The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29442: Cytochrome P450 monooxygenase PikC

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
18 D5E3H2 (/IDA) E3VWI3 (/IDA) E3VWJ9 (/IDA) O34926 (/IDA) O87605 (/IDA) P18326 (/IDA) P48635 (/IDA) P9WPL5 (/IDA) P9WPN5 (/IDA) P9WPP1 (/IDA)
(8 more)
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
12 B4XY99 (/IDA) D5E3H2 (/IDA) O87605 (/IDA) Q00441 (/IDA) Q4KCD5 (/IDA) Q59523 (/IDA) Q7D2E2 (/IDA) Q7D2E3 (/IDA) Q83WF5 (/IDA) Q9FCA6 (/IDA)
(2 more)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
10 D5E3H2 (/IDA) E3VWI3 (/IDA) E3VWJ9 (/IDA) O34926 (/IDA) O87605 (/IDA) Q00441 (/IDA) Q59523 (/IDA) Q6N8N2 (/IDA) Q9FCA6 (/IDA) Q9KZF5 (/IDA)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
6 P18326 (/IDA) P48635 (/IDA) Q59971 (/IDA) Q8VQF6 (/IDA) Q93MI2 (/IDA) Q9ZAU3 (/IDA)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
3 Q84HB6 (/IDA) Q9FCA6 (/IDA) Q9KZF5 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
3 P0A517 (/ISS) P9WPL4 (/ISS) P9WPP2 (/ISS)
Cholesterol 26-hydroxylase activity GO:0031073
Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.
3 P0A517 (/ISS) P9WPL4 (/ISS) P9WPP2 (/ISS)
Cholest-4-en-3-one 26-monooxygenase activity GO:0036199
Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate.
3 P9WPL5 (/IDA) P9WPP1 (/IDA) P9WPP3 (/IDA)
Cholest-4-en-3-one 26-monooxygenase activity GO:0036199
Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate.
3 P0A517 (/ISS) P9WPL4 (/ISS) P9WPP2 (/ISS)
Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor GO:0016636
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein.
2 E3VWI3 (/IDA) E3VWJ9 (/IDA)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen GO:0016713
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor.
2 O34926 (/IDA) Q825I8 (/IDA)
Cholesterol 26-hydroxylase activity GO:0031073
Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.
2 P9WPL5 (/IDA) P9WPP3 (/IDA)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
2 P0A517 (/ISS) P9WPP2 (/ISS)
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
1 P48635 (/IMP)
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
1 Q4KCD5 (/TAS)
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
1 P9WPP1 (/IDA)
Cyclase activity GO:0009975
Catalysis of a ring closure reaction.
1 P9WPP7 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 P9WPP7 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 Q5LX14 (/ISS)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
1 Q9KIZ4 (/NAS)
4-methoxybenzoate monooxygenase (O-demethylating) activity GO:0018690
Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O.
1 Q6N8N2 (/IDA)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
1 P48635 (/IDA)
Carbon monoxide binding GO:0070025
Interacting selectively and non-covalently with carbon monoxide (CO).
1 P9WPP7 (/IDA)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 P9WPP3 (/IDA)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
11 E3VWI3 (/IDA) E3VWJ9 (/IDA) O87605 (/IDA) Q00441 (/IDA) Q59523 (/IDA) Q6N8N2 (/IDA) Q825I8 (/IDA) Q83WF5 (/IDA) Q8VQF6 (/IDA) Q9FCA6 (/IDA)
(1 more)
Antibiotic biosynthetic process GO:0017000
The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
4 B4XY99 (/IDA) Q59523 (/IDA) Q825I8 (/IDA) Q83WF5 (/IDA)
Daunorubicin biosynthetic process GO:1901771
The chemical reactions and pathways resulting in the formation of daunorubicin.
3 Q59971 (/IDA) Q93MI2 (/IDA) Q9ZAU3 (/IDA)
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
2 P9WPL5 (/IDA) P9WPP1 (/IDA)
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
2 P9WPP0 (/IMP) P9WPP1 (/IMP)
Fatty acid omega-oxidation GO:0010430
A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation.
2 P0A517 (/ISS) P9WPP2 (/ISS)
Antibiotic biosynthetic process GO:0017000
The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
2 Q59523 (/IMP) Q83WF5 (/IMP)
Macrolide biosynthetic process GO:0033068
The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.
2 O87605 (/IDA) P48635 (/IDA)
Growth GO:0040007
The increase in size or mass of an entire organism, a part of an organism or a cell.
2 P9WPN7 (/IMP) P9WPP7 (/IMP)
Pigment metabolic process GO:0042440
The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
2 Q9FCA6 (/IDA) Q9KZF5 (/IDA)
Methyl-branched fatty acid metabolic process GO:0097089
The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain.
2 P0A517 (/ISS) P9WPP2 (/ISS)
Pentalenolactone biosynthetic process GO:1901780
The chemical reactions and pathways resulting in the formation of pentalenolactone.
2 E3VWI3 (/IDA) E3VWJ9 (/IDA)
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 P9WPL4 (/ISS)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
1 Q6N8N2 (/IDA)
Fatty acid omega-oxidation GO:0010430
A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation.
1 P9WPP3 (/IDA)
Antibiotic metabolic process GO:0016999
The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
1 Q9ZHQ1 (/IMP)
Macrolide biosynthetic process GO:0033068
The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.
1 P48635 (/IMP)
Novobiocin biosynthetic process GO:0043642
The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase.
1 Q9L9F9 (/IDA)
Growth of symbiont in host GO:0044117
The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P9WPP1 (/IMP)
Doxorubicin metabolic process GO:0044598
The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
1 Q93MI2 (/IDA)
Pigment biosynthetic process GO:0046148
The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.
1 O34926 (/IDA)
Epothilone biosynthetic process GO:0050814
The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer.
1 Q9KIZ4 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P9WPP7 (/IMP)
Vitamin D3 metabolic process GO:0070640
The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.
1 P18326 (/IDA)
Methyl-branched fatty acid metabolic process GO:0097089
The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain.
1 P9WPP3 (/IDA)
Erythromycin biosynthetic process GO:1901115
The chemical reactions and pathways resulting in the formation of erythromycin.
1 Q00441 (/IDA)
Lactone biosynthetic process GO:1901336
The chemical reactions and pathways resulting in the formation of lactone.
1 Q825I8 (/IDA)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
4 P9WPL1 (/IDA) P9WPL5 (/IDA) P9WPM1 (/IDA) P9WPN5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P18326 (/IDA)