The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 78758: Protein-tyrosine kinase HTK98, variant

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 231 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
81 D3ZGM3 (/IPI) D3ZZK3 (/IPI) E9PT20 (/IPI) F1M0A6 (/IPI) O09127 (/IPI) O15197 (/IPI) O61460 (/IPI) P00519 (/IPI) P00520 (/IPI) P00522 (/IPI)
(71 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
39 A0A0G2K134 (/IDA) A0A0G2K6M9 (/IDA) A1A5H8 (/IDA) F1LM93 (/IDA) O61460 (/IDA) P00519 (/IDA) P00520 (/IDA) P00522 (/IDA) P06239 (/IDA) P06240 (/IDA)
(29 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
26 P00519 (/TAS) P05480 (/TAS) P06239 (/TAS) P06241 (/TAS) P07332 (/TAS) P07947 (/TAS) P07948 (/TAS) P08631 (/TAS) P09769 (/TAS) P12931 (/TAS)
(16 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
23 A0A0B4KEY9 (/ISS) A0A0B4KFU0 (/ISS) O42422 (/ISS) P00522 (/ISS) P00528 (/ISS) P06239 (/ISS) P06240 (/ISS) P08103 (/ISS) P14238 (/ISS) P16879 (/ISS)
(13 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
21 D2HP53 (/ISS) D2HRP3 (/ISS) D3ZDH4 (/ISS) D3ZZK3 (/ISS) E1BER5 (/ISS) E2R6A6 (/ISS) F1MFH7 (/ISS) F1SRW1 (/ISS) F6RGK7 (/ISS) F6TGX8 (/ISS)
(11 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
19 A0A0B4KEY9 (/NAS) A0A0B4KFU0 (/NAS) D1YSF9 (/NAS) P00522 (/NAS) P00528 (/NAS) P04412 (/NAS) P08630 (/NAS) P18106 (/NAS) P43403 (/NAS) Q0KIF4 (/NAS)
(9 more)
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
19 D1YSF9 (/ISS) D3ZZK3 (/ISS) P09759 (/ISS) P28693 (/ISS) P29323 (/ISS) P54764 (/ISS) Q07494 (/ISS) Q07496 (/ISS) Q0KIF4 (/ISS) Q59DQ4 (/ISS)
(9 more)
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
17 D3ZZK3 (/ISS) O08680 (/ISS) O13146 (/ISS) O42422 (/ISS) P29318 (/ISS) P29319 (/ISS) P29321 (/ISS) P29322 (/ISS) P54755 (/ISS) P54756 (/ISS)
(7 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
16 P00519 (/EXP) P00523 (/EXP) P06239 (/EXP) P06240 (/EXP) P06241 (/EXP) P07947 (/EXP) P07948 (/EXP) P08631 (/EXP) P09769 (/EXP) P12931 (/EXP)
(6 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
16 F1N9Y5 (/IMP) G5ECJ6 (/IMP) P00519 (/IMP) P00520 (/IMP) P00522 (/IMP) P05480 (/IMP) P06239 (/IMP) P06240 (/IMP) P06241 (/IMP) P08630 (/IMP)
(6 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
15 P00519 (/IDA) P00520 (/IDA) P05480 (/IDA) P12931 (/IDA) P16879 (/IDA) P21709 (/IDA) P25911 (/IDA) P39688 (/IDA) P43404 (/IDA) P43405 (/IDA)
(5 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
14 P00520 (/ISO) P05480 (/ISO) P06240 (/ISO) P08103 (/ISO) P14234 (/ISO) P16879 (/ISO) P25911 (/ISO) P35991 (/ISO) P39688 (/ISO) P43404 (/ISO)
(4 more)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
14 P07947 (/TAS) P07948 (/TAS) P09769 (/TAS) P12931 (/TAS) P42680 (/TAS) P42681 (/TAS) P42684 (/TAS) P42685 (/TAS) P43403 (/TAS) P43405 (/TAS)
(4 more)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
12 P00519 (/IDA) P00522 (/IDA) P07332 (/IDA) P09769 (/IDA) P14234 (/IDA) P16591 (/IDA) P42680 (/IDA) P43405 (/IDA) P48025 (/IDA) P51451 (/IDA)
(2 more)
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
11 D2HRP3 (/ISS) D3ZZK3 (/ISS) E1BER5 (/ISS) F6RGK7 (/ISS) F6TGX8 (/ISS) F6WF88 (/ISS) F6XVY7 (/ISS) F7AJ26 (/ISS) G7N911 (/ISS) Q03137 (/ISS)
(1 more)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
10 D3ZGM3 (/IPI) E9PT20 (/IPI) F1M0A6 (/IPI) P06239 (/IPI) P09760 (/IPI) P14234 (/IPI) P21709 (/IPI) P48025 (/IPI) Q2PYT4 (/IPI) Q9WUD9 (/IPI)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
9 P00520 (/ISO) P14234 (/ISO) P16277 (/ISO) P16879 (/ISO) P24604 (/ISO) P48025 (/ISO) P70451 (/ISO) P97504 (/ISO) Q03526 (/ISO)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
8 P03949 (/ISS) P09760 (/ISS) P14238 (/ISS) P16879 (/ISS) P70451 (/ISS) Q00655 (/ISS) Q03526 (/ISS) Q64725 (/ISS)
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
8 O13147 (/ISS) P29318 (/ISS) P54754 (/ISS) P54756 (/ISS) P54761 (/ISS) Q07498 (/ISS) Q60629 (/ISS) Q91735 (/ISS)
Phosphotyrosine binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
7 P00519 (/IPI) P06239 (/IPI) P07947 (/IPI) P08631 (/IPI) P09769 (/IPI) P42684 (/IPI) P43405 (/IPI)
Phosphotyrosine binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
7 P00520 (/ISO) P06240 (/ISO) P08103 (/ISO) P14234 (/ISO) P48025 (/ISO) Q04736 (/ISO) Q4JIM5 (/ISO)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
7 P06239 (/IPI) P06241 (/IPI) P21860 (/IPI) P41240 (/IPI) P54763 (/IPI) Q03137 (/IPI) Q06187 (/IPI)
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
6 O61460 (/IDA) P29319 (/IDA) P54753 (/IDA) P54757 (/IDA) P54760 (/IDA) P54763 (/IDA)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
6 P00528 (/IPI) P12931 (/IPI) P54763 (/IPI) Q07014 (/IPI) Q62844 (/IPI) Q9WUD9 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
6 P07947 (/IPI) P07948 (/IPI) P12931 (/IPI) Q07014 (/IPI) Q62844 (/IPI) Q9WUD9 (/IPI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
5 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) P05480 (/IMP) Q2PYT4 (/IMP)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
5 P00520 (/ISO) P05480 (/ISO) P48025 (/ISO) Q03137 (/ISO) Q60750 (/ISO)
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
5 P21709 (/IDA) P54762 (/IDA) P54763 (/IDA) Q03137 (/IDA) Q5JZY3 (/IDA)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
5 P06239 (/TAS) P12931 (/TAS) P41240 (/TAS) Q07014 (/TAS) Q9WUD9 (/TAS)
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P25911 (/IPI) Q07014 (/IPI) Q62844 (/IPI) Q8CBF3 (/IPI) Q9WUD9 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 P06240 (/ISO) P35991 (/ISO) P39688 (/ISO) P41241 (/ISO) Q61526 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
5 P07947 (/IPI) P07948 (/IPI) P12931 (/IPI) P39688 (/IPI) Q9WUD9 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
4 P00519 (/IDA) P00520 (/IDA) P42684 (/IDA) Q4JIM5 (/IDA)
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
4 O09127 (/IDA) P29320 (/IDA) Q60629 (/IDA) Q61772 (/IDA)
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
4 P29323 (/TAS) P54754 (/TAS) P54763 (/TAS) Q8CBF3 (/TAS)
Epidermal growth factor-activated receptor activity GO:0005006
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
4 B5BM27 (/ISS) B5BM28 (/ISS) P04412 (/ISS) P24348 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 P00519 (/IDA) P00520 (/IDA) P43404 (/IDA) P48025 (/IDA)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
4 P00519 (/IPI) P06239 (/IPI) P12931 (/IPI) Q9WUD9 (/IPI)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
4 P00519 (/IDA) P00520 (/IDA) P42684 (/IDA) Q4JIM5 (/IDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
4 P21860 (/IPI) Q07014 (/IPI) Q64725 (/IPI) Q9WUD9 (/IPI)
Immunoglobulin receptor binding GO:0034987
Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.
4 P09769 (/ISS) P14238 (/ISS) P16879 (/ISS) Q6P6U0 (/ISS)
CD4 receptor binding GO:0042609
Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
4 P06239 (/IPI) P06240 (/IPI) Q62844 (/IPI) W5U6C9 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
4 P00520 (/IPI) P05480 (/IPI) P06241 (/IPI) P12931 (/IPI)
Delta-catenin binding GO:0070097
Interacting selectively and non-covalently with the delta subunit of the catenin complex.
4 D3ZGM3 (/IDA) E9PT20 (/IDA) F1M0A6 (/IDA) Q2PYT4 (/IDA)
Glycoprotein binding GO:0001948
Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.
3 P06239 (/IPI) P06241 (/IPI) Q62844 (/IPI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 P12931 (/TAS) P16879 (/TAS) P42684 (/TAS)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
3 P54761 (/ISS) Q03145 (/ISS) Q1KL86 (/ISS)
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
3 Q60750 (/ISO) Q8BYG9 (/ISO) Q8CBF3 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
3 P00520 (/ISO) P05480 (/ISO) P06240 (/ISO)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
3 P54754 (/IDA) P54763 (/IDA) Q8CBF3 (/IDA)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
3 O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
3 P05480 (/ISO) P25911 (/ISO) Q04736 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
3 P00523 (/IPI) P06239 (/IPI) P32577 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
3 O61460 (/IPI) P00520 (/IPI) P05480 (/IPI)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
3 P00523 (/ISS) P05480 (/ISS) Q9WUD9 (/ISS)
Neuregulin binding GO:0038132
Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.
