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CATH Superfamily 1.20.58.1600

Mediator of RNA polymerase II transcription subunit 22

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Mediator of RNA polymerase II transcription subunit 22

Structural domains comprising this superfamily share the structure of subunit 22 (MED22) of the mediator complex. Mediator is a multiprotein co-activator of RNA polymerase (Pol) II transcription. The subunits form at least three structurally distinct submodules with the head and the middle modules defining a conserved core which directly interacts with RNA polymerase II. MED22 is part of the head domain PMID:21498544

GO Diversity

Unique GO annotations
14 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
978 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 13
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 4
Unique GO: 14
Taxonomy
Unique Species: 978