The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 78946: Myosin light chain kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 102 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
35 A2A121 (/IPI) A2ASS6 (/IPI) O43293 (/IPI) O54784 (/IPI) O80673 (/IPI) O88764 (/IPI) P08414 (/IPI) P11801 (/IPI) P51812 (/IPI) P53355 (/IPI)
(25 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
33 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) F1R686 (/IDA) O08605 (/IDA)
(23 more)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
28 A0A0B4JCU1 (/IDA) A0A0B4JD64 (/IDA) A0A0B4JD82 (/IDA) A0A0B4KF84 (/IDA) A0A0B4KG35 (/IDA) A1ZA69 (/IDA) A1ZA70 (/IDA) A1ZA72 (/IDA) E9PT87 (/IDA) O01653 (/IDA)
(18 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
27 A0A0B4JCU1 (/NAS) A0A0B4JD64 (/NAS) A0A0B4JD82 (/NAS) A0A0B4KF84 (/NAS) A0A0B4KG35 (/NAS) A1ZA69 (/NAS) A1ZA70 (/NAS) A1ZA72 (/NAS) A4V110 (/NAS) D1YSG0 (/NAS)
(17 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
24 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) E9QHI3 (/IDA) F1R686 (/IDA)
(14 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
20 B3NKK1 (/ISS) B4GXC2 (/ISS) B4IMC3 (/ISS) B4IT27 (/ISS) B4NSS9 (/ISS) B5DK35 (/ISS) P18653 (/ISS) P34101 (/ISS) P62344 (/ISS) Q54CY9 (/ISS)
(10 more)
Myosin light chain kinase activity GO:0004687
Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.
17 A0A0B4JCU1 (/IDA) A0A0B4JD64 (/IDA) A0A0B4JD82 (/IDA) A0A0B4KF84 (/IDA) A0A0B4KG35 (/IDA) A1ZA69 (/IDA) A1ZA70 (/IDA) A1ZA72 (/IDA) O01653 (/IDA) P07313 (/IDA)
(7 more)
Myosin light chain kinase activity GO:0004687
Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.
13 A0A0B4JCU1 (/ISS) A0A0B4JD64 (/ISS) A0A0B4JD82 (/ISS) A0A0B4KF84 (/ISS) A0A0B4KG35 (/ISS) A1ZA69 (/ISS) A1ZA70 (/ISS) A1ZA72 (/ISS) O01653 (/ISS) Q32MK0 (/ISS)
(3 more)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
12 A4V110 (/ISS) Q0KIF7 (/ISS) Q14012 (/ISS) Q32MK0 (/ISS) Q5B8R5 (/ISS) Q7JMV3 (/ISS) Q8IGW6 (/ISS) Q8ILL6 (/ISS) Q91YS8 (/ISS) Q9H1R3 (/ISS)
(2 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
12 O08605 (/IDA) O43293 (/IDA) O54784 (/IDA) O88764 (/IDA) O94768 (/IDA) P53355 (/IDA) Q80YE7 (/IDA) Q8CDB0 (/IDA) Q91XS8 (/IDA) Q9HBH9 (/IDA)
(2 more)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
11 A0A0B4JCU1 (/ISS) A0A0B4JD64 (/ISS) A0A0B4JD82 (/ISS) A0A0B4KF84 (/ISS) A0A0B4KG35 (/ISS) A1ZA69 (/ISS) A1ZA70 (/ISS) A1ZA72 (/ISS) O01653 (/ISS) Q9GV80 (/ISS)
(1 more)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
10 O80673 (/IDA) P07313 (/IDA) P53355 (/IDA) Q63092 (/IDA) Q80YE7 (/IDA) Q8I534 (/IDA) Q9P7I2 (/IDA) Q9TXJ0 (/IDA) Q9UIK4 (/IDA) Q9ZUZ2 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
9 O43293 (/TAS) P51812 (/TAS) P53355 (/TAS) Q15349 (/TAS) Q15418 (/TAS) Q63531 (/TAS) Q91XS8 (/TAS) Q9UIK4 (/TAS) Q9WUT3 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
7 A2ASS6 (/ISO) O08605 (/ISO) O54784 (/ISO) P18653 (/ISO) Q8BG48 (/ISO) Q8CDB0 (/ISO) Q9Z2B9 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
7 O08605 (/ISO) O54784 (/ISO) Q80YE7 (/ISO) Q8BG48 (/ISO) Q8CDB0 (/ISO) Q8VDF3 (/ISO) Q9Z2B9 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
6 Q5ZM34 (/ISS) Q8BG48 (/ISS) Q8VDF3 (/ISS) Q91XS8 (/ISS) Q9GM70 (/ISS) Q9Z2B9 (/ISS)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
6 D1YSG0 (/IDA) L0MN91 (/IDA) L0MPZ1 (/IDA) O76281 (/IDA) Q7KQP6 (/IDA) X2JD89 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 A1Z7Y7 (/IMP) P24719 (/IMP) Q4G050 (/IMP) Q8IDV5 (/IMP) Q95SK9 (/IMP)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
5 A4V110 (/TAS) Q0KIF7 (/TAS) Q7JMV3 (/TAS) Q8IGW6 (/TAS) Q8WZ42 (/TAS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
4 O94768 (/ISS) Q8BG48 (/ISS) Q8IID2 (/ISS) Q8IKX5 (/ISS)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
4 A5X6X5 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP) Q8WZ42 (/IMP)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
4 P51812 (/TAS) Q15349 (/TAS) Q15418 (/TAS) Q9UK32 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
4 P18654 (/IPI) Q21360 (/IPI) Q23551 (/IPI) Q8WZ42 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O43293 (/IPI) P53355 (/IPI) Q8WZ42 (/IPI) Q9UIK4 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 A2ASS6 (/ISO) O54784 (/ISO) Q80YE7 (/ISO) Q8VDF3 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 O15075 (/TAS) P51812 (/TAS) Q9UK32 (/TAS)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
3 P08414 (/ISO) Q80YE7 (/ISO) Q8BW96 (/ISO)
Ribosomal protein S6 kinase activity GO:0004711
Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
3 Q24496 (/IDA) Q9VR61 (/IDA) Q9WUT3 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q8I534 (/IDA) Q8IBS5 (/IDA) Q8WZ42 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 A2ASS6 (/ISO) Q80YE7 (/ISO) Q8VDF3 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 A1Z7Y7 (/IGI) Q95SK9 (/IGI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 Q21360 (/IMP) Q9P7I2 (/IMP)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
2 Q00771 (/IMP) Q8IDV5 (/IMP)
Myosin light chain kinase activity GO:0004687
Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.