3 Q5RB22 (/ISS) Q61526 (/ISS) Q62799 (/ISS)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
3 P00519 (/IPI) P06239 (/IPI) P12931 (/IPI)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
3 P00520 (/ISO) P05480 (/ISO) P06240 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
3 P05480 (/ISO) P25911 (/ISO) Q04736 (/ISO)
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
3 P06239 (/TAS) P06241 (/TAS) P21860 (/TAS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 P00520 (/ISO) Q4JIM5 (/ISO)
Phosphotyrosine binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Glycoprotein binding GO:0001948
Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.
2 P06240 (/ISO) P39688 (/ISO)
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
2 P00519 (/TAS) P42684 (/TAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
2 P29317 (/IDA) P54760 (/IDA)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
2 P54761 (/ISO) Q03145 (/ISO)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
2 P06241 (/NAS) Q24145 (/NAS)
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
2 P54754 (/ISO) P54761 (/ISO)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
2 P00519 (/IPI) Q9WUD9 (/IPI)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2 P06241 (/TAS) P21860 (/TAS)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
2 P09760 (/ISS) P70451 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P41241 (/TAS) Q06187 (/TAS)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
2 P09760 (/ISS) P70451 (/ISS)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 F1NHC7 (/IDA) P00520 (/IDA)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
2 P00519 (/IPI) P25911 (/IPI)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
2 A6QR62 (/IPI) P21860 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P06240 (/ISO) Q60750 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
2 P00520 (/ISO) Q4JIM5 (/ISO)
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q01621 (/IDA) Q07014 (/IDA)
Immunoglobulin receptor binding GO:0034987
Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.
2 P07332 (/IDA) P14234 (/IDA)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
2 P14238 (/ISS) P16879 (/ISS)
T cell receptor binding GO:0042608
Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
2 P06239 (/IPI) W5U6C9 (/IPI)
CD8 receptor binding GO:0042610
Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.
2 P06239 (/IPI) Q62844 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
2 P12931 (/IDA) P29317 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
2 P05480 (/ISO) Q03145 (/ISO)
Chemorepellent activity GO:0045499
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.
2 P54759 (/ISS) Q15375 (/ISS)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
2 D3ZZK3 (/IDA) P54759 (/IDA)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
2 P05480 (/ISO) P39688 (/ISO)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 P09760 (/IPI) Q9WUD9 (/IPI)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
2 P12931 (/IPI) Q07014 (/IPI)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
2 P00519 (/IPI) P32577 (/IPI)
Growth factor receptor binding GO:0070851
Interacting selectively and non-covalently with a growth factor receptor.
2 P06241 (/IPI) P12931 (/IPI)
Growth factor receptor binding GO:0070851
Interacting selectively and non-covalently with a growth factor receptor.
2 P05480 (/ISO) P39688 (/ISO)
Connexin binding GO:0071253
Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions.
2 P00523 (/IPI) P05480 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
2 P05480 (/IPI) P12931 (/IPI)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
1 P42681 (/IDA)
RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.
1 P42682 (/ISO)
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P42681 (/IDA)
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P42682 (/ISO)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P42681 (/IDA)
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
1 P42682 (/ISO)
G-protein coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G-protein coupled receptor.
1 P39688 (/IPI)
Phosphotyrosine binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 P14234 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P00519 (/NAS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 P09760 (/IPI)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
1 Q01621 (/IPI)
Nicotinate-nucleotide adenylyltransferase activity GO:0004515
Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.
1 P00519 (/TAS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P43405 (/NAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P43405 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P48025 (/ISO)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P00522 (/ISA)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 Q62799 (/TAS)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
1 F1N9Y5 (/IMP)
Signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716
Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 P48025 (/IDA)
Signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716
Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 O61460 (/ISS)
Signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716
Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 P07948 (/TAS)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
1 P06239 (/IDA)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
1 P06240 (/ISO)
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 P39688 (/IGI)
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 P51813 (/TAS)
Receptor activity GO:0004872
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
1 P54763 (/IDA)
Receptor activity GO:0004872
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
1 O15197 (/TAS)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 A6QR62 (/IDA)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 P21860 (/ISS)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 P04412 (/TAS)
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
1 P54759 (/NAS)
Ephrin receptor activity GO:0005003
Combining with an ephrin to initiate a change in cell activity.
1 O15197 (/TAS)
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
1 Q03137 (/IMP)
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
1 P29319 (/ISO)
Transmembrane-ephrin receptor activity GO:0005005
Combining with a transmembrane ephrin to initiate a change in cell activity.
1 P54756 (/NAS)
Epidermal growth factor-activated receptor activity GO:0005006
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P04412 (/TAS)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
1 P12931 (/TAS)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 P00520 (/ISO)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P05480 (/ISO)
Erythropoietin receptor binding GO:0005128
Interacting selectively and non-covalently with the erythropoietin receptor.
1 P25911 (/TAS)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 P16591 (/IDA)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 F1LM93 (/IPI)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 P70451 (/ISO)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
1 Q9WUD9 (/IPI)
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
1 Q07014 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q07014 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P43405 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P48025 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P12931 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P00520 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P43403 (/NAS)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P18106 (/ISM)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P42680 (/NAS)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 Q06187 (/IDA)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 P35991 (/ISO)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 P16879 (/IDA)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P41240 (/TAS)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
1 Q61772 (/IMP)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
1 P09760 (/IPI)
Protein phosphatase 1 binding GO:0008157
Interacting selectively and non-covalently with the enzyme protein phosphatase 1.
1 P70451 (/IPI)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
1 P16591 (/IDA)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
1 P70451 (/ISO)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 P39688 (/IDA)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
1 Q05876 (/ISS)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P05480 (/IMP)
Transferase activity GO:0016740
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
1 P41241 (/TAS)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 P00520 (/ISO)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 P09760 (/IPI)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 Q61526 (/ISO)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 P21860 (/ISS)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P12931 (/IPI)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P05480 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P14234 (/IDA)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 P48025 (/IPI)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P06240 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q64725 (/IMP)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 P00519 (/IPI)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
1 P00520 (/ISO)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 P12931 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 P05480 (/ISO)
Protein tyrosine kinase activator activity GO:0030296
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
1 P21860 (/IDA)
Protein tyrosine kinase activator activity GO:0030296
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
1 Q61526 (/ISO)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 Q9WUD9 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q61526 (/ISO)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
1 P41240 (/IPI)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
1 P41241 (/ISO)
Immunoglobulin receptor binding GO:0034987
Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.
1 P16879 (/ISO)
Fc-gamma receptor I complex binding GO:0034988
Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
1 P09769 (/IDA)
Fc-gamma receptor I complex binding GO:0034988
Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
1 P14234 (/ISO)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 P07332 (/IDA)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 P16879 (/ISO)
Toll-like receptor binding GO:0035325
Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
1 P48025 (/IPI)
Neuregulin receptor activity GO:0038131
Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 Q62799 (/IMP)
Neuregulin binding GO:0038132
Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.
1 P21860 (/IDA)
Neuregulin binding GO:0038132
Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.
1 Q62799 (/IMP)
Neuregulin binding GO:0038132
Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.
1 Q61526 (/ISO)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
1 P48025 (/IDA)
T cell receptor binding GO:0042608
Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
1 Q62844 (/IDA)
T cell receptor binding GO:0042608
Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
1 P06240 (/ISO)
CD4 receptor binding GO:0042609
Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
1 P06240 (/ISO)
CD8 receptor binding GO:0042610
Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.
1 P06240 (/ISO)
PH domain binding GO:0042731
Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
1 P54764 (/IPI)
PH domain binding GO:0042731
Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
1 Q03137 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P21860 (/NAS)
Gamma-tubulin binding GO:0043015
Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.
1 Q07014 (/IDA)
Glycosphingolipid binding GO:0043208
Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.
1 Q07014 (/IPI)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 Q62844 (/IDA)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 P06239 (/IPI)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 P06240 (/ISO)
Gamma-catenin binding GO:0045295
Interacting selectively and non-covalently with the gamma subunit of the catenin complex.
1 P09760 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P09760 (/IPI)
Chemorepellent activity GO:0045499
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.
1 Q61772 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P21860 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P21860 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q61526 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P00520 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P42684 (/TAS)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
1 P00519 (/IPI)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
1 P00520 (/ISO)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 P06239 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 P06240 (/ISO)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
1 P05480 (/ISO)
Peptide hormone receptor binding GO:0051428
Interacting selectively and non-covalently with a receptor for peptide hormones.
1 Q62844 (/IPI)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
1 P00519 (/IDA)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
1 P00520 (/ISO)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
1 P00520 (/ISS)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 P05480 (/ISO)
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
1 P54764 (/IDA)
DH domain binding GO:0097161
Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
1 Q03137 (/ISO)
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
1 P06241 (/IPI)
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
1 P39688 (/ISO)
Protein antigen binding GO:1990405
Interacting selectively and non-covalently with a protein antigen.
