The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Translation initiation factor eIF-2B, N-terminal domain

Translation initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. The eukaryotic translation initiation factor eIF-2B is a complex which comprises five different subunits, alpha, beta, gamma, delta and epsilon, and catalyses the exchange of eIF-2-bound GDP for GTP PMID:19631657. Structural domains comprising this superfamily share the structure of the N-terminal alpha helical domain of the eukaryotic translation initiation factor (eIF-2B) and are found in initiation factor 2B alpha, beta and delta subunits from eukaryotes; related proteins from archaebacteria and IF-2 from prokaryotes in addition to a subfamily of proteins in eukaryotes, archaea, or eubacteria (INTERPRO:IPR000649).

GO Diversity

Unique GO annotations
28 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
1068 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 8
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 2
Unique GO: 28
Unique Species: 1068