2 E9PT87 (/IMP) P20689 (/IMP)
Myosin light chain kinase activity GO:0004687
Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.
2 Q6PDN3 (/ISO) Q8VCR8 (/ISO)
Ribosomal protein S6 kinase activity GO:0004711
Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
2 Q24496 (/ISS) Q9VR61 (/ISS)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 Q15349 (/IDA) Q15418 (/IDA)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P18653 (/ISO) Q9WUT3 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 Q8VDF3 (/ISS) Q9H1R3 (/ISS)
Calcium-dependent protein serine/threonine kinase activity GO:0009931
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions.
2 P62344 (/IDA) Q8ICR0 (/IDA)
Calcium-dependent protein kinase activity GO:0010857
Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium.
2 F1QB45 (/IDA) Q0D715 (/IDA)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 O88764 (/IDA) P18653 (/IDA)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 Q9VGI4 (/IMP) Q9VGI5 (/IMP)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 Q6PDN3 (/IPI) Q8WZ42 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O54784 (/ISS) O88764 (/ISS)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 P51812 (/IDA) Q15418 (/IDA)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 P18653 (/ISO) P18654 (/ISO)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
2 Q9VGI4 (/IPI) Q9VGI5 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 Q8WZ42 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 A2ASS6 (/ISO)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 Q8IBS5 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 Q80YE7 (/ISO)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
1 P08414 (/TAS)
Myosin light chain kinase activity GO:0004687
Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.
1 Q15746 (/TAS)
Ribosomal protein S6 kinase activity GO:0004711
Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
1 Q63531 (/TAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q8WZ42 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 A2ASS6 (/ISO)
Calcium-dependent protein serine/threonine phosphatase activity GO:0004723
Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
1 Q8IBS5 (/IDA)
Signal transducer activity, downstream of receptor GO:0005057
Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.
1 O15075 (/TAS)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 A2ASS6 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 A2ASS6 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 Q9H1R3 (/IC)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P25323 (/IC)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 Q8IID2 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q7PLI7 (/ISS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 O88764 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 Q63531 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 P18653 (/IPI)
CAMP response element binding protein binding GO:0008140
Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein).
1 O43293 (/TAS)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
1 A2ASS6 (/ISO)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
1 Q8WZ42 (/TAS)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 O54784 (/ISO)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q63531 (/ISS)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 G4SLH0 (/IMP)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
1 O43293 (/IDA)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
1 O54784 (/ISO)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
1 P53355 (/IPI)
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
1 Q80YE7 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 A2ASS6 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 A2ASS6 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 Q9M101 (/IPI)
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
1 A2ASS6 (/IPI)
Actin-dependent ATPase activity GO:0030898
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
1 P25323 (/IDA)
Telethonin binding GO:0031433
Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.
1 Q8WZ42 (/IPI)
Telethonin binding GO:0031433
Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.
1 A2ASS6 (/ISO)
Telethonin binding GO:0031433
Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.
1 Q8WZ42 (/ISS)
Myosin light chain binding GO:0032027
Interacting selectively and non-covalently with a light chain of a myosin complex.
1 P20689 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O43293 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 O54784 (/ISO)
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
1 Q8WZ42 (/IDA)
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
1 Q8WZ42 (/IPI)
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
1 A2ASS6 (/ISO)
Leucine zipper domain binding GO:0043522
Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
1 O43293 (/IPI)
Leucine zipper domain binding GO:0043522
Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
1 O54784 (/ISO)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 Q8WZ42 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 A2ASS6 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q8WZ42 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 G4SLH0 (/IPI)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 A2ASS6 (/ISO)
Muscle alpha-actinin binding GO:0051371
Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
1 Q8WZ42 (/IPI)
Muscle alpha-actinin binding GO:0051371
Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
1 A2ASS6 (/ISO)
Structural molecule activity conferring elasticity GO:0097493
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.
1 Q8WZ42 (/TAS)

There are 435 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
44 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) E9PT87 (/IDA) F1R686 (/IDA)
(34 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
36 A0A0B4JCU1 (/ISS) A0A0B4JD64 (/ISS) A0A0B4JD82 (/ISS) A0A0B4KF84 (/ISS) A0A0B4KG35 (/ISS) A1ZA69 (/ISS) A1ZA70 (/ISS) A1ZA72 (/ISS) A4V110 (/ISS) B3NKK1 (/ISS)
(26 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
27 A0A0B4JCU1 (/NAS) A0A0B4JD64 (/NAS) A0A0B4JD82 (/NAS) A0A0B4KF84 (/NAS) A0A0B4KG35 (/NAS) A1ZA69 (/NAS) A1ZA70 (/NAS) A1ZA72 (/NAS) A4V110 (/NAS) D1YSG0 (/NAS)
(17 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
20 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) F1R686 (/IDA) O43293 (/IDA)
(10 more)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
18 A0A0B4JCU1 (/IMP) A0A0B4JD64 (/IMP) A0A0B4JD82 (/IMP) A0A0B4KF84 (/IMP) A0A0B4KG35 (/IMP) A1Z7Y7 (/IMP) A1ZA69 (/IMP) A1ZA70 (/IMP) A1ZA72 (/IMP) A4V110 (/IMP)
(8 more)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
13 O08605 (/IDA) O43293 (/IDA) O54784 (/IDA) O88764 (/IDA) O94768 (/IDA) P53355 (/IDA) Q80YE7 (/IDA) Q8CDB0 (/IDA) Q91XS8 (/IDA) Q9GM70 (/IDA)
(3 more)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
12 A2ASS6 (/IMP) A5X6X5 (/IMP) D1YSG0 (/IMP) E9PT87 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP) L0MN91 (/IMP) L0MPZ1 (/IMP) O76281 (/IMP) Q7KQP6 (/IMP)
(2 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
9 A0A0G2KD98 (/IPI) A0A0G2KZL6 (/IPI) A0A0G2L8W3 (/IPI) A2A121 (/IPI) A2A123 (/IPI) A2A124 (/IPI) A2A125 (/IPI) B5DE25 (/IPI) F1R686 (/IPI)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
9 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) F1R686 (/IDA)
Sarcomerogenesis GO:0048769
The process in which sarcomeres are added in series within a fiber.
