The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Hexapeptide repeat proteins

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 82581: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-ace...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. [EC:]
Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.
  • Involved in the biosynthesis of lysine in bacteria, cyanobacteria and higher plants.
  • Earlier erroneously called 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase.
5454 A0A010PNS7 A0A010PNS7 A0A010S1U8 A0A010S1U8 A0A011SP01 A0A011SP01 A0A014LGD4 A0A014LGD4 A0A021VRZ3 A0A021VRZ3
(5444 more...)
Tetrahydrodipicolinate N-acetyltransferase. [EC:]
Acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O = CoA + L-2-acetamido-6-oxoheptanedioate.
    4400 A0A011Q5F1 A0A011Q5F1 A0A022N953 A0A022N953 A0A023CQR7 A0A023CQR7 A0A023D0Z1 A0A023D0Z1 A0A023DCR5 A0A023DCR5
    (4390 more...)
    Proline dehydrogenase. [EC:]
    L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
    • The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor.
    • In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC
    • Both activities are carried out by the same enzyme in enterobacteria.
    • Formerly EC
    16 A0A0H3M5H2 A0A0H3M5H2 A0A1A9E5I3 A0A1A9E5I3 A0A1L7MG05 A0A1L7MG05 A5U1P9 A5U1P9 F8M5Z8 F8M5Z8
    (6 more...)
    Serine O-acetyltransferase. [EC:]
    Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
      2 A0A0T8PYU5 A0A0T8PYU5
      Aspartate-semialdehyde dehydrogenase. [EC:]
      L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH.
        2 R2PWT6 R2PWT6