1 P06240 (/IPI)

There are 1370 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
37 A0A0G2K134 (/IDA) A0A0G2K6M9 (/IDA) A1A5H8 (/IDA) D3ZGM3 (/IDA) E9PT20 (/IDA) F1LM93 (/IDA) F1M0A6 (/IDA) O09127 (/IDA) P00519 (/IDA) P00522 (/IDA)
(27 more)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
32 D2HP53 (/ISS) D2HRP3 (/ISS) D3ZDH4 (/ISS) D3ZZK3 (/ISS) E1BER5 (/ISS) E2R6A6 (/ISS) F1MFH7 (/ISS) F1SRW1 (/ISS) F6RGK7 (/ISS) F6TGX8 (/ISS)
(22 more)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
31 O61460 (/IDA) P00519 (/IDA) P00520 (/IDA) P00522 (/IDA) P05480 (/IDA) P06240 (/IDA) P07332 (/IDA) P07948 (/IDA) P08630 (/IDA) P09769 (/IDA)
(21 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
31 D1YSF9 (/ISS) D2HRP3 (/ISS) D3ZZK3 (/ISS) E1BER5 (/ISS) F6RGK7 (/ISS) F6TGX8 (/ISS) F6WF88 (/ISS) F6XVY7 (/ISS) F7AJ26 (/ISS) G7N911 (/ISS)
(21 more)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
28 O15197 (/TAS) P00523 (/TAS) P05480 (/TAS) P06241 (/TAS) P07947 (/TAS) P07948 (/TAS) P09324 (/TAS) P12931 (/TAS) P21709 (/TAS) P28693 (/TAS)
(18 more)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
27 D1YSF9 (/ISS) O08680 (/ISS) O13146 (/ISS) O13147 (/ISS) O42422 (/ISS) P09759 (/ISS) P28693 (/ISS) P29318 (/ISS) P29321 (/ISS) P29322 (/ISS)
(17 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
20 A0A0B4KEY9 (/NAS) A0A0B4KFU0 (/NAS) D1YSF9 (/NAS) P00522 (/NAS) P00528 (/NAS) P04412 (/NAS) P06241 (/NAS) P08630 (/NAS) P18106 (/NAS) P43403 (/NAS)
(10 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
17 O13147 (/ISS) P09759 (/ISS) P28693 (/ISS) P29321 (/ISS) P29322 (/ISS) P29323 (/ISS) P54753 (/ISS) P54755 (/ISS) P54756 (/ISS) P54757 (/ISS)
(7 more)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
17 D3ZZK3 (/ISS) O08680 (/ISS) O13146 (/ISS) O13147 (/ISS) P29318 (/ISS) P29319 (/ISS) P54754 (/ISS) P54755 (/ISS) P54756 (/ISS) P54757 (/ISS)
(7 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
15 F1NHC7 (/IDA) P05480 (/IDA) P06239 (/IDA) P06240 (/IDA) P07948 (/IDA) P32577 (/IDA) P35991 (/IDA) P42681 (/IDA) P43403 (/IDA) P43404 (/IDA)
(5 more)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
15 P00520 (/ISO) P05480 (/ISO) P06240 (/ISO) P08103 (/ISO) P14234 (/ISO) P16879 (/ISO) P24604 (/ISO) P25911 (/ISO) P35991 (/ISO) P39688 (/ISO)
(5 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
14 P06241 (/TAS) P07332 (/TAS) P07948 (/TAS) P08631 (/TAS) P09769 (/TAS) P16591 (/TAS) P41240 (/TAS) P41241 (/TAS) P42679 (/TAS) P42680 (/TAS)
(4 more)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
14 F1N9Y5 (/IMP) P00519 (/IMP) P00522 (/IMP) P06239 (/IMP) P06241 (/IMP) P08630 (/IMP) P08631 (/IMP) P12931 (/IMP) P39688 (/IMP) P43403 (/IMP)
(4 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
14 P00520 (/ISO) P05480 (/ISO) P08103 (/ISO) P14234 (/ISO) P16879 (/ISO) P25911 (/ISO) P42682 (/ISO) P54754 (/ISO) P54761 (/ISO) P70451 (/ISO)
(4 more)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
14 O09127 (/IDA) P29317 (/IDA) P29319 (/IDA) P29320 (/IDA) P54753 (/IDA) P54757 (/IDA) P54760 (/IDA) P54762 (/IDA) P54763 (/IDA) Q03145 (/IDA)
(4 more)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
14 F1N9Y5 (/ISS) O42422 (/ISS) P07948 (/ISS) P09759 (/ISS) P43405 (/ISS) P54759 (/ISS) Q00655 (/ISS) Q07014 (/ISS) Q07494 (/ISS) Q61772 (/ISS)
(4 more)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
12 O13147 (/ISS) P09759 (/ISS) P28693 (/ISS) P29323 (/ISS) P54753 (/ISS) P54762 (/ISS) Q07494 (/ISS) Q07498 (/ISS) Q90344 (/ISS) Q91571 (/ISS)
(2 more)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
12 O13147 (/ISS) P09759 (/ISS) P28693 (/ISS) P29323 (/ISS) P54753 (/ISS) P54762 (/ISS) Q07494 (/ISS) Q07498 (/ISS) Q90344 (/ISS) Q91571 (/ISS)
(2 more)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
12 O13147 (/ISS) P09759 (/ISS) P28693 (/ISS) P29323 (/ISS) P54753 (/ISS) P54762 (/ISS) Q07494 (/ISS) Q07498 (/ISS) Q90344 (/ISS) Q91571 (/ISS)
(2 more)
Positive regulation of Rho guanyl-nucleotide exchange factor activity GO:2001108
Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
11 D2HRP3 (/ISS) D3ZZK3 (/ISS) E1BER5 (/ISS) F6RGK7 (/ISS) F6TGX8 (/ISS) F6WF88 (/ISS) F6XVY7 (/ISS) F7AJ26 (/ISS) G7N911 (/ISS) Q03137 (/ISS)
(1 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
10 O09127 (/IMP) O61460 (/IMP) P00522 (/IMP) P00528 (/IMP) P18106 (/IMP) P54754 (/IMP) P54763 (/IMP) Q03137 (/IMP) Q8CBF3 (/IMP) Q9V9J3 (/IMP)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
10 P07948 (/TAS) P24604 (/TAS) P35991 (/TAS) P42680 (/TAS) P43405 (/TAS) Q03526 (/TAS) Q06187 (/TAS) Q08881 (/TAS) Q5S255 (/TAS) Q64725 (/TAS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
9 O08680 (/ISS) O13146 (/ISS) O13147 (/ISS) P29318 (/ISS) P29320 (/ISS) Q03145 (/ISS) Q07498 (/ISS) Q1KL86 (/ISS) Q91735 (/ISS)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
9 P00519 (/TAS) P06241 (/TAS) P07947 (/TAS) P07948 (/TAS) P08631 (/TAS) P09769 (/TAS) P12931 (/TAS) P43405 (/TAS) Q64725 (/TAS)
Regulation of phagocytosis GO:0050764
Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
9 F1N9Y5 (/ISS) P08103 (/ISS) P09769 (/ISS) P43405 (/ISS) P50545 (/ISS) Q00655 (/ISS) Q64725 (/ISS) Q6P6U0 (/ISS) Q95M30 (/ISS)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
9 D2HP53 (/ISS) D3ZDH4 (/ISS) E2R6A6 (/ISS) F1MFH7 (/ISS) F1SRW1 (/ISS) F6WYP6 (/ISS) F7APP4 (/ISS) F7I7A7 (/ISS) P21709 (/ISS)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
8 P08103 (/ISS) P09769 (/ISS) P14238 (/ISS) P16879 (/ISS) P50545 (/ISS) Q05876 (/ISS) Q6P6U0 (/ISS) Q95M30 (/ISS)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
8 D1YSF9 (/IMP) P00522 (/IMP) P04412 (/IMP) Q0KIF4 (/IMP) Q24145 (/IMP) Q59DQ4 (/IMP) Q8IMC2 (/IMP) Q9V4E5 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
8 P05480 (/IMP) P29317 (/IMP) P29319 (/IMP) P54754 (/IMP) Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9V9J3 (/IMP) Q9VGK8 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
8 D3ZGM3 (/IEP) E9PT20 (/IEP) F1M0A6 (/IEP) Q07014 (/IEP) Q2PYT4 (/IEP) Q62799 (/IEP) Q62844 (/IEP) Q9WUD9 (/IEP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
7 P09759 (/ISS) P28693 (/ISS) P29323 (/ISS) P54753 (/ISS) P54760 (/ISS) Q8CBF3 (/ISS) Q90344 (/ISS)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
7 A0A0R4IBB3 (/IGI) A0A0R4IUU0 (/IGI) E9QFU7 (/IGI) F1QFN4 (/IGI) M9MM92 (/IGI) Q503P3 (/IGI) Q910A2 (/IGI)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
7 A0A0R4IBB3 (/IMP) A0A0R4IUU0 (/IMP) E9QFU7 (/IMP) F1QFN4 (/IMP) M9MM92 (/IMP) Q503P3 (/IMP) Q910A2 (/IMP)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
7 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) P54754 (/IMP) P54763 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
7 O13147 (/ISS) P28693 (/ISS) P29323 (/ISS) P54753 (/ISS) Q07498 (/ISS) Q90344 (/ISS) Q91735 (/ISS)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
7 D1YSF9 (/IMP) P04412 (/IMP) Q0KIF4 (/IMP) Q59DQ4 (/IMP) Q61526 (/IMP) Q8IMC2 (/IMP) Q9V4E5 (/IMP)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
7 O13064 (/ISS) P07948 (/ISS) P08103 (/ISS) P50545 (/ISS) Q07014 (/ISS) Q60750 (/ISS) Q95M30 (/ISS)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
7 O13147 (/ISS) O42422 (/ISS) P54754 (/ISS) P54759 (/ISS) Q07498 (/ISS) Q15375 (/ISS) Q91735 (/ISS)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
7 O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29319 (/ISS) P54755 (/ISS) P54756 (/ISS) P54757 (/ISS)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
7 O13147 (/ISS) P09760 (/ISS) P16591 (/ISS) P54754 (/ISS) Q07498 (/ISS) Q60750 (/ISS) Q91735 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
7 P06241 (/TAS) P12931 (/TAS) P16591 (/TAS) P41241 (/TAS) P42680 (/TAS) P51451 (/TAS) Q06187 (/TAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
7 A0A0R4IBB3 (/IGI) A0A0R4IUU0 (/IGI) E9QFU7 (/IGI) F1QFN4 (/IGI) M9MM92 (/IGI) Q503P3 (/IGI) Q910A2 (/IGI)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
7 A0A0R4IBB3 (/IMP) A0A0R4IUU0 (/IMP) E9QFU7 (/IMP) F1QFN4 (/IMP) M9MM92 (/IMP) Q503P3 (/IMP) Q910A2 (/IMP)
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
7 P06239 (/ISS) P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
6 P42681 (/ISS) P43405 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q08881 (/ISS) Q64725 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 F1N9Y5 (/IMP) P39688 (/IMP) Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9V9J3 (/IMP) Q9VGK8 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 A0A0B4KEY9 (/ISS) A0A0B4KFU0 (/ISS) P43405 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
6 F1N9Y5 (/ISS) P09769 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS) Q6P6U0 (/ISS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
6 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) P00522 (/IMP) P00528 (/IMP) Q2PYT4 (/IMP)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
6 P07948 (/IMP) P25911 (/IMP) P41241 (/IMP) Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9VGK8 (/IMP)
Schwann cell differentiation GO:0014037
The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
6 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP) Q61526 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
6 D1YSF9 (/IMP) P00528 (/IMP) Q0KIF4 (/IMP) Q59DQ4 (/IMP) Q8IMC2 (/IMP) Q9V4E5 (/IMP)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
6 P06239 (/TAS) P06241 (/TAS) P07948 (/TAS) P12931 (/TAS) P43405 (/TAS) P48025 (/TAS)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
6 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) F1RDG9 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
6 P06239 (/TAS) P06241 (/TAS) P07947 (/TAS) P07948 (/TAS) P12931 (/TAS) P41240 (/TAS)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
6 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP) Q6EWH2 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
6 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) P00520 (/IMP) P54759 (/IMP) Q2PYT4 (/IMP)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
6 D3ZZK3 (/IDA) P21709 (/IDA) P29320 (/IDA) P54753 (/IDA) Q03137 (/IDA) Q60629 (/IDA)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
6 P29319 (/ISO) P54754 (/ISO) P54761 (/ISO) Q03145 (/ISO) Q61772 (/ISO) Q8CBF3 (/ISO)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
6 D3ZZK3 (/ISS) O13147 (/ISS) P54753 (/ISS) P54764 (/ISS) Q07498 (/ISS) Q91735 (/ISS)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
6 P09759 (/ISS) Q03145 (/ISS) Q07494 (/ISS) Q1KL86 (/ISS) Q91571 (/ISS) Q91736 (/ISS)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
6 F1N9Y5 (/ISS) P07948 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q07014 (/ISS) Q64725 (/ISS)
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
6 O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29320 (/ISS) P54764 (/ISS) Q07496 (/ISS)
Fasciculation of motor neuron axon GO:0097156
The collection of motor neuron axons into a bundle of rods, known as a fascicle.
