# STOCKHOLM 1.0
#=GF ID 1.25.10.10/FF/68569
#=GF DE E3 ubiquitin-protein ligase HUWE1
#=GF AC 1.25.10.10/FF/68569
#=GF TP FunFam
#=GF DR CATH: 4.2
#=GF DR DOPS: 38.120
#=GS A0A0S7H2E3/275-484  AC A0A0S7H2E3
#=GS A0A0S7H2E3/275-484  OS Poeciliopsis prolifica
#=GS A0A0S7H2E3/275-484  DE HUWE1
#=GS A0A0S7H2E3/275-484  DR GENE3D; 1b4514fc80f3d2b764e1d4a6ed2241f0/275-484; 
#=GS A0A0S7H2E3/275-484  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Poeciliopsis; Poeciliopsis prolifica; 
#=GS A0A1D5Q3Z2/257-476  AC A0A1D5Q3Z2
#=GS A0A1D5Q3Z2/257-476  OS Macaca mulatta
#=GS A0A1D5Q3Z2/257-476  DE Uncharacterized protein
#=GS A0A1D5Q3Z2/257-476  DR GENE3D; 1ed6e298038603973e468b4653cd5644/257-476; 
#=GS A0A1D5Q3Z2/257-476  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS A0A1D5QQ50/257-475  AC A0A1D5QQ50
#=GS A0A1D5QQ50/257-475  OS Macaca mulatta
#=GS A0A1D5QQ50/257-475  DE Uncharacterized protein
#=GS A0A1D5QQ50/257-475  DR GENE3D; 3b7ebae40415f3fdd263f81402fc4155/257-475; 
#=GS A0A1D5QQ50/257-475  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS A0A151NPY6/305-516  AC A0A151NPY6
#=GS A0A151NPY6/305-516  OS Alligator mississippiensis
#=GS A0A151NPY6/305-516  DE E3 ubiquitin-protein ligase HUWE1
#=GS A0A151NPY6/305-516  DR GENE3D; 4e4ae59b1df17b5c6598404db2790652/305-516; 
#=GS A0A151NPY6/305-516  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Crocodylia; Alligatoridae; Alligatorinae; Alligator; Alligator mississippiensis; 
#=GS Q5RJQ1/4-211        AC Q5RJQ1
#=GS Q5RJQ1/4-211        OS Rattus norvegicus
#=GS Q5RJQ1/4-211        DE LOC501546 protein
#=GS Q5RJQ1/4-211        DR GENE3D; 54c91684cff5fd731c007d419f6c1355/4-211; 
#=GS Q5RJQ1/4-211        DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; 
#=GS A0A0S7H630/44-255   AC A0A0S7H630
#=GS A0A0S7H630/44-255   OS Poeciliopsis prolifica
#=GS A0A0S7H630/44-255   DE HUWE1
#=GS A0A0S7H630/44-255   DR GENE3D; 68485a46cf120d5c342bfb5bf33881d6/44-255; 
#=GS A0A0S7H630/44-255   DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Poeciliopsis; Poeciliopsis prolifica; 
#=GS A0A1D5RHP8/186-407  AC A0A1D5RHP8
#=GS A0A1D5RHP8/186-407  OS Macaca mulatta
#=GS A0A1D5RHP8/186-407  DE Uncharacterized protein
#=GS A0A1D5RHP8/186-407  DR GENE3D; 7ed8903b5f402e848952f842db31a65e/186-407; 
#=GS A0A1D5RHP8/186-407  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS A0A060XZY6/276-487  AC A0A060XZY6
#=GS A0A060XZY6/276-487  OS Oncorhynchus mykiss
#=GS A0A060XZY6/276-487  DE Uncharacterized protein
#=GS A0A060XZY6/276-487  DR GENE3D; a287f8f67b8362c01d4059f78b01422c/276-487; 
#=GS A0A060XZY6/276-487  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus; Oncorhynchus mykiss; 
#=GS E9PSZ5/260-475      AC E9PSZ5
#=GS E9PSZ5/260-475      OS Rattus norvegicus
#=GS E9PSZ5/260-475      DE E3 ubiquitin-protein ligase HUWE1
#=GS E9PSZ5/260-475      DR GENE3D; b551cceb223e628185eedf48583be25a/260-475; 
#=GS E9PSZ5/260-475      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Rattus; Rattus norvegicus; 
#=GS S4RFL5/59-312       AC S4RFL5
#=GS S4RFL5/59-312       OS Petromyzon marinus
#=GS S4RFL5/59-312       DE Uncharacterized protein
#=GS S4RFL5/59-312       DR GENE3D; db5250939298eaa8f6b914f3d16304df/59-312; 
#=GS S4RFL5/59-312       DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Petromyzontiformes; Petromyzontidae; Petromyzon; Petromyzon marinus; 
#=GS H3BXZ7/241-448      AC H3BXZ7
#=GS H3BXZ7/241-448      OS Tetraodon nigroviridis
#=GS H3BXZ7/241-448      DE Uncharacterized protein
#=GS H3BXZ7/241-448      DR GENE3D; f61e5198063d0c6f7a901c2fb4c8bbbb/241-448; 
#=GS H3BXZ7/241-448      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Tetraodontiformes; Tetraodontoidei; Tetradontoidea; Tetraodontidae; Tetraodon; Tetraodon nigroviridis; 
#=GS C3YLJ3/273-481      AC C3YLJ3
