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CATH Superfamily 1.20.960.50

Cleavage stimulation factor subunit 1, dimerisation domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Cleavage stimulation factor subunit 1, dimerisation domain

This superfamily includes the dimerisation domain found at the N-terminal of cleavage stimulation factor subunit 1 (CSTF1) proteins from eukaryotes. This domain allows for homodimerisation such that the functional state of CSTF1 is a heterohexamer. The cleavage stimulation factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognises U and G/U-rich cis-acting RNA sequence elements and helps to stabilise the cleavage and polyadenylation specificity factor (CPSF) at the polyadenylation site as required for productive RNA cleavage PMID:21233223.

INTERPRO:IPR032028, PFAM:PF16699

GO Diversity

Unique GO annotations
7 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
371 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 7
Taxonomy
Unique Species: 371