6 D3ZZK3 (/ISS) O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29320 (/ISS) P54764 (/ISS)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
5 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP)
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
5 P06241 (/TAS) P07948 (/TAS) P12931 (/TAS) P43405 (/TAS) P48025 (/TAS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 P06240 (/ISO) P25911 (/ISO) P42682 (/ISO) P43404 (/ISO) P48025 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
5 P07948 (/TAS) P12931 (/TAS) P25911 (/TAS) P42684 (/TAS) Q08881 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
5 P05480 (/TAS) P06241 (/TAS) P12931 (/TAS) P28693 (/TAS) P39688 (/TAS)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
5 P04412 (/IMP) P08631 (/IMP) P16591 (/IMP) P21709 (/IMP) P25911 (/IMP)
Schwann cell development GO:0014044
The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
5 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
5 P09759 (/ISS) P54762 (/ISS) Q07494 (/ISS) Q91571 (/ISS) Q91736 (/ISS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
5 P09760 (/ISS) P09769 (/ISS) P70451 (/ISS) Q60750 (/ISS) Q6P6U0 (/ISS)
Cell-substrate adhesion GO:0031589
The attachment of a cell to the underlying substrate via adhesion molecules.
5 P09759 (/ISS) Q07494 (/ISS) Q8CBF3 (/ISS) Q91571 (/ISS) Q91736 (/ISS)
Melanotic encapsulation of foreign target GO:0035011
Formation of a multilayered, melanized sheath of cells around a foreign invader.
5 D1YSF9 (/IMP) Q0KIF4 (/IMP) Q59DQ4 (/IMP) Q8IMC2 (/IMP) Q9V4E5 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
5 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP) Q61772 (/IMP)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
5 P09759 (/ISS) Q07494 (/ISS) Q8CBF3 (/ISS) Q91571 (/ISS) Q91736 (/ISS)
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
5 P00528 (/IGI) Q7KSQ2 (/IGI) Q8INJ8 (/IGI) Q9V9J3 (/IGI) Q9VGK8 (/IGI)
Myelination of anterior lateral line nerve axons GO:0048914
The formation of compact myelin sheaths around the axons of the anterior lateral line nerve.
5 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP)
Myelination of posterior lateral line nerve axons GO:0048932
The formation of compact myelin sheaths around the axons of the posterior lateral line nerve.
5 E9QC99 (/IMP) F1QP50 (/IMP) F1R5S1 (/IMP) Q5EBY4 (/IMP) Q5G254 (/IMP)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
5 P06240 (/IDA) P25911 (/IDA) P42680 (/IDA) P48025 (/IDA) P51451 (/IDA)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
5 P06239 (/TAS) P06241 (/TAS) P07947 (/TAS) P07948 (/TAS) P12931 (/TAS)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
5 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) P00520 (/IMP) Q2PYT4 (/IMP)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
5 P08103 (/ISS) P14238 (/ISS) P16879 (/ISS) P50545 (/ISS) Q95M30 (/ISS)
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
4 B5BM27 (/IMP) B5BM28 (/IMP) G5ECJ6 (/IMP) P24348 (/IMP)
Macrophage activation involved in immune response GO:0002281
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Neutrophil activation involved in immune response GO:0002283
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Leukocyte activation involved in immune response GO:0002366
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Histamine secretion by mast cell GO:0002553
The regulated release of histamine by a mast cell or group of mast cells.
4 A0A0G2K134 (/IMP) A0A0G2K6M9 (/IMP) Q07014 (/IMP) Q5S255 (/IMP)
Serotonin secretion by platelet GO:0002554
The regulated release of serotonin by a platelet or group of platelets.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
4 F1N9Y5 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
4 P06240 (/IDA) P21709 (/IDA) P39688 (/IDA) P48025 (/IDA)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P09769 (/IMP) P12931 (/IMP) P14234 (/IMP) P48025 (/IMP)
Germarium-derived egg chamber formation GO:0007293
Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
4 P00528 (/IMP) Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9VGK8 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
4 P00528 (/TAS) P08630 (/TAS) Q24145 (/TAS) Q9V9J3 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
4 P54754 (/IDA) P54763 (/IDA) Q60629 (/IDA) Q8CBF3 (/IDA)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
4 P08631 (/TAS) P42679 (/TAS) P51813 (/TAS) Q06187 (/TAS)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
4 D3ZGM3 (/IEP) E9PT20 (/IEP) F1M0A6 (/IEP) Q2PYT4 (/IEP)
Glial cell migration GO:0008347
The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
4 D3ZZK3 (/IMP) E9QC99 (/IMP) F1QP50 (/IMP) Q5G254 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
4 P00522 (/IMP) P07332 (/IMP) P08631 (/IMP) P14234 (/IMP)
Regulation of platelet activation GO:0010543
Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of lamellipodium assembly GO:0010591
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
4 P09760 (/ISS) P70451 (/ISS) Q03145 (/ISS) Q1KL86 (/ISS)
Regulation of epithelial to mesenchymal transition GO:0010717
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
4 O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29320 (/ISS)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
4 P07332 (/IMP) P07948 (/IMP) P29320 (/IMP) P42684 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
4 P16879 (/ISO) P25911 (/ISO) P29319 (/ISO) Q4JIM5 (/ISO)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
4 O42422 (/ISS) P29323 (/ISS) Q15375 (/ISS) Q61772 (/ISS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
4 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
4 P14238 (/ISS) P16879 (/ISS) P29321 (/ISS) P29322 (/ISS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
4 P14234 (/IMP) P16591 (/IMP) P21709 (/IMP) P25911 (/IMP)
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
4 A0A0R4ITT4 (/IGI) F1RCL1 (/IGI) O13148 (/IGI) Q90ZN9 (/IGI)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
4 F1N9Y5 (/ISS) P48025 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of superoxide anion generation GO:0032928
Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
4 P29321 (/ISS) P29322 (/ISS) Q03145 (/ISS) Q1KL86 (/ISS)
Positive regulation of cell adhesion mediated by integrin GO:0033630
Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
4 P00520 (/IDA) P05480 (/IDA) P21709 (/IDA) P54753 (/IDA)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
4 D3ZGM3 (/IEP) E9PT20 (/IEP) F1M0A6 (/IEP) Q2PYT4 (/IEP)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
4 A0A0G2K134 (/IMP) A0A0G2K6M9 (/IMP) P70451 (/IMP) Q5S255 (/IMP)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
4 D3ZGM3 (/IDA) E9PT20 (/IDA) F1M0A6 (/IDA) Q2PYT4 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
4 P03949 (/IMP) P04412 (/IMP) P08631 (/IMP) P12931 (/IMP)
Regulation of mast cell degranulation GO:0043304
Any process that modulates the frequency, rate, or extent of mast cell degranulation.
4 P07948 (/ISS) P14238 (/ISS) P16879 (/ISS) Q07014 (/ISS)
Regulation of neutrophil degranulation GO:0043313
Any process that modulates the frequency, rate, or extent of neutrophil degranulation.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
4 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
4 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Negative regulation of collateral sprouting of intact axon in response to injury GO:0048685
Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon.
4 A0A0R4ITT4 (/IGI) F1RCL1 (/IGI) O13148 (/IGI) Q90ZN9 (/IGI)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
4 P00519 (/IDA) P25911 (/IDA) P42680 (/IDA) Q04736 (/IDA)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
4 P06239 (/TAS) P41240 (/TAS) P43403 (/TAS) Q08881 (/TAS)
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
4 O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29319 (/ISS)
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
4 O08680 (/ISS) O13146 (/ISS) P29318 (/ISS) P29319 (/ISS)
Cellular response to molecule of fungal origin GO:0071226
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
4 D3ZGM3 (/IEP) E9PT20 (/IEP) F1M0A6 (/IEP) Q2PYT4 (/IEP)
Response to epinephrine GO:0071871
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
4 D3ZGM3 (/IEP) E9PT20 (/IEP) F1M0A6 (/IEP) Q2PYT4 (/IEP)
Regulation of arachidonic acid secretion GO:0090237
Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
4 F1N9Y5 (/ISS) P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
4 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP)
Positive regulation of hydrogen peroxide-mediated programmed cell death GO:1901300
Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
4 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP)
Positive regulation of extracellular matrix organization GO:1903055
Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.
4 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP)
Glomerular visceral epithelial cell apoptotic process GO:1903210
Any apoptotic process in a glomerular visceral epithelial cell.