9 A5X6X5 (/IMP) A5X6X6 (/IMP) A8C984 (/IMP) E9PT87 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP) G1K2X0 (/IMP) Q7ZZ46 (/IMP) Q8WZ42 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
8 O08605 (/ISO) O54784 (/ISO) Q80YE7 (/ISO) Q8BG48 (/ISO) Q8CDB0 (/ISO) Q8VDF3 (/ISO) Q91YS8 (/ISO) Q9Z2B9 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
7 O08605 (/ISO) O54784 (/ISO) Q80YE7 (/ISO) Q8BG48 (/ISO) Q8CDB0 (/ISO) Q8VDF3 (/ISO) Q9Z2B9 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 O15075 (/TAS) P53355 (/TAS) Q14012 (/TAS) Q15746 (/TAS) Q16566 (/TAS) Q9HBH9 (/TAS)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
6 D1YSG0 (/IEP) L0MN91 (/IEP) L0MPZ1 (/IEP) O76281 (/IEP) Q7KQP6 (/IEP) X2JD89 (/IEP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
6 A5X6X5 (/IGI) A5X6X6 (/IGI) F1QZQ0 (/IGI) F1R7N8 (/IGI) G1K2X0 (/IGI) Q7ZZ46 (/IGI)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
6 A5X6X5 (/IGI) A5X6X6 (/IGI) F1QZQ0 (/IGI) F1R7N8 (/IGI) G1K2X0 (/IGI) Q7ZZ46 (/IGI)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
6 Q5ZM34 (/ISS) Q8BG48 (/ISS) Q8VDF3 (/ISS) Q91XS8 (/ISS) Q9GM70 (/ISS) Q9Z2B9 (/ISS)
Sarcomerogenesis GO:0048769
The process in which sarcomeres are added in series within a fiber.
6 A5X6X5 (/IGI) A5X6X6 (/IGI) F1QZQ0 (/IGI) F1R7N8 (/IGI) G1K2X0 (/IGI) Q7ZZ46 (/IGI)
Striated muscle myosin thick filament assembly GO:0071688
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.
6 A5X6X5 (/IGI) A5X6X6 (/IGI) F1QZQ0 (/IGI) F1R7N8 (/IGI) G1K2X0 (/IGI) Q7ZZ46 (/IGI)
Muscle thin filament assembly GO:0071689
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle.
6 D1YSG0 (/IMP) L0MN91 (/IMP) L0MPZ1 (/IMP) O76281 (/IMP) Q7KQP6 (/IMP) X2JD89 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 P08414 (/IMP) P20689 (/IMP) Q00771 (/IMP) Q21360 (/IMP) Q8IDV5 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
5 O43293 (/IMP) O88764 (/IMP) P53355 (/IMP) Q91XS8 (/IMP) Q9GM70 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
5 P51812 (/TAS) Q14012 (/TAS) Q15418 (/TAS) Q16566 (/TAS) Q9UK32 (/TAS)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
5 Q23551 (/IDA) Q6PGN3 (/IDA) Q8BWQ5 (/IDA) Q9JLM8 (/IDA) Q9WUT3 (/IDA)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
5 A0A0A0MPL6 (/IMP) F1QB46 (/IMP) Q24496 (/IMP) Q6P965 (/IMP) Q9VR61 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
4 A5X6X5 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP) Q91YA2 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
4 O43293 (/IDA) O88764 (/IDA) Q15349 (/IDA) Q8BW96 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P51812 (/IMP) Q14012 (/IMP) Q15418 (/IMP) Q9TXJ0 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P18653 (/ISO) P18654 (/ISO) Q91YS8 (/ISO) Q9Z2B9 (/ISO)
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
4 Q24496 (/IGI) Q9VGI4 (/IGI) Q9VGI5 (/IGI) Q9VR61 (/IGI)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
4 O54784 (/ISS) O88764 (/ISS) O94768 (/ISS) Q8BG48 (/ISS)
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
3 P34101 (/ISS) Q54MH0 (/ISS) Q54VI1 (/ISS)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
3 A5X6X5 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 A1Z7Y7 (/IGI) Q91YS8 (/IGI) Q95SK9 (/IGI)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
3 P34101 (/ISS) Q54MH0 (/ISS) Q54VI1 (/ISS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
3 O15075 (/TAS) P51812 (/TAS) Q9UK32 (/TAS)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
3 A5X6X5 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
3 A0A140LFR4 (/IMP) A8C985 (/IMP) F1R221 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
3 Q24496 (/IMP) Q8I113 (/IMP) Q9VR61 (/IMP)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
3 O43293 (/TAS) P53355 (/TAS) Q9UIK4 (/TAS)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 Q63450 (/ISS) Q8IU85 (/ISS) Q91YS8 (/ISS)
Skeletal myofibril assembly GO:0014866
The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.
3 A5X6X6 (/IMP) G1K2X0 (/IMP) Q7ZZ46 (/IMP)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
3 Q14012 (/IMP) Q9VGI4 (/IMP) Q9VGI5 (/IMP)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
3 Q21360 (/IGI) Q23551 (/IGI) Q8I113 (/IGI)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
3 Q21360 (/IMP) Q23551 (/IMP) Q8I113 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
3 O43293 (/TAS) P53355 (/TAS) Q9UIK4 (/TAS)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
3 A0A0R4ID09 (/IGI) B0R0M9 (/IGI) Q7ZVH8 (/IGI)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 A1Z7Y7 (/IMP) Q21360 (/IMP) Q95SK9 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 O54784 (/ISO) Q80YE7 (/ISO) Q8VCR8 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 O43293 (/TAS) P53355 (/TAS) Q9UIK4 (/TAS)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
3 P08414 (/IDA) Q14012 (/IDA) Q91YS8 (/IDA)
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
3 A0A0R4ID09 (/IMP) B0R0M9 (/IMP) Q7ZVH8 (/IMP)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
3 A5X6X5 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP)
Cardiac myofibril assembly GO:0055003
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
3 A2ASS6 (/IMP) E9PT87 (/IMP) Q8WZ42 (/IMP)
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
3 A2ASS6 (/IMP) Q8WZ42 (/IMP) Q9H1R3 (/IMP)
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
3 A5X6X5 (/IMP) F1QZQ0 (/IMP) F1R7N8 (/IMP)
Negative regulation of protein localization to nucleus GO:1900181
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
3 Q6PGN3 (/IDA) Q8BWQ5 (/IDA) Q9JLM8 (/IDA)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
3 A0A140LFR4 (/IGI) A8C985 (/IGI) F1R221 (/IGI)
Positive regulation of fibroblast apoptotic process GO:2000271
Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.
