5F9 (/IMP)
Germ-line sex determination GO:0018992
The determination of sex and sexual phenotype in an organism's germ line.
1 Q8MT36 (/ISS)
Regulation of DNA-dependent DNA replication initiation GO:0030174
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
1 P46995 (/IMP)
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
1 P46995 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 E9Q5F9 (/IMP)
Positive regulation of histone methylation GO:0031062
Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.
1 Q2LAE1 (/IDA)
Regulation of peptidyl-serine phosphorylation GO:0033135
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 Q96L73 (/IMP)
Regulation of peptidyl-serine phosphorylation GO:0033135
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 O88491 (/ISO)
Nucleosome organization GO:0034728
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.
1 Q9BYW2 (/IMP)
Nucleosome organization GO:0034728
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.
1 E9Q5F9 (/ISO)
Nucleosome organization GO:0034728
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.
1 E9Q5F9 (/ISS)
Histone H4-K20 methylation GO:0034770
The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone.
1 Q8BVE8 (/IDA)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
1 P46995 (/IGI)
Ecdysone receptor-mediated signaling pathway GO:0035076
The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex.
1 Q9VYD1 (/IGI)
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
1 Q9VYD1 (/IMP)
Cell migration involved in vasculogenesis GO:0035441
The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.
1 E9Q5F9 (/IMP)
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
1 Q2LAE1 (/IMP)
Regulation of programmed cell death GO:0043067
Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
1 Q2LAE1 (/IGI)
Negative regulation of reciprocal meiotic recombination GO:0045128
Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
1 P46995 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q6P2L6 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q96L73 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 O88491 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 O88491 (/ISS)
Positive regulation of isotype switching to IgA isotypes GO:0048298
Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes.
1 Q8BVE8 (/IMP)
Mesoderm morphogenesis GO:0048332
The process in which the anatomical structures of the mesoderm are generated and organized.
1 E9Q5F9 (/IMP)
Plant ovule development GO:0048481
The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed.
1 Q2LAE1 (/IMP)
Embryonic organ development GO:0048568
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 E9Q5F9 (/IMP)
Anther development GO:0048653
The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure.
1 Q2LAE1 (/IMP)
Embryonic cranial skeleton morphogenesis GO:0048701
The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.
1 E9Q5F9 (/IMP)
Stem cell development GO:0048864
The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.
1 E9Q5F9 (/IMP)
Pericardium development GO:0060039
The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.
1 E9Q5F9 (/IMP)
Negative regulation of antisense RNA transcription GO:0060195
Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA.
1 P46995 (/IMP)
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
1 Q8BVE8 (/IMP)
Embryonic placenta morphogenesis GO:0060669
The process in which the embryonic placenta is generated and organized.
1 E9Q5F9 (/IMP)
Coronary vasculature morphogenesis GO:0060977
The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.
1 E9Q5F9 (/IMP)
Regulation of establishment of protein localization GO:0070201
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
1 Q8BVE8 (/IMP)
Negative regulation of histone H3-K14 acetylation GO:0071441
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone.
1 P46995 (/IMP)
Histone H3-K36 trimethylation GO:0097198
The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone.
1 Q9BYW2 (/IDA)
Histone H3-K36 trimethylation GO:0097198
The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone.
1 E9Q5F9 (/ISO)
Histone H3-K36 trimethylation GO:0097198
The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone.
1 E9Q5F9 (/ISS)
Histone H3-K36 dimethylation GO:0097676
The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone.
1 Q9BYW2 (/IDA)
Histone H3-K36 dimethylation GO:0097676
The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone.
1 E9Q5F9 (/ISO)
Regulation of histone exchange GO:1900049
Any process that modulates the frequency, rate or extent of histone exchange.
1 P46995 (/IMP)
Regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903025
Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
1 Q96L73 (/IMP)
Regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903025
Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
1 O88491 (/ISO)
Negative regulation of histone H3-K9 acetylation GO:2000616
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation.
1 P46995 (/IMP)
Regulation of double-strand break repair via nonhomologous end joining GO:2001032
Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
1 Q8BVE8 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 E9Q5F9 (/IDA) O14026 (/IDA) O88491 (/IDA) O96028 (/IDA) P46995 (/IDA) Q2LAE1 (/IDA) Q8BVE8 (/IDA) Q9VYD1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 O96028 (/TAS) Q96L73 (/TAS) Q9BYW2 (/TAS) Q9BZ95 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O88491 (/IC) Q9BZ95 (/IC)
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
1 Q8MT36 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 O14026 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P46995 (/IPI)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BVE8 (/ISO)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
1 Q8MT36 (/IDA)
Pericentric heterochromatin GO:0005721
Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
1 Q8MT36 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P46995 (/IDA)
DNA-directed RNA polymerase II, holoenzyme GO:0016591
A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters.
1 O14026 (/IDA)
Histone methyltransferase complex GO:0035097
A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
1 O88491 (/IC)