4 D3ZGM3 (/IMP) E9PT20 (/IMP) F1M0A6 (/IMP) Q2PYT4 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
3 P54754 (/IMP) P54761 (/IMP) P54763 (/IMP)
Positive regulation of type III hypersensitivity GO:0001805
Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.
3 A0A0G2K134 (/IMP) A0A0G2K6M9 (/IMP) Q5S255 (/IMP)
Positive regulation of type I hypersensitivity GO:0001812
Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.
3 A0A0G2K134 (/IMP) A0A0G2K6M9 (/IMP) Q5S255 (/IMP)
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
3 E9QC99 (/IMP) F1QP50 (/IMP) Q5G254 (/IMP)
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
3 F1N9Y5 (/IMP) P42682 (/IMP) Q03526 (/IMP)
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
3 P00520 (/IMP) P08103 (/IMP) Q4JIM5 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 P21860 (/IDA) P51813 (/IDA) P70451 (/IDA)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 B5BM27 (/ISS) B5BM28 (/ISS) P24348 (/ISS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
3 P04412 (/TAS) P12931 (/TAS) P41240 (/TAS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P05480 (/ISO) P14234 (/ISO) P24604 (/ISO)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
3 P00528 (/TAS) P08630 (/TAS) Q9V9J3 (/TAS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
3 P00522 (/IMP) P04412 (/IMP) Q9V9J3 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
3 P00528 (/IMP) P08630 (/IMP) Q9V9J3 (/IMP)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
3 P00528 (/IMP) P08630 (/IMP) Q9V9J3 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
3 P00520 (/TAS) P06241 (/TAS) P07948 (/TAS)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
3 P07332 (/TAS) P42679 (/TAS) P43405 (/TAS)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 P08103 (/ISO) P70451 (/ISO) Q60750 (/ISO)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
3 O13064 (/ISS) P07948 (/ISS) Q07014 (/ISS)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
3 G5ECJ6 (/IMP) O61460 (/IMP) P04412 (/IMP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
3 A0A0G2K134 (/IMP) A0A0G2K6M9 (/IMP) Q5S255 (/IMP)
Epithelial structure maintenance GO:0010669
A tissue homeostatic process required for the maintenance of epithelial structure.
3 Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9VGK8 (/IMP)
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
3 E9QC99 (/IMP) F1QP50 (/IMP) Q5G254 (/IMP)
Regulation of phosphatidylinositol 3-kinase signaling GO:0014066
Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
3 P06239 (/TAS) P06241 (/TAS) P21860 (/TAS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
3 Q7KSQ2 (/IGI) Q8INJ8 (/IGI) Q9VGK8 (/IGI)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
3 P54755 (/ISS) P54756 (/ISS) P54757 (/ISS)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
3 O13064 (/ISS) P07948 (/ISS) Q07014 (/ISS)
Melanocyte differentiation GO:0030318
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
3 E9QC99 (/IMP) F1QP50 (/IMP) Q5G254 (/IMP)
Male genitalia development GO:0030539
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
3 B5BM27 (/IMP) B5BM28 (/IMP) P24348 (/IMP)
Ovulation GO:0030728
The release of a mature ovum/oocyte from an ovary.
3 B5BM27 (/IMP) B5BM28 (/IMP) P24348 (/IMP)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
3 P54754 (/IDA) P54763 (/IDA) Q8CBF3 (/IDA)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
3 P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Regulation of protein autophosphorylation GO:0031952
Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.
3 O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS)
Adherens junction maintenance GO:0034334
The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
3 Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9VGK8 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
3 P12931 (/IDA) P25911 (/IDA) P48025 (/IDA)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
3 P05480 (/IDA) P39688 (/IDA) Q04736 (/IDA)
Peptidyl-tyrosine autophosphorylation GO:0038083
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.
3 P00520 (/ISO) P24604 (/ISO) Q62270 (/ISO)
ERBB2 signaling pathway GO:0038128
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
3 P12931 (/TAS) P21860 (/TAS) P42679 (/TAS)
Positive regulation of vulval development GO:0040026
Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
3 B5BM27 (/IMP) B5BM28 (/IMP) P24348 (/IMP)
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
3 A0A0G2KA94 (/IEP) B2RYC7 (/IEP) Q9EQ78 (/IEP)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
3 O13064 (/ISS) P07948 (/ISS) Q07014 (/ISS)
Positive regulation of programmed cell death GO:0043068
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
3 Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9VGK8 (/IMP)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
3 P29319 (/ISO) P54754 (/ISO) Q60750 (/ISO)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
3 P00520 (/IGI) P39688 (/IGI) Q4JIM5 (/IGI)
Regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281
Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.
3 O42422 (/ISS) P54759 (/ISS) Q15375 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
3 P09769 (/IMP) P25911 (/IMP) Q9WUD9 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
3 Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9VGK8 (/IMP)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
3 A1A5H8 (/IGI) F1RDG9 (/IGI) Q6EWH2 (/IGI)
Negative regulation of growth GO:0045926
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
3 Q7KSQ2 (/IGI) Q8INJ8 (/IGI) Q9VGK8 (/IGI)
Negative regulation of growth GO:0045926
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
3 Q7KSQ2 (/IMP) Q8INJ8 (/IMP) Q9VGK8 (/IMP)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P05480 (/TAS) P06241 (/TAS) P12931 (/TAS)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
3 A0A0R4IJK3 (/IGI) F1RCR4 (/IGI) P54761 (/IGI)
Phosphatidylinositol-mediated signaling GO:0048015
A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
3 P06239 (/TAS) P06241 (/TAS) P21860 (/TAS)
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
3 E9QC99 (/IMP) F1QP50 (/IMP) Q5G254 (/IMP)
Macrophage chemotaxis GO:0048246
The movement of a macrophage in response to an external stimulus.
3 A5WWJ6 (/IMP) Q66HZ1 (/IMP) Q8AWF1 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
3 P00528 (/IMP) P05480 (/IMP) P08630 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.
3 P00522 (/IMP) P39688 (/IMP) Q4JIM5 (/IMP)
Lateral line development GO:0048882
The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear.
3 E9QC99 (/IMP) F1QP50 (/IMP) Q5G254 (/IMP)
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
3 P06239 (/TAS) P06241 (/TAS) P08631 (/TAS)
Regulation of phagocytosis GO:0050764
Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
3 P08631 (/IMP) P14234 (/IMP) P48025 (/IMP)
Activated T cell proliferation GO:0050798
The expansion of a T cell population following activation by an antigenic stimulus.
3 O08644 (/IMP) P00520 (/IMP) P39688 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
3 P42682 (/IMP) P43404 (/IMP) Q03526 (/IMP)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
3 P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
3 P54754 (/IMP) P54763 (/IMP) Q8CBF3 (/IMP)
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
3 A1A5H8 (/IGI) F1RDG9 (/IGI) Q6EWH2 (/IGI)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
3 P54754 (/IMP) P54763 (/IMP) Q8CBF3 (/IMP)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
3 P54754 (/IMP) P54763 (/IMP) Q8CBF3 (/IMP)
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
3 F1QR66 (/IMP) F1R5F3 (/IMP) O73878 (/IMP)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 P25911 (/IMP) P29317 (/IMP) P48025 (/IMP)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 Q03145 (/ISO) Q61772 (/ISO) Q8CBF3 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 P00520 (/IMP) P05480 (/IMP) Q9WUD9 (/IMP)
Cellular response to molecule of fungal origin GO:0071226
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.
3 A0A0G2K134 (/IDA) A0A0G2K6M9 (/IDA) Q5S255 (/IDA)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
3 P07948 (/IMP) P29320 (/IMP) P42684 (/IMP)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
3 P25911 (/ISO) P29319 (/ISO) Q4JIM5 (/ISO)
Cellular response to follicle-stimulating hormone stimulus GO:0071372
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
3 O09127 (/IDA) P29319 (/IDA) Q60629 (/IDA)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
3 P43405 (/ISS) Q00655 (/ISS) Q64725 (/ISS)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
3 P05480 (/IGI) P39688 (/IGI) Q04736 (/IGI)
Regulation of podosome assembly GO:0071801
Any process that modulates the frequency, rate or extent of podosome assembly.
3 P08103 (/ISS) P50545 (/ISS) Q95M30 (/ISS)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
3 Q03145 (/ISS) Q1KL86 (/ISS) Q60750 (/ISS)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
3 P00519 (/TAS) P21860 (/TAS) P42684 (/TAS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2 P06241 (/TAS) P21860 (/TAS)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
2 P09760 (/ISS) P70451 (/ISS)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
2 A0A0R4IJK3 (/IGI) F1RCR4 (/IGI)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
2 A0A0R4IJK3 (/IMP) Q03145 (/IMP)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
2 P29317 (/ISS) Q1KL86 (/ISS)
Urogenital system development GO:0001655
The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
2 P54754 (/IMP) P54763 (/IMP)
Urogenital system development GO:0001655
The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.
2 P29323 (/ISS) P54753 (/ISS)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 P00522 (/IMP) P39688 (/IMP)
B cell homeostasis GO:0001782
The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2 P07948 (/ISS) Q07014 (/ISS)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P42682 (/IMP) Q03526 (/IMP)
Cytokine production GO:0001816
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P42681 (/ISS) Q08881 (/ISS)
Regulation of cytokine production GO:0001817
Any process that modulates the frequency, rate, or extent of production of a cytokine.
2 P07948 (/ISS) Q07014 (/ISS)
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
2 P35991 (/IMP) Q03145 (/IMP)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2 F1R5S1 (/IMP) Q5EBY4 (/IMP)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
2 P00520 (/IGI) Q4JIM5 (/IGI)
NK T cell differentiation GO:0001865
The process in which a precursor cell type acquires the specialized features of a NK T cell.
2 P42682 (/IGI) Q03526 (/IGI)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
2 P09760 (/ISS) P16591 (/ISS)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
2 P07948 (/ISS) Q07014 (/ISS)
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
2 P43403 (/TAS) Q06187 (/TAS)
Fc receptor mediated stimulatory signaling pathway GO:0002431
A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
2 P07948 (/ISS) Q07014 (/ISS)
Tolerance induction to self antigen GO:0002513
Tolerance induction directed at self antigens.