3 Q5ZM34 (/ISS) Q8BG48 (/ISS) Q91XS8 (/ISS)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 A2ASS6 (/IMP) A8C984 (/IMP)
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
2 P08414 (/IDA) Q91YS8 (/IDA)
Autophagy GO:0006914
The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
2 A1Z7Y7 (/IMP) Q95SK9 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2 O54784 (/ISO) Q80YE7 (/ISO)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
2 Q15746 (/TAS) Q8WZ42 (/TAS)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
2 Q9VGI4 (/IMP) Q9VGI5 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P08414 (/IDA) Q91YS8 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P22517 (/NAS) Q15349 (/NAS)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
2 Q24496 (/IMP) Q9VR61 (/IMP)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
2 Q24496 (/IMP) Q9VR61 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 P08414 (/ISS) P13234 (/ISS)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
2 Q24496 (/IMP) Q9VR61 (/IMP)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
2 Q24496 (/TAS) Q9VR61 (/TAS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 Q21360 (/IMP) Q23551 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
2 Q93VK0 (/IDA) Q9SPK4 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9H1R3 (/IDA) Q9WUT3 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 A2ASS6 (/ISO) Q8VCR8 (/ISO)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
2 O43293 (/IDA) P53355 (/IDA)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
2 O54784 (/ISO) Q80YE7 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 P20689 (/TAS) P51812 (/TAS)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
2 Q23551 (/IDA) Q9H1R3 (/IDA)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 P51812 (/TAS) Q15418 (/TAS)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
2 Q9VGI4 (/IEP) Q9VGI5 (/IEP)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
2 Q59XV1 (/IMP) Q5ANJ0 (/IMP)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
2 A1Z7Y7 (/IGI) Q95SK9 (/IGI)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
2 Q8IU85 (/IDA) Q9TXJ0 (/IDA)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
2 Q63450 (/ISS) Q91YS8 (/ISS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q59XV1 (/IMP) Q5ANJ0 (/IMP)
Operant conditioning GO:0035106
Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
2 Q24496 (/IMP) Q9VR61 (/IMP)
Operant conditioning GO:0035106
Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
2 Q24496 (/TAS) Q9VR61 (/TAS)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
2 Q9VGI4 (/IMP) Q9VGI5 (/IMP)
Negative regulation of protein import into nucleus GO:0042308
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
2 Q24496 (/IDA) Q9VR61 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P62344 (/IDA) Q8IDV5 (/IDA)
Negative regulation of compound eye cone cell fate specification GO:0042683
Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell.
2 Q24496 (/IMP) Q9VR61 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
2 B5MF71 (/IMP) B5MF72 (/IMP)
Myeloid dendritic cell differentiation GO:0043011
The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
2 P08414 (/ISS) P13234 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 O54784 (/ISO) Q9WUT3 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 Q9GM70 (/ISS) Q9WUT3 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q15418 (/IMP) Q80YE7 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P18653 (/ISS) Q63531 (/ISS)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
2 P51812 (/IDA) Q15418 (/IDA)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
2 P18653 (/ISO) P18654 (/ISO)
Regulation of protein binding GO:0043393
Any process that modulates the frequency, rate or extent of protein binding.
2 Q63450 (/ISS) Q91YS8 (/ISS)
Regulation of translation in response to stress GO:0043555
Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
2 P51812 (/TAS) Q15418 (/TAS)
Regulation of DNA-templated transcription in response to stress GO:0043620
Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
2 P51812 (/TAS) Q15418 (/TAS)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
2 P51812 (/TAS) Q15418 (/TAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q16566 (/IDA) Q63531 (/IDA)
Negative regulation of photoreceptor cell differentiation GO:0046533
Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.
2 Q24496 (/IMP) Q9VR61 (/IMP)
Response to cycloheximide GO:0046898
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.
2 Q93VK0 (/IDA) Q9SPK4 (/IDA)
Negative regulation of pigment cell differentiation GO:0050941
Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation.
2 Q24496 (/IMP) Q9VR61 (/IMP)
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
2 Q63450 (/ISS) Q91YS8 (/ISS)
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
2 Q63450 (/ISS) Q91YS8 (/ISS)
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
2 A2ASS6 (/ISO) Q8VCR8 (/ISO)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
2 Q63450 (/ISS) Q91YS8 (/ISS)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 O43293 (/IDA) P53355 (/IDA)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 O54784 (/IMP) Q80YE7 (/IMP)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 O54784 (/ISO) Q80YE7 (/ISO)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
2 Q63450 (/ISS) Q91YS8 (/ISS)
Hepatocyte proliferation GO:0072574
The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
2 Q15418 (/ISS) Q63531 (/ISS)
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
2 Q8BW96 (/IMP) Q9UIK4 (/IMP)
Extrinsic apoptotic signaling pathway in absence of ligand GO:0097192
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
2 O08605 (/IGI) Q8CDB0 (/IGI)
Extrinsic apoptotic signaling pathway in absence of ligand GO:0097192
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
2 O08605 (/IMP) Q8CDB0 (/IMP)
Regulation of neuromuscular junction development GO:1904396
Any process that modulates the frequency, rate or extent of neuromuscular junction development.
2 Q24496 (/IMP) Q9VR61 (/IMP)
Positive regulation of fibroblast apoptotic process GO:2000271
Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.
2 O94768 (/IMP) Q9UEE5 (/IMP)
Positive regulation of hepatic stellate cell activation GO:2000491
Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.
2 P18653 (/ISS) Q63531 (/ISS)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
1 Q00771 (/IMP)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9P7I2 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q6PGN3 (/IDA)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 P25323 (/IMP)
Cytokinesis GO:0000910
The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
1 O43293 (/TAS)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
1 P51812 (/TAS)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
1 Q9WUT3 (/IDA)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 A2ASS6 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 A2ASS6 (/IEP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q9JLM8 (/IGI)
Brain renin-angiotensin system GO:0002035
The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.
