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CATH Superfamily 1.10.645.20

NADH-quinone oxidoreductase, subunit D

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: NADH-quinone oxidoreductase, subunit D

Structural domains comprising this superfamily share the structure of subunit D (NuoD), also known as the 49kDa subunit, of NADH-ubiquinone oxidoreductase (Complex I) which catalyzes the first step of oxidative phosphorylation, the oxidation of NADH by ubiquinone PMID:9684860. Complex I couples this oxidoreduction reaction with an active proton transport across the mitochondrial inner membrane or the bacterial cytoplasmic membrane. This subunit is desginated Nqo4 in Thermus terminology. NuoD/Nqo4/49k is involved in the binding and reduction of Q PMID:20979355.

GO Diversity

Unique GO annotations
29 Unique GO terms

EC Diversity

Unique EC annotations
9 Unique EC terms

Species Diversity

Unique species annotations
11828 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 15
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC: 9
Unique GO: 29
Taxonomy
Unique Species: 11828