2 P07948 (/ISS) Q07014 (/ISS)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
2 P07948 (/ISS) Q07014 (/ISS)
Immune response-regulating cell surface receptor signaling pathway GO:0002768
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
2 P07948 (/ISS) Q07014 (/ISS)
Immune response-regulating cell surface receptor signaling pathway GO:0002768
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
2 P07948 (/TAS) P09769 (/TAS)
Fc receptor mediated inhibitory signaling pathway GO:0002774
A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
2 P07948 (/ISS) Q07014 (/ISS)
Endocardial cushion development GO:0003197
The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
2 P29319 (/IMP) Q61526 (/IMP)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
2 P07947 (/TAS) P42684 (/TAS)
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Substrate-dependent cell migration GO:0006929
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
2 P29321 (/ISS) P29322 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 P00519 (/IDA) P07948 (/IDA)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 P00520 (/ISO) P25911 (/ISO)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
2 P21860 (/IDA) P54757 (/IDA)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
2 Q60629 (/ISO) Q61526 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P97504 (/ISO) Q61526 (/ISO)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2 A6QR62 (/IDA) P54763 (/IDA)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P25911 (/ISO) Q61526 (/ISO)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2 P42682 (/IMP) Q03526 (/IMP)
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2 P42681 (/ISS) Q08881 (/ISS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 P00519 (/IMP) P42684 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 P00520 (/ISO) Q4JIM5 (/ISO)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
2 P07332 (/TAS) P29317 (/TAS)
Ovarian nurse cell to oocyte transport GO:0007300
Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.
2 P00528 (/IMP) P08630 (/IMP)
Female germline ring canal formation GO:0007301
Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
2 P00528 (/IMP) P08630 (/IMP)
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
2 P00528 (/IMP) P08630 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 P18106 (/IGI) Q9V9J3 (/IGI)
Dorsal closure, elongation of leading edge cells GO:0007394
The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis.
2 P18106 (/IMP) Q24145 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 P00522 (/IGI) Q03137 (/IGI)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
2 P04412 (/IMP) Q9V9J3 (/IMP)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
2 P54763 (/IMP) Q4JIM5 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
2 Q03137 (/IMP) Q4JIM5 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
2 P00522 (/IMP) Q03137 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
2 D3ZZK3 (/ISS) P54764 (/ISS)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P16591 (/TAS) P42679 (/TAS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
2 P04412 (/IMP) P08630 (/IMP)
Olfactory learning GO:0008355
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
2 P00528 (/IMP) P04412 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
2 P08103 (/ISO) P16879 (/ISO)
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 P00519 (/TAS) P42684 (/TAS)
Regulation of lamellipodium assembly GO:0010591
Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
2 P70451 (/ISO) Q03145 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q61526 (/IMP) Q9WUD9 (/IMP)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
2 E2RSH8 (/IMP) P12931 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 P39688 (/IGI) Q4JIM5 (/IGI)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 P14238 (/ISS) P16879 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
2 P09769 (/IMP) Q62844 (/IMP)
Skeletal muscle satellite cell activation GO:0014719
The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
2 P09759 (/ISS) P54762 (/ISS)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
2 P54759 (/IDA) P54763 (/IDA)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
2 P29321 (/ISS) P29322 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 P54754 (/ISO) Q03145 (/ISO)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P09760 (/ISS) P70451 (/ISS)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
2 P54756 (/ISS) Q60629 (/ISS)
Cranial nerve development GO:0021545
The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
2 Q61526 (/IMP) Q8CBF3 (/IMP)
Cerebellum morphogenesis GO:0021587
The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Optic nerve morphogenesis GO:0021631
The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
2 P54763 (/IMP) Q8CBF3 (/IMP)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
2 P54754 (/IDA) Q8CBF3 (/IDA)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
2 P54763 (/IMP) Q8CBF3 (/IMP)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
2 P09759 (/ISS) P54762 (/ISS)
Corticospinal tract morphogenesis GO:0021957
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
2 D3ZZK3 (/ISS) P54764 (/ISS)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
2 P09759 (/ISS) P54762 (/ISS)
Corpus callosum development GO:0022038
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
2 P54754 (/IMP) P54763 (/IMP)
Corpus callosum development GO:0022038
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.
2 P29323 (/ISS) P54753 (/ISS)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
2 P54753 (/IDA) Q61772 (/IDA)
Regulation of cell-cell adhesion GO:0022407
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
2 P05480 (/ISO) P54754 (/ISO)
Negative regulation of cell-cell adhesion GO:0022408
Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P00520 (/IDA) Q4JIM5 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P00528 (/IMP) P08630 (/IMP)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
2 P00519 (/TAS) P42684 (/TAS)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
2 P00519 (/TAS) P42684 (/TAS)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2 P29317 (/ISS) Q1KL86 (/ISS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 P70451 (/ISO) Q60750 (/ISO)
Karyosome formation GO:0030717
The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
2 P00528 (/IMP) P08630 (/IMP)
Ovarian fusome organization GO:0030723
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions.
2 P00528 (/IMP) P08630 (/IMP)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
2 P09760 (/ISS) P70451 (/ISS)
Negative regulation of B cell proliferation GO:0030889
Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
2 P25911 (/IMP) P35991 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
2 P05480 (/IGI) P39688 (/IGI)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
2 O13148 (/IMP) P39688 (/IMP)
Positive regulation of microtubule polymerization GO:0031116
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
2 P14238 (/ISS) P16879 (/ISS)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 P29321 (/ISS) P29322 (/ISS)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
2 P09759 (/ISS) P54762 (/ISS)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P09760 (/ISS) P16591 (/ISS)
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2 P07948 (/ISS) Q07014 (/ISS)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
2 O08644 (/IMP) Q4JIM5 (/IMP)
Non-myelinated axon ensheathment GO:0032285
The process in which a non-myelinating glial cell membrane closes around an axon.
2 F1R5S1 (/IMP) Q5EBY4 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P09760 (/ISS) P16591 (/ISS)
Interferon-gamma production GO:0032609
The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
2 P42682 (/IGI) Q03526 (/IGI)
Interleukin-4 production GO:0032633
The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P42682 (/IGI) Q03526 (/IGI)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
2 P54756 (/ISS) Q60629 (/ISS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 Q62799 (/IEP) Q9WUD9 (/IEP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 P09760 (/ISS) P16591 (/ISS)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P29320 (/IDA) Q60629 (/IDA)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P00520 (/ISO) P29319 (/ISO)
Regulation of mast cell activation GO:0033003
Any process that modulates the frequency, rate, or extent of mast cell activation.
2 P07948 (/ISS) Q07014 (/ISS)
Negative regulation of mast cell activation involved in immune response GO:0033007
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response.
2 P09760 (/ISS) P16591 (/ISS)
Mammary gland epithelial cell proliferation GO:0033598
The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
2 P29317 (/ISS) Q1KL86 (/ISS)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
2 O09127 (/IDA) P29317 (/IDA)
Regulation of cell adhesion mediated by integrin GO:0033628
Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.
2 P25911 (/ISO) Q03145 (/ISO)
Negative regulation of toll-like receptor 2 signaling pathway GO:0034136
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
2 P07948 (/ISS) Q07014 (/ISS)
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
2 P07948 (/ISS) Q07014 (/ISS)
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
2 P00528 (/IMP) Q9V9J3 (/IMP)
Adherens junction maintenance GO:0034334
The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
2 A1A5H8 (/IGI) Q6EWH2 (/IGI)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
2 P54754 (/ISO) Q60750 (/ISO)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
2 P09760 (/ISS) P16591 (/ISS)
Salivary gland cell autophagic cell death GO:0035071
The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis.
2 A0A0B4KEY9 (/IEP) A0A0B4KFU0 (/IEP)
Spiracle morphogenesis, open tracheal system GO:0035277
The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.
2 P04412 (/IMP) P08630 (/IMP)
Extracellular matrix-cell signaling GO:0035426
Any process that mediates the transfer of information between the extracellular matrix and a cell.
2 P09760 (/ISS) P16591 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 P43404 (/IMP) P48025 (/IMP)
Response to platelet-derived growth factor GO:0036119
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
2 P09760 (/ISS) P16591 (/ISS)
Insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028
The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade.
2 P09760 (/ISS) P16591 (/ISS)
Peptidyl-tyrosine autophosphorylation GO:0038083
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.
2 P00519 (/IDA) Q9H3Y6 (/IDA)
Peptidyl-tyrosine autophosphorylation GO:0038083
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.
2 P00519 (/IMP) P42680 (/IMP)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
2 P09760 (/ISS) P16591 (/ISS)
Kit signaling pathway GO:0038109
A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
2 P09760 (/ISS) P16591 (/ISS)
Regulation of epidermal growth factor receptor signaling pathway GO:0042058
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2 P09760 (/ISS) P70451 (/ISS)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2 G5EBZ8 (/IGI) Q9V9J3 (/IGI)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P43403 (/TAS) Q08881 (/TAS)
B cell activation GO:0042113
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P43403 (/TAS) Q06187 (/TAS)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 P16879 (/ISO) Q61526 (/ISO)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 P14238 (/ISS) P16879 (/ISS)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 P25911 (/IMP) P39688 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 P48025 (/IMP) Q9V9J3 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 P00519 (/IDA) Q9WUD9 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P05480 (/ISO) P08103 (/ISO)
Regulation of vascular permeability GO:0043114
Any process that modulates the extent to which blood vessels can be pervaded by fluid.
2 P07947 (/TAS) P12931 (/TAS)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
2 Q24145 (/IMP) Q9V9J3 (/IMP)
Regulation of mast cell degranulation GO:0043304
Any process that modulates the frequency, rate, or extent of mast cell degranulation.
2 P07332 (/IMP) P25911 (/IMP)
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
2 P48025 (/IMP) Q64725 (/IMP)
Positive regulation of mast cell degranulation GO:0043306
Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P09769 (/TAS) P42685 (/TAS)
Beta selection GO:0043366
The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.