#=GS C3YLJ3/273-481      OS Branchiostoma floridae
#=GS C3YLJ3/273-481      DE Putative uncharacterized protein
#=GS C3YLJ3/273-481      DR GENE3D; ff2b82417c4df20a247e22dfc61d5dd4/273-481; 
#=GS C3YLJ3/273-481      DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; 
#=GS H2YZN3/266-628      AC H2YZN3
#=GS H2YZN3/266-628      OS Ciona savignyi
#=GS H2YZN3/266-628      DE Uncharacterized protein
#=GS H2YZN3/266-628      DR GENE3D; ccbcb6cb0248956ba9e4d6a8c596fb5c/266-628; 
#=GS H2YZN3/266-628      DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona savignyi; 
#=GF TC 436.9 6.4E-135
#=GF SQ 13
A0A0S7H2E3/275-484          --------------------------------------------------QAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLVDIKAASLRTLTSIVHL---ERTPKLSNIIDCTGTASYHGFLPVLVRNCIQAMIDPSMEPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFICRLE----HEVDLSRKECPFVIKPKIQRPSA--------------------------------------------------------------------------------------------------------------------------------------------------
A0A1D5Q3Z2/257-476          --------------------------------LFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHL---ERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLE----HEVDLCRKECPFVIK----------------------------------------------------------------------------------------------------------------------------------------------------------
A0A1D5QQ50/257-475          --------------------------------LFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHL---ERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLE----HEVDLCRKECPFVI-----------------------------------------------------------------------------------------------------------------------------------------------------------
A0A151NPY6/305-516          -------------------------------------------SNHKKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMDIKAASLRTLTSIVHL---ERTPKLSSIIDCTGTASYHGFLPVLVRTCIQAMIDPSMEPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLE----HEVDLCRRECPFVIKPKI-------------------------------------------------------------------------------------------------------------------------------------------------------
Q5RJQ1/4-211                --------------------------------------------NHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHL---ERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLE----HEVDLCRKECPFVIK----------------------------------------------------------------------------------------------------------------------------------------------------------
A0A0S7H630/44-255           --------------------------------------------------QAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLVDIKAASLRTLTSIVHL---ERTPKLSNIIDCTGTASYHGFLPVLVRNCIQAMIDPSMEPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFICRLE----HEVDLSRKECPFVIKPKIQRPSATV------------------------------------------------------------------------------------------------------------------------------------------------
A0A1D5RHP8/186-407          -----------------------------------HIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHL---ERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLE----HEVDLCRKECPFVIKPKIQR-----------------------------------------------------------------------------------------------------------------------------------------------------
A0A060XZY6/276-487          ---------------------------------------------------AVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLVDIKAASLRTLTSIVHL---ERTPKLSNIIDCTGTASYHGFLPVLVRNCIQAMIDPLMEPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHTGLTIFISRLE----HEVDLSRKECPFVIKPKIQRPNSTV-----------------------------------------------------------------------------------------------------------------------------------------------E
