View in Gene3D

CATH Superfamily 2.10.70.10

Complement Module, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Complement Module, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 17214: CUB and sushi domain-containing protein 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Limulus clotting factor C. [EC: 3.4.21.84]
Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro- Arg-|-Xaa- bonds in synthetic substrates.
  • From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus.
  • Factor C is activated by Gram-negative bacterial lipopolysaccharides and chymotrypsin.
  • Inhibited by antithrombin III.
  • Belongs to peptidase family S1.
 4 B7QCS5 B7QCS5 B7QJR3 B7QJR3
Mannan-binding lectin-associated serine protease-2. [EC: 3.4.21.104]
Selective cleavage after Arg-223 in complement component C2 (-Ser- Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
  • Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement.
  • Displays C1s-like esterolytic activity (cf. EC 3.4.21.42).
  • It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42.
  • Belongs to peptidase family S1A.
 2 B7QCS5 B7QCS5
CATH-Gene3D is a Global Biodata Core Resource Learn more...