1 Q9WUT3 (/IDA)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 P18654 (/IMP)
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 P51812 (/ISS)
Regulation of vascular permeability involved in acute inflammatory response GO:0002528
Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.
1 Q32MK0 (/IMP)
Regulation of vascular permeability involved in acute inflammatory response GO:0002528
Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.
1 Q3UIZ8 (/ISO)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 Q8WZ42 (/TAS)
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
1 Q8WZ42 (/IMP)
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
1 A2ASS6 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9Z2B9 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9Z2B9 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 O43293 (/TAS)
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
1 Q4G050 (/IMP)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P20689 (/IMP)
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
1 Q91YS8 (/IGI)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 O43293 (/IDA)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 P53355 (/IGI)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q9UIK4 (/TAS)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 P20689 (/IEP)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 A2ASS6 (/IMP)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 Q8WZ42 (/NAS)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
1 P20689 (/IMP)
Smooth muscle contraction GO:0006939
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
1 Q6PDN3 (/IMP)
Smooth muscle contraction GO:0006939
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
1 Q15746 (/ISS)
Regulation of smooth muscle contraction GO:0006940
Any process that modulates the frequency, rate or extent of smooth muscle contraction.
1 O43293 (/TAS)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
1 Q9H1R3 (/IDA)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
1 Q8VCR8 (/ISO)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
1 Q8WZ42 (/TAS)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
1 Q9UK32 (/IMP)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
1 Q7TPS0 (/ISO)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
1 Q7TPS0 (/ISS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 P13234 (/TAS)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
1 Q7PLI7 (/ISS)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 Q9VCL7 (/IMP)
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
1 Q8WZ42 (/IEP)
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
1 O43293 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P27466 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q9HBH9 (/TAS)
Neuron-neuron synaptic transmission GO:0007270
The process of communication from a neuron to another neuron across a synapse.
1 P08414 (/IMP)
Neuromuscular synaptic transmission GO:0007274
The process of communication from a neuron to a muscle, across a synapse.
1 Q8VCR8 (/IGI)
Neuromuscular synaptic transmission GO:0007274
The process of communication from a neuron to a muscle, across a synapse.
1 Q8VCR8 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 O43293 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 O54784 (/ISO)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
1 Q91YA2 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O15075 (/TAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 Q9JLM8 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q9JLM8 (/IGI)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q9WUT3 (/IDA)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 A2ASS6 (/IEP)
Adult heart development GO:0007512
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
1 A2ASS6 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 Q16566 (/IGI)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 P08414 (/ISO)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q15349 (/IDA)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9WUT3 (/ISO)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9WUT3 (/ISS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q8I113 (/IGI)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 O54784 (/IMP)
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
1 Q80YE7 (/IGI)
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
1 Q80YE7 (/IMP)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
1 O15075 (/IEP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 O08605 (/IDA)
Response to salicylic acid GO:0009751
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.
1 Q9S9V0 (/IEP)
Leaf senescence GO:0010150
The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism.
1 Q9ZUZ2 (/IEP)
Heat acclimation GO:0010286
Any process that increases heat tolerance of an organism in response to high temperatures.
1 O80673 (/IMP)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P53355 (/IMP)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q80YE7 (/ISO)
Negative regulation of transcription by transcription factor localization GO:0010621
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.
1 Q9P7I2 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8WZ42 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8WZ42 (/IMP)
Cardiac muscle cell apoptotic process GO:0010659
A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 Q9WUT3 (/IDA)
Protein kinase A signaling GO:0010737
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
1 Q8WZ42 (/IMP)
Protein kinase A signaling GO:0010737
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
1 A2ASS6 (/ISO)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any cell cycle regulatory process that decreases the rate or extent of progression of a cell from G2 to M phase of the mitotic cell cycle.
1 Q9P7I2 (/IGI)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q14012 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q8BW96 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q91YS8 (/ISO)
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
1 Q91XS8 (/IDA)
Skeletal muscle satellite cell differentiation GO:0014816
The process in which a relatively unspecialized cell acquires specialized features of a satellite cell.
1 Q8VCR8 (/IMP)
Tonic smooth muscle contraction GO:0014820
A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction.
1 Q6PDN3 (/IMP)
Tonic smooth muscle contraction GO:0014820
A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction.
1 Q15746 (/ISS)
Cellular response to phosphate starvation GO:0016036
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
1 Q93VK0 (/IEP)
Endosomal transport GO:0016197
The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.
1 O15075 (/NAS)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 Q4G050 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 O08605 (/ISO)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 Q8VCR8 (/ISO)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q7TNJ7 (/NAS)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 P25323 (/IDA)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
1 P25323 (/IDA)
Ventricular system development GO:0021591
The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
1 A2ASS6 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q6PGN3 (/IGI)
Pyramidal neuron development GO:0021860
The progression of a pyramidal neuron from its initial formation to its mature state.
1 Q6PGN3 (/IGI)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
1 Q9JLM8 (/IGI)
Molting cycle process GO:0022404
A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin.
1 W0LYS5 (/IEP)
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
1 Q8WZ42 (/TAS)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q9HBH9 (/IDA)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q8CDB0 (/ISO)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 O88764 (/IEP)
Skeletal muscle thin filament assembly GO:0030240
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.
1 Q8WZ42 (/IMP)
Skeletal muscle thin filament assembly GO:0030240
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.
1 A2ASS6 (/ISO)
Skeletal muscle myosin thick filament assembly GO:0030241
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.
1 Q8WZ42 (/IMP)
Skeletal muscle myosin thick filament assembly GO:0030241
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.
1 A2ASS6 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q15746 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 O54784 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q6PDN3 (/ISO)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 Q9JLM8 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
1 F1QB45 (/IMP)
Positive regulation of fast-twitch skeletal muscle fiber contraction GO:0031448
Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction.
1 P20689 (/IMP)
Bleb assembly GO:0032060
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
1 Q15746 (/IMP)
Bleb assembly GO:0032060
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
1 Q6PDN3 (/ISO)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q14012 (/IDA)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q91YS8 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P18654 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P51812 (/ISS)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
1 Q8BW96 (/ISO)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
1 Q8BW96 (/ISS)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 Q14012 (/IDA)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
1 Q91YS8 (/ISO)
Regulation of muscle filament sliding GO:0032971
Any process that modulates the frequency, rate or extent of muscle filament sliding.
