The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Laminin
".
FunFam 44030: Fibrillin-2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P35555 (/IPI) P35556 (/IPI) Q61554 (/IPI) Q61555 (/IPI) |
|
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Extracellular matrix constituent conferring elasticity GO:0030023
A component of the extracellular matrix that enables the matrix to recoil after transient stretching.
|
2 | P35555 (/IC) P35556 (/IC) |
|
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
1 | P35555 (/IPI) |
|
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
1 | Q61554 (/ISO) |
|
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
|
1 | P35555 (/IDA) |
|
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | P35555 (/IDA) |
|
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | G3V9M6 (/IMP) |
|
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | Q61554 (/ISO) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | P35555 (/IDA) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q61554 (/ISO) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q61555 (/TAS) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | P35555 (/IDA) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | Q61554 (/ISO) |
|
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P35555 (/IPI) |
|
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q61554 (/ISO) |
There are 51 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Protein kinase A signaling GO:0010737
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Activation of protein kinase A activity GO:0034199
Any process that initiates the activity of the inactive enzyme protein kinase A.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
|
2 | P35555 (/TAS) P35556 (/TAS) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
2 | P35555 (/TAS) P35556 (/TAS) |
|
Sequestering of TGFbeta in extracellular matrix GO:0035583
Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.
|
2 | Q61554 (/IMP) Q61555 (/IMP) |
|
Sequestering of TGFbeta in extracellular matrix GO:0035583
Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.
|
2 | P35555 (/ISS) P35556 (/ISS) |
|
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
|
2 | P35555 (/IEP) P35556 (/IEP) |
|
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
|
2 | P35555 (/IDA) Q61554 (/IDA) |
|
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
|
2 | P35555 (/IEP) P35556 (/IEP) |
|
Negative regulation of osteoclast development GO:2001205
Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.
|
2 | P35555 (/IDA) Q61554 (/IDA) |
|
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
1 | P35555 (/IMP) |
|
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
1 | Q61554 (/ISO) |
|
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
1 | B6CS38 (/IMP) |
|
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
|
1 | G3V9M6 (/IMP) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | G3V9M6 (/IEP) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | G3V9M6 (/IMP) |
|
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | B6CS38 (/IGI) |
|
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | B6CS38 (/IMP) |
|
Endocardium morphogenesis GO:0003160
The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
|
1 | B6CS38 (/IGI) |
|
Regulation of cell proliferation involved in heart valve morphogenesis GO:0003250
Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
|
1 | B6CS38 (/IGI) |
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
1 | P35555 (/IDA) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | B6CS38 (/IGI) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | P35555 (/IMP) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
1 | Q61554 (/ISO) |
|
Protein kinase A signaling GO:0010737
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
|
1 | P35555 (/IDA) |
|
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
|
1 | Q61555 (/IMP) |
|
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
|
1 | Q61555 (/IMP) |
|
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
|
1 | P35556 (/ISS) |
|
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
|
1 | P35555 (/IDA) |
|
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
|
1 | Q61554 (/ISO) |
|
Activation of protein kinase A activity GO:0034199
Any process that initiates the activity of the inactive enzyme protein kinase A.
|
1 | P35555 (/IDA) |
|
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
|
1 | Q61555 (/IMP) |
|
Sequestering of BMP in extracellular matrix GO:0035582
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
|
1 | Q61554 (/IMP) |
|
Sequestering of BMP in extracellular matrix GO:0035582
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
|
1 | P35555 (/ISS) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
1 | P35555 (/IDA) |
|
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
1 | P35555 (/TAS) |
|
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
1 | P35555 (/TAS) |
|
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
1 | Q61555 (/IMP) |
|
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
1 | P35556 (/ISS) |
|
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
|
1 | Q61554 (/ISO) |
|
Post-embryonic eye morphogenesis GO:0048050
The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight.
|
1 | P35555 (/IEP) |
|
Notochord morphogenesis GO:0048570
The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
|
1 | B6CS38 (/IGI) |
|
Notochord morphogenesis GO:0048570
The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
|
1 | B6CS38 (/IMP) |
|
Bone trabecula formation GO:0060346
The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.
|
1 | Q61555 (/IMP) |
|
Bone trabecula formation GO:0060346
The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.
|
1 | P35556 (/ISS) |
|
Endocardial cell development GO:0060958
The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart.
|
1 | B6CS38 (/IGI) |
|
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
1 | G3V9M6 (/IEP) |
|
Cellular response to insulin-like growth factor stimulus GO:1990314
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
|
1 | G3V9M6 (/IEP) |
|
Negative regulation of osteoclast development GO:2001205
Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.
|
1 | Q61554 (/ISO) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
20 |
A0A087R0H9 (/ISS)
A0A091J1G3 (/ISS)
A0A091UR82 (/ISS)
A0A091W8G5 (/ISS)
A0A093I4R3 (/ISS)
A0A093N9R7 (/ISS)
A0A096MRY0 (/ISS)
A0A099ZS71 (/ISS)
A0A0A0ASV9 (/ISS)
E2RS46 (/ISS)
(10 more) |
|
Microfibril GO:0001527
Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
|
5 | P35555 (/IDA) P35556 (/IDA) P98133 (/IDA) Q61554 (/IDA) Q61555 (/IDA) |
|
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support for cells or tissues.
|
5 | G3V9M6 (/IDA) P35555 (/IDA) P35556 (/IDA) Q61554 (/IDA) Q61555 (/IDA) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
4 | P35555 (/TAS) P35556 (/TAS) P98133 (/TAS) Q61555 (/TAS) |
|
Microfibril GO:0001527
Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
|
3 | P35556 (/TAS) Q61554 (/TAS) Q61555 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | G3V9M6 (/IDA) P35555 (/IDA) Q61555 (/IDA) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | P98133 (/ISS) Q61554 (/ISS) Q9TV36 (/ISS) |
|
Microfibril GO:0001527
Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.
|
2 | Q61554 (/ISO) Q61555 (/ISO) |
|
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
|
2 | P35555 (/IDA) Q61554 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P35555 (/IDA) Q61554 (/IDA) |
|
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support for cells or tissues.
|
2 | Q61554 (/ISO) Q61555 (/ISO) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q61554 (/ISO) |
|
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
|
1 | Q61554 (/ISO) |
|
Basement membrane GO:0005604
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
1 | P35555 (/IDA) |
|
Basement membrane GO:0005604
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
1 | Q61554 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q61554 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | E1C3A6 (/IDA) |
|
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
1 | P35555 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P35555 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q61554 (/ISO) |