2 P43404 (/IGI) P48025 (/IGI)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
2 P07948 (/ISS) Q07014 (/ISS)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
2 P29321 (/ISS) P29322 (/ISS)
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
2 Q03145 (/ISS) Q1KL86 (/ISS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
2 Q61526 (/IMP) Q62844 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
2 P54759 (/ISS) Q15375 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
2 P29321 (/ISS) P29322 (/ISS)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
2 P09760 (/ISS) P16591 (/ISS)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
2 P12931 (/ISS) Q9WUD9 (/ISS)
Positive regulation of B cell differentiation GO:0045579
Any process that activates or increases the frequency, rate or extent of B cell differentiation.
2 P43405 (/IMP) P48025 (/IMP)
Positive regulation of gamma-delta T cell differentiation GO:0045588
Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.
2 P06240 (/IMP) P48025 (/IMP)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
2 P14238 (/ISS) P16879 (/ISS)
Positive regulation of myeloid cell differentiation GO:0045639
Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.
2 P14238 (/ISS) P16879 (/ISS)
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
2 P07948 (/ISS) Q07014 (/ISS)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
2 P29317 (/ISS) Q1KL86 (/ISS)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
2 P00528 (/IGI) Q9V9J3 (/IGI)
CAMP metabolic process GO:0046058
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
2 Q03145 (/ISS) Q1KL86 (/ISS)
Alpha-beta T cell differentiation GO:0046632
The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
2 P43404 (/IGI) P48025 (/IGI)
Positive regulation of alpha-beta T cell proliferation GO:0046641
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
2 P43404 (/IGI) P48025 (/IGI)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 P08631 (/IMP) P43404 (/IMP)
Dorsal appendage formation GO:0046843
Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
2 P04412 (/IMP) Q24145 (/IMP)
Bone remodeling GO:0046849
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
2 P29317 (/ISS) Q1KL86 (/ISS)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2 P00520 (/IDA) P70451 (/IDA)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2 P09760 (/ISS) P16591 (/ISS)
Autophagic cell death GO:0048102
A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
2 A0A0B4KEY9 (/IEP) A0A0B4KFU0 (/IEP)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
2 P48025 (/IMP) Q03145 (/IMP)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
2 P00520 (/IMP) P54754 (/IMP)
Digestive tract morphogenesis GO:0048546
The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
2 P04412 (/IMP) P54754 (/IMP)
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
2 P54763 (/IMP) Q8CBF3 (/IMP)
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
2 D3ZZK3 (/IMP) Q03137 (/IMP)
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
2 D3ZZK3 (/ISS) P54764 (/ISS)
Regulation of astrocyte differentiation GO:0048710
Any process that modulates the frequency, rate or extent of astrocyte differentiation.
2 D3ZZK3 (/ISS) P54764 (/ISS)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
2 P04412 (/IMP) Q9V9J3 (/IMP)
Branching morphogenesis of a nerve GO:0048755
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
2 P54759 (/ISS) Q15375 (/ISS)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
2 Q03145 (/ISS) Q1KL86 (/ISS)
Posterior lateral line neuromast development GO:0048919
The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.
2 F1R5S1 (/IMP) Q5EBY4 (/IMP)
Cytokine secretion GO:0050663
The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
2 O08644 (/IMP) Q07014 (/IMP)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 Q15375 (/IDA) Q61772 (/IDA)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 O42422 (/ISS) P54759 (/ISS)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 E2RSH8 (/IC) P12931 (/IC)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P00520 (/ISO) P24604 (/ISO)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
2 P54754 (/IDA) P54763 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 P08103 (/IGI) P14234 (/IGI)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 P14234 (/IMP) Q03145 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
2 P09769 (/ISS) Q6P6U0 (/ISS)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
2 P43404 (/IMP) P48025 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
2 P42681 (/ISS) Q08881 (/ISS)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
2 F1N9Y5 (/IMP) P00520 (/IMP)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
2 P16277 (/ISO) P24604 (/ISO)
Regulation of B cell receptor signaling pathway GO:0050855
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2 P07948 (/ISS) Q07014 (/ISS)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Diapedesis GO:0050904
The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.
2 P09760 (/ISS) P16591 (/ISS)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
2 P54759 (/ISS) Q15375 (/ISS)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
2 P09759 (/ISS) P54762 (/ISS)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
2 P18106 (/IMP) Q9V9J3 (/IMP)
Regulation of sequence-specific DNA binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P08631 (/IMP) P43405 (/IMP)
Regulation of sequence-specific DNA binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P08103 (/ISO) P48025 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 P09760 (/ISS) P70451 (/ISS)
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
2 P00519 (/TAS) P00520 (/TAS)
Positive regulation of oxidoreductase activity GO:0051353
Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
2 P00519 (/IDA) P42684 (/IDA)
Positive regulation of oxidoreductase activity GO:0051353
Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
2 P00520 (/ISO) Q4JIM5 (/ISO)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q03145 (/ISS) Q1KL86 (/ISS)
Cardiac myofibril assembly GO:0055003
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
2 F1R5S1 (/IMP) Q5EBY4 (/IMP)
Bergmann glial cell differentiation GO:0060020
The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Palate development GO:0060021
The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities.
2 P54754 (/IMP) P54763 (/IMP)
Palate development GO:0060021
The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities.
2 P29323 (/ISS) P54753 (/ISS)
Convergent extension GO:0060026
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.
2 A0A0R4IJK3 (/IGI) F1RCR4 (/IGI)
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
2 A0JMN4 (/IMP) F1QBS0 (/IMP)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
2 P29317 (/IMP) Q8CBF3 (/IMP)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
2 Q03145 (/ISO) Q8CBF3 (/ISO)
Heart trabecula formation GO:0060347
The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.
2 F1R5S1 (/IMP) Q5EBY4 (/IMP)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
2 P07948 (/TAS) P25911 (/TAS)
Branching involved in mammary gland duct morphogenesis GO:0060444
The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
2 P05480 (/IMP) Q03145 (/IMP)
Branching involved in mammary gland duct morphogenesis GO:0060444
The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
2 P29317 (/ISS) Q1KL86 (/ISS)
Neuroepithelial cell differentiation GO:0060563
The process in which epiblast cells acquire specialized features of neuroepithelial cells.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Cell migration involved in heart development GO:0060973
The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.
2 F1R5S1 (/IMP) Q5EBY4 (/IMP)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
2 P54757 (/IDA) P54763 (/IDA)
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
2 D3ZZK3 (/ISS) P54764 (/ISS)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
2 P54756 (/ISS) P54757 (/ISS)
Neural precursor cell proliferation GO:0061351
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.
2 P09759 (/ISS) P54762 (/ISS)
Lens fiber cell morphogenesis GO:0070309
The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
2 P29317 (/ISS) Q1KL86 (/ISS)
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P54762 (/IDA) Q15375 (/IDA)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P00520 (/IMP) P25911 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 P07948 (/ISS) Q07014 (/ISS)
Negative regulation of mast cell proliferation GO:0070667
Any process that stops, prevents or reduces the rate or extent of mast cell proliferation.
2 P07948 (/ISS) Q07014 (/ISS)
Response to growth factor GO:0070848
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
2 Q03145 (/ISS) Q1KL86 (/ISS)
Nephric duct morphogenesis GO:0072178
The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.
2 Q03137 (/IGI) Q61772 (/IGI)
Cardiovascular system development GO:0072358
The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Positive regulation of establishment of protein localization to plasma membrane GO:0090004
Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane.
2 Q03145 (/ISS) Q1KL86 (/ISS)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
2 P00528 (/IMP) Q9V9J3 (/IMP)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
2 P25911 (/IMP) P48025 (/IMP)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
2 Q03145 (/ISO) Q60750 (/ISO)
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
2 P07948 (/ISS) Q07014 (/ISS)
Fasciculation of sensory neuron axon GO:0097155
The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
2 P29319 (/IMP) Q03137 (/IMP)
Fasciculation of motor neuron axon GO:0097156
The collection of motor neuron axons into a bundle of rods, known as a fascicle.
2 P29319 (/IMP) Q03137 (/IMP)
Positive regulation of interleukin-2 secretion GO:1900042
Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Negative regulation of intracellular signal transduction GO:1902532
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
2 P07948 (/ISS) Q07014 (/ISS)
Positive regulation of interferon-gamma secretion GO:1902715
Any process that activates or increases the frequency, rate or extent of interferon-gamma secretion.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Negative regulation of skeletal muscle satellite cell proliferation GO:1902723
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation.
2 P09759 (/ISS) P54762 (/ISS)
Negative regulation of satellite cell differentiation GO:1902725
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation.
2 P09759 (/ISS) P54762 (/ISS)
Regulation of extracellular matrix organization GO:1903053
Any process that modulates the frequency, rate or extent of extracellular matrix organization.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096
Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
2 P14238 (/ISS) P16879 (/ISS)
Regulation of actin cytoskeleton reorganization GO:2000249
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
2 P00519 (/TAS) P42684 (/TAS)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
2 P07332 (/IMP) P08631 (/IMP)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
2 P08103 (/ISO) P16879 (/ISO)
Negative regulation of endothelial cell apoptotic process GO:2000352
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
2 P00520 (/IGI) Q4JIM5 (/IGI)
Positive regulation of lamellipodium morphogenesis GO:2000394
Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.
2 E2RSH8 (/IMP) P12931 (/IMP)
Positive regulation of T cell costimulation GO:2000525
Any process that activates or increases the frequency, rate or extent of T cell costimulation.
2 O08644 (/IGI) P54761 (/IGI)
Positive regulation of dendritic cell apoptotic process GO:2000670
Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.
2 P07948 (/ISS) Q07014 (/ISS)
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
1 P03949 (/IGI)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
1 P04412 (/TAS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P42685 (/IDA)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q922K9 (/ISO)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P48025 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P48025 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 P16591 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 P70451 (/ISO)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 P16591 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 P70451 (/ISO)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 P00519 (/TAS)
Embryonic axis specification GO:0000578
The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
1 P04412 (/NAS)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 P54763 (/IGI)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
1 Q03145 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 P54762 (/IDA)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q8CBF3 (/ISO)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
1 O61460 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 Q03145 (/IMP)
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
1 P16879 (/IDA)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
1 Q03145 (/IMP)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
1 P04412 (/IMP)
Fever generation GO:0001660
The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
1 O08680 (/IEP)
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
1 Q6EWH2 (/IMP)
Cell fate determination GO:0001709
A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
1 P04412 (/TAS)
Oenocyte differentiation GO:0001742
The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.