1 P07313 (/IC)
Regulation of muscle filament sliding GO:0032971
Any process that modulates the frequency, rate or extent of muscle filament sliding.
1 Q9H1R3 (/IDA)
Regulation of muscle filament sliding GO:0032971
Any process that modulates the frequency, rate or extent of muscle filament sliding.
1 Q8VCR8 (/ISO)
Regulation of T cell differentiation in thymus GO:0033081
Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus.
1 Q16566 (/TAS)
Positive regulation of histone phosphorylation GO:0033129
Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.
1 Q9Z2B9 (/ISO)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 Q91YS8 (/ISO)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
1 Q9Z2B9 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q15349 (/TAS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q6PDN3 (/IDA)
Cellular response to potassium ion GO:0035865
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
1 Q6PDN3 (/IDA)
Exit from host cell GO:0035891
The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q8IDV5 (/IMP)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
1 Q9H1R3 (/IDA)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
1 Q8VCR8 (/ISO)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
1 Q8VCR8 (/NAS)
Detection of muscle stretch GO:0035995
The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.
1 Q8WZ42 (/IDA)
Detection of muscle stretch GO:0035995
The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.
1 A2ASS6 (/ISO)
Detection of muscle stretch GO:0035995
The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.
1 Q8WZ42 (/TAS)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
1 Q23551 (/IGI)
Thermosensory behavior GO:0040040
Behavior that is dependent upon the sensation of temperature.
1 Q9TXJ0 (/IMP)
Myeloid dendritic cell differentiation GO:0043011
The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
1 Q16566 (/IMP)
Myeloid dendritic cell differentiation GO:0043011
The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
1 P08414 (/ISO)
Forward locomotion GO:0043056
Anterior movement of an organism, following the direction of the head of the animal.
1 A2ASS6 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q9UEE5 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q8BW96 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P18653 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P51812 (/TAS)
Anoikis GO:0043276
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
1 Q9UIK4 (/IMP)
Anoikis GO:0043276
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
1 Q8VDF3 (/ISO)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 P53355 (/IDA)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q80YE7 (/ISO)
Regulation of protein binding GO:0043393
Any process that modulates the frequency, rate or extent of protein binding.
1 Q14012 (/IDA)
Regulation of protein binding GO:0043393
Any process that modulates the frequency, rate or extent of protein binding.
1 Q91YS8 (/ISO)
Regulation of MAPK cascade GO:0043408
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
1 P20689 (/IMP)
Regulation of myosin II filament organization GO:0043519
Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.
1 O54784 (/IMP)
Histone H3-S10 phosphorylation GO:0043987
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.
1 Q9Z2B9 (/ISO)
Histone H3-S10 phosphorylation GO:0043987
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.
1 Q9Z2B9 (/ISS)
Histone H3-S28 phosphorylation GO:0043988
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.
1 Q9Z2B9 (/ISO)
Histone H3-S28 phosphorylation GO:0043988
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.
1 Q9Z2B9 (/ISS)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q3UIZ8 (/IDA)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 A2ASS6 (/ISO)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q32MK0 (/ISS)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 A2ASS6 (/TAS)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
1 Q9TXJ0 (/IMP)
Regulation of osteoclast differentiation GO:0045670
Any process that modulates the frequency, rate or extent of osteoclast differentiation.
1 Q16566 (/TAS)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 Q15349 (/IDA)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 Q9WUT3 (/ISO)
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
1 Q9WUT3 (/ISS)
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
1 Q9VCL7 (/IMP)
Negative regulation of meiotic nuclear division GO:0045835
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
1 Q9WUT3 (/IDA)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
1 Q8WZ42 (/IMP)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
1 A2ASS6 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P08414 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P08414 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P13234 (/ISS)
Positive regulation of striated muscle contraction GO:0045989
Any process that activates or increases the frequency, rate or extent of striated muscle contraction.
1 Q23551 (/IGI)
Negative regulation of embryonic development GO:0045992
Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.
1 Q7TPS0 (/IDA)
Negative regulation of embryonic development GO:0045992
Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.
1 Q9UK32 (/ISS)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 F4JGW8 (/IEP)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
1 Q91YS8 (/ISO)
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 P20689 (/IMP)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 P20689 (/IMP)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
1 Q9JLM8 (/IGI)
Cardiac muscle fiber development GO:0048739
The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.
1 Q8WZ42 (/IMP)
Cardiac muscle fiber development GO:0048739
The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.
1 A2ASS6 (/ISO)
Sarcomerogenesis GO:0048769
The process in which sarcomeres are added in series within a fiber.
1 A2ASS6 (/ISO)
Sarcomerogenesis GO:0048769
The process in which sarcomeres are added in series within a fiber.
1 Q32MK0 (/ISS)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 Q9TXJ0 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.
1 Q9JLM8 (/IGI)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q8WZ42 (/IGI)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q8WZ42 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 A2ASS6 (/ISO)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q8IU85 (/IMP)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q8BW96 (/ISO)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q8BW96 (/ISS)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
1 Q8IU85 (/IMP)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
1 Q8BW96 (/ISO)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
1 Q8BW96 (/ISS)
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
1 Q8WZ42 (/IMP)
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
1 A2ASS6 (/ISO)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
1 Q0D715 (/IDA)
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
1 P25323 (/IMP)
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
1 Q14012 (/IDA)
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
1 Q91YS8 (/ISO)
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
1 Q14012 (/IMP)
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
1 Q91YS8 (/ISO)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
1 F1QB45 (/IMP)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
1 P24719 (/IMP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q8WZ42 (/IDA)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 A2ASS6 (/ISO)
Meiotic recombination checkpoint GO:0051598
A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.
1 P24719 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 P20689 (/IMP)
Negative regulation of cell division GO:0051782
Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
1 Q23551 (/IGI)
Regulation of nuclear division GO:0051783
Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
1 Q5B8R5 (/IMP)
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
1 Q14012 (/IMP)
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
1 Q91YS8 (/ISO)
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
1 O43293 (/IDA)
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
1 O54784 (/ISO)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q15746 (/IDA)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6PDN3 (/ISO)
Striated muscle cell development GO:0055002
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
1 A2ASS6 (/IMP)
Cardiac myofibril assembly GO:0055003
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
1 A2ASS6 (/ISO)
Cardiac myofibril assembly GO:0055003
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
1 Q32MK0 (/ISS)
Ventricular cardiac myofibril assembly GO:0055005
The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
1 A8C984 (/IMP)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 Q8VCR8 (/NAS)
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 Q9WUT3 (/IDA)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 Q9H1R3 (/IC)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 Q8WZ42 (/IMP)
Cardiac muscle contraction GO:0060048
Muscle contraction of cardiac muscle tissue.