E9PSZ5/260-475              -----------------------------------HIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHL---ERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLE----HEVDLCRKECPFVI-----------------------------------------------------------------------------------------------------------------------------------------------------------
S4RFL5/59-312               HIEQLDKISEIPSEIMESLTKMHGIPKDKQMLLFTHVRLAHGFSNHKKRLQAVQARLHAISILVYSNALQESTNSILYNGLIEELVDLLQIPDKHLMDIKAASLRTLTSIVHL---ERTPKLSSIIDCTGAASYHGFLPVLVRNCIQAMIDPTMEPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHGGLSSFINRLESWPQHEVEICRRECPFV------------------------------------------------------------------------------------------------------------------------------------------------------------
H3BXZ7/241-448              -------------------------------------RLCSLWSMS-FRFLRAPARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLVDIKAASLRTLTSIVHL---ERTPKLSNIIDCTGTASYHGFLPVLVRNCIQAMIDPLMEPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFICRLE----HEVDLSRKE----------------------------------------------------------------------------------------------------------------------------------------------------------------
C3YLJ3/273-481              --------------------------------------------DYRLRLQCVQARLQALSVLVYSAALQDNANTLLYNGLIEELVDVLQLNDTRLTEIKAASLRTLTAIIHL---ERNPKLGNIIDATGAASYHGFLPVLVRSCIHAMTDPNESPFPQPFATALFSFLYHLASYEAGGEALVSCGMMESLLKVINWLGDDQDNIIFVTRAVRVVDLITNLDMTSFQTHSGLSCFINRLE----HEVEICRKECPFVITP---------------------------------------------------------------------------------------------------------------------------------------------------------
H2YZN3/266-628              -------------------------------------------SQHKTRLKCVQARLHAISVLVYTNSVSENIGSILYSGFTEELVDLLQVKDNTLVDIKAAALRTLTSIVHLDCRDRTPRLGAIVDVTGVSQYHGFLPVLVRRCIDSMTKNPE--FPHSFATALFSFLYHLSS-ESGGEALVQSGMMGPLLSVVTNMGDQQEQTTFVTRAVRVIDLITNIDWQAFQAINGLQVFIDRLE----HEVNICKKEAPMACDTIPGASEATSSEGTQCLPQRAALFKSVLNFLKKAISDQAFGEQVRHMMDGTLPNSLKHIIGNVEYYGPALFLLAMEVVTVYVFQEPSLLSSLQDNRLTHVMLHALLVKDPPATREVLASLPNIFSALCINTRGLDAFVKCNPFNRLFHVMLSPE
#=GC scorecons              00000000000000000000000000000000000001100003243255558899989897999676768656889969769999969964955957999969999989899000798979649795995669999999999599669666453579859999999999996957699999966999669969755799697768999999997999997955899655995599399900009996667795755321000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
#=GC scorecons_70           ____________________________________________________********************_******************_*__*_****************___*******_***_**_************_**_*****____***_**************_**************_*****__*************************__***___**__**_***____***_*****_*______________________________________________________________________________________________________________________________________________________________
#=GC scorecons_80           ____________________________________________________*************_*___*___****_*__*****_**__*__*__****_**********___******__***_**___**********_**__*_______***_************_*_*_******__***__**_**__***_***_***************_*__***___**__**_***____***___***_*______________________________________________________________________________________________________________________________________________________________
#=GC scorecons_90           ____________________________________________________*********_***_____*____***_*__*****_**__*__*__****_*****_****____*_*_*__*_*_**___**********_**__*________**_************_*___******__***__**_*____**_*____********_*****_*___**___**__**_***____***_____*________________________________________________________________________________________________________________________________________________________________
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