1 P04412 (/TAS)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 P04412 (/TAS)
Compound eye photoreceptor cell differentiation GO:0001751
The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
1 P04412 (/IMP)
Compound eye photoreceptor cell differentiation GO:0001751
The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
1 P04412 (/TAS)
Compound eye photoreceptor fate commitment GO:0001752
The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.
1 P04412 (/TAS)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 F1Q9D9 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q07496 (/NAS)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 P39688 (/IGI)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q05876 (/ISS)
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 P09759 (/IGI)
Immunological synapse formation GO:0001771
The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 Q8CBF3 (/ISO)
B cell homeostasis GO:0001782
The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
1 P25911 (/IMP)
Type IV hypersensitivity GO:0001806
An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.
1 O08644 (/IMP)
Regulation of cytokine production GO:0001817
Any process that modulates the frequency, rate, or extent of production of a cytokine.
1 P25911 (/IMP)
Serotonin secretion GO:0001820
The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
1 P48025 (/IMP)
NK T cell differentiation GO:0001865
The process in which a precursor cell type acquires the specialized features of a NK T cell.
1 Q03526 (/IMP)
Response to yeast GO:0001878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.
1 Q1JPZ3 (/IDA)
B-1 B cell homeostasis GO:0001922
The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.
1 P00520 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 P70451 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 P07948 (/TAS)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 P25911 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q61772 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P00519 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P00520 (/ISO)
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
1 P48025 (/IMP)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
1 P21709 (/IDA)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
1 Q60750 (/ISO)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
1 Q60750 (/ISS)
Morphogenesis of an epithelium GO:0002009
The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
1 P04412 (/IMP)
Morphogenesis of an epithelium GO:0002009
The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
1 P00522 (/NAS)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 P54760 (/IDA)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 P54761 (/ISO)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 P54761 (/ISS)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
1 Q03145 (/IMP)
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
1 P48025 (/IMP)
Aggressive behavior GO:0002118
A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.
1 Q4JIM5 (/IMP)
Macrophage activation involved in immune response GO:0002281
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 P48025 (/IMP)
Neutrophil activation involved in immune response GO:0002283
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 P48025 (/IMP)
B cell proliferation involved in immune response GO:0002322
The expansion of a B cell population by cell division following B cell activation during an immune response.
1 P00520 (/IGI)
B cell proliferation involved in immune response GO:0002322
The expansion of a B cell population by cell division following B cell activation during an immune response.
1 P00520 (/IMP)
Transitional one stage B cell differentiation GO:0002333
The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.
1 P00520 (/IMP)
B cell affinity maturation GO:0002344
The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
1 P35991 (/IMP)
Leukocyte activation involved in immune response GO:0002366
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 P48025 (/IMP)
Fc receptor mediated stimulatory signaling pathway GO:0002431
A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
1 P25911 (/IMP)
T cell mediated immunity GO:0002456
Any process involved in the carrying out of an immune response by a T cell.
1 O08644 (/IMP)
Tolerance induction to self antigen GO:0002513
Tolerance induction directed at self antigens.
1 P25911 (/IMP)
Tolerance induction to self antigen GO:0002513
Tolerance induction directed at self antigens.
1 P07948 (/TAS)
Leukocyte migration involved in immune response GO:0002522
The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.
1 P08631 (/TAS)
Serotonin secretion by platelet GO:0002554
The regulated release of serotonin by a platelet or group of platelets.
1 P48025 (/IMP)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 P25911 (/IMP)
Regulation of B cell cytokine production GO:0002721
Any process that modulates the frequency, rate, or extent of B cell cytokine production.
1 Q06187 (/TAS)
MyD88-dependent toll-like receptor signaling pathway GO:0002755
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 Q06187 (/TAS)
Innate immune response-activating signal transduction GO:0002758
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response.
1 P08631 (/TAS)
Negative regulation of myeloid leukocyte differentiation GO:0002762
Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
1 P25911 (/IMP)
Immune response-regulating cell surface receptor signaling pathway GO:0002768
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
1 P25911 (/IMP)
Fc receptor mediated inhibitory signaling pathway GO:0002774
A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
1 P25911 (/IMP)
Regulation of B cell apoptotic process GO:0002902
Any process that modulates the frequency, rate, or extent of B cell apoptotic process.
1 P25911 (/IMP)
Regulation of B cell apoptotic process GO:0002902
Any process that modulates the frequency, rate, or extent of B cell apoptotic process.
1 Q06187 (/TAS)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P54761 (/IMP)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P54760 (/ISS)
Heart process GO:0003015
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P04412 (/IMP)
Epithelial cell morphogenesis GO:0003382
The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.
1 P00522 (/IMP)
Planar cell polarity pathway involved in axis elongation GO:0003402
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.
1 P00522 (/IMP)
Optic vesicle morphogenesis GO:0003404
The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
1 O13148 (/IGI)
Neural retina development GO:0003407
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
1 F1NHC7 (/IDA)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
1 Q9V9J3 (/IDA)
Mismatch repair GO:0006298
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
1 P00519 (/TAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P00519 (/TAS)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P42681 (/IDA)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P42682 (/ISO)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
1 P00519 (/NAS)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 P21709 (/IDA)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 Q60750 (/ISO)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 Q60750 (/ISS)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 P51813 (/TAS)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P06241 (/NAS)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
1 P06239 (/IEP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q01621 (/IEP)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 P06239 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 P06240 (/ISO)
Substrate-dependent cell migration GO:0006929
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
1 O09127 (/IDA)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
1 Q4JIM5 (/IGI)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 P70451 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 Q03145 (/IMP)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P43403 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P43404 (/ISO)
Cellular defense response GO:0006968
A defense response that is mediated by cells.
1 Q08881 (/TAS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 P00520 (/ISS)
DNA damage induced protein phosphorylation GO:0006975
The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage.
1 P00519 (/IDA)
DNA damage induced protein phosphorylation GO:0006975
The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage.
1 P00520 (/ISO)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P00519 (/IGI)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P00520 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P00520 (/ISO)
Response to sterol depletion GO:0006991
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q07014 (/IEP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 Q4JIM5 (/IDA)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
1 P00519 (/TAS)
Centrosome cycle GO:0007098
The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
1 P16879 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P54760 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P70451 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P54761 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P54761 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P08631 (/TAS)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 P43405 (/IDA)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 P48025 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P48025 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q60750 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q60750 (/ISS)
Enzyme linked receptor protein signaling pathway GO:0007167
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P48025 (/IDA)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9V9J3 (/IGI)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P07948 (/IMP)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P21860 (/ISS)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62799 (/TAS)
Signal complex assembly GO:0007172
The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.
1 P12931 (/TAS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q9WUD9 (/IEP)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q62799 (/IMP)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P12931 (/IMP)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05480 (/ISO)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P48025 (/TAS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P42680 (/IDA)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P43405 (/NAS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P08631 (/TAS)
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
1 P35991 (/IMP)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q24145 (/IGI)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q24145 (/IMP)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q24145 (/NAS)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
1 P48025 (/IMP)
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 P16591 (/IDA)
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 P70451 (/ISO)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P00522 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P03949 (/IMP)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
1 P04412 (/IGI)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
1 P04412 (/IMP)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
1 P04412 (/TAS)
Female germline ring canal formation GO:0007301
Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
1 P08630 (/IDA)
Cytoplasmic transport, nurse cell to oocyte GO:0007303
The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte.
1 P00522 (/IMP)
Eggshell chorion assembly GO:0007306
Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell.
1 Q24145 (/IMP)
Oocyte axis specification GO:0007309
The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.
1 P04412 (/IMP)
Oocyte dorsal/ventral axis specification GO:0007310
The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.
1 P04412 (/NAS)
Oocyte anterior/posterior axis specification GO:0007314
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
1 P04412 (/NAS)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 P04412 (/TAS)
Blastoderm segmentation GO:0007350
The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.
1 P04412 (/TAS)
Segment polarity determination GO:0007367
Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.
1 P04412 (/IMP)
Gastrulation GO:0007369
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
1 P04412 (/TAS)
Ventral furrow formation GO:0007370
Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.
1 P00522 (/IMP)
Germ-band shortening GO:0007390
The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.
1 P04412 (/IMP)
Germ-band shortening GO:0007390
The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.
1 P04412 (/TAS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
1 P00522 (/NAS)
Dorsal closure, spreading of leading edge cells GO:0007395
Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa.
1 Q9V9J3 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P29323 (/TAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 Q62799 (/IEP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 P00522 (/IGI)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 O61460 (/IMP)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P00522 (/IGI)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
1 P00522 (/IGI)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
1 P00522 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 F1NHC7 (/IDA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P32577 (/IEP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q61772 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P04412 (/TAS)
Stomatogastric nervous system development GO:0007421
The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure.
1 P04412 (/TAS)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 P21860 (/ISS)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
1 P04412 (/TAS)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
1 P04412 (/IMP)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
1 P04412 (/IMP)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
1 P04412 (/TAS)
Imaginal disc development GO:0007444
The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.).
1 P04412 (/IMP)
Imaginal disc development GO:0007444
The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.).
1 P04412 (/NAS)
Imaginal disc development GO:0007444
The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.).
1 P04412 (/TAS)
Imaginal disc pattern formation GO:0007447
The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.
1 P04412 (/NAS)
Eye-antennal disc morphogenesis GO:0007455
The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps.
1 P04412 (/IMP)
Progression of morphogenetic furrow involved in compound eye morphogenesis GO:0007458
The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc.
1 P04412 (/TAS)
Antennal development GO:0007469
The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli.
1 P04412 (/NAS)
Wing disc morphogenesis GO:0007472
The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura.
1 P04412 (/IMP)
Wing disc proximal/distal pattern formation GO:0007473
The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing.
1 P04412 (/TAS)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
1 P04412 (/TAS)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
1 P04412 (/NAS)
Notum development GO:0007477
The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure.
1 P04412 (/IMP)
Leg disc proximal/distal pattern formation GO:0007479
The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg.
1 P04412 (/IMP)
Leg disc proximal/distal pattern formation GO:0007479
The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg.
1