1 A2ASS6 (/ISO)
Positive regulation of syncytium formation by plasma membrane fusion GO:0060143
Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
1 Q14012 (/IMP)
Positive regulation of syncytium formation by plasma membrane fusion GO:0060143
Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
1 Q91YS8 (/ISO)
Definitive hemopoiesis GO:0060216
A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
1 Q568I9 (/IMP)
Positive regulation of respiratory burst GO:0060267
Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
1 Q8IU85 (/IMP)
Positive regulation of respiratory burst GO:0060267
Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
1 Q8BW96 (/ISO)
Positive regulation of respiratory burst GO:0060267
Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
1 Q8BW96 (/ISS)
Positive regulation of sarcomere organization GO:0060298
Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 E9PT87 (/IDA)
Positive regulation of sarcomere organization GO:0060298
Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q23551 (/IMP)
Positive regulation of sarcomere organization GO:0060298
Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q32MK0 (/ISS)
Aorta smooth muscle tissue morphogenesis GO:0060414
The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
1 Q15746 (/IMP)
Aorta smooth muscle tissue morphogenesis GO:0060414
The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
1 Q6PDN3 (/ISO)
Heart growth GO:0060419
The increase in size or mass of the heart.
1 A2ASS6 (/IMP)
Regulation of protein deneddylation GO:0060625
Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein.
1 Q8I113 (/IGI)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 Q14012 (/IMP)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 Q91YS8 (/ISO)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q7TPS0 (/IDA)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q9UK32 (/ISS)
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9Z2B9 (/ISO)
Regulation of protein processing GO:0070613
Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.
1 Q9WUT3 (/IDA)
Regulation of protein processing GO:0070613
Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.
1 Q9WUT3 (/IMP)
Cellular response to abscisic acid stimulus GO:0071215
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
1 Q9ZUZ2 (/IEP)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 Q9HBH9 (/IDA)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
1 Q8CDB0 (/ISO)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q6PDN3 (/IDA)
Cellular response to carbohydrate stimulus GO:0071322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
1 Q9WUT3 (/IDA)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q32MK0 (/IMP)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q3UIZ8 (/ISO)
Cellular response to hydroperoxide GO:0071447
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
1 P53355 (/IMP)
Cellular response to hydroperoxide GO:0071447
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
1 Q80YE7 (/ISO)
Cellular hypotonic response GO:0071476
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
1 Q15746 (/IDA)
Cellular hypotonic response GO:0071476
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
1 Q6PDN3 (/ISO)
Regulation of granulocyte chemotaxis GO:0071622
Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.
1 Q8IU85 (/IMP)
Regulation of granulocyte chemotaxis GO:0071622
Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.
1 Q8BW96 (/ISO)
Regulation of granulocyte chemotaxis GO:0071622
Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.
1 Q8BW96 (/ISS)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
1 Q14012 (/IDA)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
1 Q91YS8 (/ISO)
Hepatocyte proliferation GO:0072574
The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
1 P18653 (/IDA)
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 Q8VDF3 (/ISO)
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 Q8IU85 (/ISS)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 O43293 (/IMP)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 O54784 (/ISO)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
1 Q15746 (/IDA)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
1 Q6PDN3 (/ISO)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 O54784 (/IDA)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 O54784 (/IGI)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 P53355 (/IMP)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 Q80YE7 (/ISO)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 Q80YE7 (/TAS)
Extrinsic apoptotic signaling pathway in absence of ligand GO:0097192
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
1 Q80YE7 (/TAS)
Calcineurin-mediated signaling GO:0097720
Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.
1 Q9P7I2 (/IMP)
Negative regulation of defense response to bacterium GO:1900425
Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.
1 Q9FKW4 (/IDA)
Regulation of relaxation of cardiac muscle GO:1901897
Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle.
1 A2ASS6 (/IMP)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
1 Q14012 (/IMP)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
1 Q91YS8 (/ISO)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
1 Q80YE7 (/IDA)
Neutrophil migration GO:1990266
The movement of an neutrophil within or between different tissues and organs of the body.
1 Q8VDF3 (/IMP)
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
1 F1QB45 (/IMP)
Regulation of secondary shoot formation GO:2000032
Any process that modulates the frequency, rate or extent of secondary shoot formation.
1 Q9FKW4 (/IMP)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
1 O43293 (/TAS)
Regulation of actin cytoskeleton reorganization GO:2000249
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
1 O43293 (/IDA)
Regulation of actin cytoskeleton reorganization GO:2000249
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
1 O54784 (/ISO)
Regulation of actin cytoskeleton reorganization GO:2000249
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
1 O43293 (/TAS)
Positive regulation of fibroblast apoptotic process GO:2000271
Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.
1 Q8BG48 (/ISO)
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
1 Q80YE7 (/IMP)
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
1 P53355 (/ISS)
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
1 Q9UEE5 (/IMP)
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
1 Q9GM70 (/ISS)
Negative regulation of mesoderm development GO:2000381
Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.
1 Q7TPS0 (/IDA)
Negative regulation of mesoderm development GO:2000381
Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.
1 Q9UK32 (/ISS)
Positive regulation of eosinophil chemotaxis GO:2000424
Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis.
1 Q9UIK4 (/IMP)
Positive regulation of eosinophil chemotaxis GO:2000424
Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis.
1 Q8VDF3 (/ISO)
Positive regulation of hepatic stellate cell activation GO:2000491
Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.
1 Q15418 (/IMP)
Positive regulation of hepatic stellate cell activation GO:2000491
Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.
