The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Death Domain, Fas
".
FunFam 5164: Pyrin and HIN domain-containing protein 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
3 | P0DOV2 (/IDA) Q16666 (/IDA) Q8CGE8 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P0DOV2 (/IPI) Q16666 (/IPI) |
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
|
1 | Q16666 (/IDA) |
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | Q16666 (/IDA) |
Transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q16666 (/IDA) |
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
|
1 | P0DOV2 (/IGI) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q16666 (/IDA) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
|
1 | Q16666 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q16666 (/IPI) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cellular response to interferon-beta GO:0035458
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
|
4 | O35368 (/IDA) P0DOV2 (/IDA) Q8BV49 (/IDA) Q8CGE8 (/IDA) |
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q16666 (/IDA) |
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q16666 (/IMP) |
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
|
1 | Q16666 (/TAS) |
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
|
1 | Q16666 (/IDA) |
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P0DOV2 (/IDA) |
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | Q16666 (/NAS) |
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q16666 (/IEP) |
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
1 | Q16666 (/NAS) |
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
1 | Q16666 (/NAS) |
Monocyte differentiation GO:0030224
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.
|
1 | Q16666 (/IDA) |
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
1 | D0QMC3 (/IMP) |
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | Q16666 (/TAS) |
Positive regulation of interleukin-1 beta production GO:0032731
Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
|
1 | Q16666 (/IDA) |
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
|
1 | Q16666 (/IMP) |
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
|
1 | Q16666 (/IDA) |
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | Q16666 (/IDA) |
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | P0DOV2 (/ISO) |
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
1 | Q16666 (/IDA) |
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
|
1 | Q16666 (/IDA) |
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
|
1 | P0DOV2 (/IGI) |
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
|
1 | Q16666 (/IDA) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q16666 (/IDA) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q16666 (/IDA) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q16666 (/IMP) |
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
|
1 | P0DOV2 (/IDA) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
1 | Q16666 (/IMP) |
Cellular response to ionizing radiation GO:0071479
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
|
1 | Q16666 (/IDA) |
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
1 | Q16666 (/IMP) |
Activation of cysteine-type endopeptidase activity GO:0097202
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.
|
1 | Q16666 (/IMP) |
Negative regulation of cysteine-type endopeptidase activity GO:2000117
Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity.
|
1 | Q16666 (/IDA) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
10 | B2RWU7 (/ISO) D0QMC3 (/ISO) D3Z2E7 (/ISO) E9Q3L4 (/ISO) O35368 (/ISO) P0DOV1 (/ISO) P0DOV2 (/ISO) Q504N7 (/ISO) Q8BV49 (/ISO) Q8CGE8 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | D0QMC3 (/IDA) Q16666 (/IDA) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
2 | P0DOV1 (/ISO) P0DOV2 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q16666 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P0DOV2 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q16666 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q16666 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q16666 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q16666 (/IDA) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q16666 (/IDA) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
1 | P0DOV1 (/ISO) |