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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79529: Glycogen synthase kinase 3

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 200 A0A024R0L5 A0A024R0L5 A0A061HTA5 A0A061HTA5 A0A061HTX7 A0A061HTX7 A0A061I155 A0A061I155 A0A061I4T5 A0A061I4T5
(190 more...)
[Tau protein] kinase. [EC: 2.7.11.26]
ATP + [tau protein] = ADP + [tau protein] phosphate.
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
 180 A0A023B2F7 A0A023B2F7 A0A024R0L5 A0A024R0L5 A0A060RSW8 A0A060RSW8 A0A060T4L0 A0A060T4L0 A0A074SWJ3 A0A074SWJ3
(170 more...)
Dual-specificity kinase. [EC: 2.7.12.1]
ATP + a protein = ADP + a phosphoprotein.
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
 18 A0A0L8VIY8 A0A0L8VIY8 A6ZSH3 A6ZSH3 B3LPE1 B3LPE1 B5VQB3 B5VQB3 C7GWQ4 C7GWQ4
(8 more...)
Cyclin-dependent kinase. [EC: 2.7.11.22]
ATP + a protein = ADP + a phosphoprotein.
  • Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin.
  • It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
  • Formerly EC 2.7.1.37.
 14 A0A061ILI7 A0A061ILI7 C1L3S7 C1L3S7 K0KI34 K0KI34 M2W712 M2W712 Q2QSL4 Q2QSL4
(4 more...)
[RNA-polymerase]-subunit kinase. [EC: 2.7.11.23]
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
  • Appears to be distinct from other protein phosphokinases.
  • Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6.
  • Does not phosphorylate casein, phosvitin or histone.
  • Formerly EC 2.7.1.141.
 10 G0QMC9 G0QMC9 G0QMD1 G0QMD1 G0QME5 G0QME5 G0R634 G0R634 Q2QSL4 Q2QSL4
Riboflavin kinase. [EC: 2.7.1.26]
ATP + riboflavin = ADP + FMN.
  • The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B(6), vitamin B12 and folates.
  • While monofunctional riboflavin kinase is found in eukaryotes, some bacteria have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.7.2.
  • In Bacillus subtilis, ATP can be replaced by other phosphate donors but with decreasing enzyme activity in the order ATP > dATP > CTP > UTP.
 6 A0A1G4IBC5 A0A1G4IBC5 D0A032 D0A032 Q388M1 Q388M1
Mitogen-activated protein kinase. [EC: 2.7.11.24]
ATP + a protein = ADP + a phosphoprotein.
  • Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation.
  • Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline.
  • A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY).
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
 6 G0QMC9 G0QMC9 G0QSW0 G0QSW0 X6MQJ6 X6MQJ6
Transferred entry: 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1. [EC: 2.7.1.37]
    		4 Q4UD13 Q4UD13 Q57XN2 Q57XN2
    Deoxyribonuclease II. [EC: 3.1.22.1]
    Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.
    • Preference for double-stranded DNA.
    • Similar enzymes: crab testis DNase, snail DNase, salmon testis DNase, liver acid DNase, human acid DNases of gastric mucosa and cervix.
    • Formerly EC 3.1.4.6.
    		 2 G0QUS5 G0QUS5
    Peptidylprolyl isomerase. [EC: 5.2.1.8]
    Peptidylproline (omega=180) = peptidylproline (omega=0).
    • The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A.
    • Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli.
    • The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
    		 2 G0QMD1 G0QMD1
    Type 1 galactoside alpha-(1,2)-fucosyltransferase. [EC: 2.4.1.69]
    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N- acetyl-beta-D-glucosaminyl-R.
    • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
    • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
    • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
    • Formerly EC 2.4.1.89.
    		 2 G0QMC9 G0QMC9
    DNA (cytosine-5-)-methyltransferase. [EC: 2.1.1.37]
    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
    • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
    • Formerly EC 2.1.1.73.
    		 2 A0A0K9PW35 A0A0K9PW35
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