1 P18653 (/ISO)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 O88764 (/IMP)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q9UIK4 (/IMP)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q8VDF3 (/ISO)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q8VDF3 (/ISS)

There are 84 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
32 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) E9PGT3 (/IDA) E9QHI3 (/IDA)
(22 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
30 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) E9QHI3 (/IDA) F1R686 (/IDA)
(20 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
17 O80673 (/IDA) P53355 (/IDA) P62344 (/IDA) Q0D715 (/IDA) Q1PFH8 (/IDA) Q7XJR9 (/IDA) Q8RWL2 (/IDA) Q91VB2 (/IDA) Q9FIM9 (/IDA) Q9FKW4 (/IDA)
(7 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 B5MF71 (/IDA) B5MF72 (/IDA) E9PGT3 (/IDA) E9PT87 (/IDA) Q00771 (/IDA) Q15418 (/IDA) Q568I9 (/IDA) Q9P7I2 (/IDA) Q9VGI4 (/IDA) Q9VGI5 (/IDA)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 G1U9Q7 (/TAS) P13234 (/TAS) P51812 (/TAS) Q15349 (/TAS) Q15418 (/TAS) Q15746 (/TAS) Q16566 (/TAS) Q63531 (/TAS) Q80YE7 (/TAS) Q8WZ42 (/TAS)
(1 more)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
10 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) F1R686 (/IDA) P20689 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 O54784 (/ISO) P18653 (/ISO) Q7TPS0 (/ISO) Q8BG48 (/ISO) Q8BW96 (/ISO) Q8CDB0 (/ISO) Q8VCR8 (/ISO) Q9WUT3 (/ISO) Q9Z2B9 (/ISO)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
9 A0A0G2KD98 (/IDA) A0A0G2KZL6 (/IDA) A0A0G2L8W3 (/IDA) A2A121 (/IDA) A2A123 (/IDA) A2A124 (/IDA) A2A125 (/IDA) B5DE25 (/IDA) F1R686 (/IDA)
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
9 A2ASS6 (/IDA) D1YSG0 (/IDA) G4SLH0 (/IDA) L0MN91 (/IDA) L0MPZ1 (/IDA) O76281 (/IDA) Q7KQP6 (/IDA) Q8WZ42 (/IDA) X2JD89 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
8 A2ASS6 (/IDA) D1YSG0 (/IDA) L0MN91 (/IDA) L0MPZ1 (/IDA) O76281 (/IDA) Q7KQP6 (/IDA) Q8WZ42 (/IDA) X2JD89 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 O43293 (/ISS) Q5ZM34 (/ISS) Q8BG48 (/ISS) Q8BW96 (/ISS) Q91XS8 (/ISS) Q9WUT3 (/ISS) Q9Z2B9 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 P13234 (/TAS) P51812 (/TAS) Q15349 (/TAS) Q15418 (/TAS) Q16566 (/TAS) Q9UK32 (/TAS) Q9WUT3 (/TAS)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
7 A2ASS6 (/IDA) D1YSG0 (/IDA) L0MN91 (/IDA) L0MPZ1 (/IDA) O76281 (/IDA) Q7KQP6 (/IDA) X2JD89 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 Q6PDN3 (/ISO) Q80YE7 (/ISO) Q8BW96 (/ISO) Q8VCR8 (/ISO) Q8VDF3 (/ISO) Q9WUT3 (/ISO)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
6 A2ASS6 (/IDA) G4SLH0 (/IDA) H2FLH2 (/IDA) H2FLH3 (/IDA) Q21360 (/IDA) Q23551 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 O08605 (/ISO) P08414 (/ISO) Q91YA2 (/ISO) Q9WUT3 (/ISO) Q9Z2B9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A4V110 (/ISS) Q0KIF7 (/ISS) Q32MK0 (/ISS) Q7JMV3 (/ISS) Q8IGW6 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q15746 (/IDA) Q16566 (/IDA) Q86YV6 (/IDA) Q8WZ42 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 A2ASS6 (/ISO) P08414 (/ISO) Q5SUV5 (/ISO) Q6PDN3 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P11801 (/IDA) Q15349 (/IDA) Q16566 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q32MK0 (/ISS) Q8BW96 (/ISS) Q8VDF3 (/ISS)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
2 Q16566 (/IDA) Q9UK32 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
2 P08414 (/ISO) Q7TPS0 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O43293 (/TAS) Q15349 (/TAS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 Q9VGI4 (/IDA) Q9VGI5 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q9HBH9 (/IDA) Q9UK32 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q7TPS0 (/ISO) Q8CDB0 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 A0A024R603 (/IDA) Q9UIK4 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 Q9VGI4 (/IDA) Q9VGI5 (/IDA)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
2 P18653 (/IDA) Q9WUT3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P18653 (/ISO) Q9Z2B9 (/ISO)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
2 Q9VGI4 (/IDA) Q9VGI5 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 P20689 (/IDA) Q9JLM8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8I534 (/IDA) Q9LET1 (/IDA)
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
2 A2ASS6 (/IDA) Q8WZ42 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2 Q24496 (/IDA) Q9VR61 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
2 Q24496 (/IDA) Q9VR61 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 A0A024R603 (/IDA) Q9UIK4 (/IDA)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
2 Q24496 (/IDA) Q9VR61 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
1 Q8WZ42 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
1 A2ASS6 (/ISO)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
1 Q15746 (/IDA)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
1 Q6PDN3 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q8WZ42 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P27466 (/IPI)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9UK32 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q7TPS0 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q8VDF3 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q4G050 (/IC)
Muscle myosin complex GO:0005859
A filament of myosin found in a muscle cell of any type.
1 A2ASS6 (/TAS)
Striated muscle thin filament GO:0005865
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
1 Q8WZ42 (/IDA)
Striated muscle thin filament GO:0005865
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
1 A2ASS6 (/ISO)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
1 Q7PLI7 (/ISS)
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
1 O88764 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q80YE7 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O15075 (/TAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q6PDN3 (/IDA)
Calcium- and calmodulin-dependent protein kinase complex GO:0005954
An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
1 Q91VB2 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 Q9FIM9 (/IDA)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
1 Q91VB2 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 P53355 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q91XS8 (/IMP)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q80YE7 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q9HBH9 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q8CDB0 (/ISO)
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
1 O54784 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q9UEE5 (/IDA)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q9H1R3 (/IC)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 A2ASS6 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q15746 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q6PDN3 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P20689 (/IDA)
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
1 A2ASS6 (/ISO)
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
1 A2ASS6 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q8IID2 (/IDA)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
1 Q15746 (/IDA)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
1 Q6PDN3 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q7TNJ7 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P20689 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 P20689 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 P20689 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8VDF3 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 O88764 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q8IID2 (/IDA)