The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Globins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5159: Hemoglobin beta chain subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 36 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 D9YZU9 (/IPI) P01946 (/IPI) P01948 (/IPI) P01965 (/IPI) P01966 (/IPI) P02008 (/IPI) P02042 (/IPI) P02067 (/IPI) P02100 (/IPI) P09105 (/IPI)
(6 more)
Oxygen transporter activity GO:0005344
Enables the directed movement of oxygen into, out of or within a cell, or between cells.
9 O24521 (/ISS) P80043 (/ISS) P83271 (/ISS) P84653 (/ISS) P86879 (/ISS) P86882 (/ISS) P86887 (/ISS) Q90485 (/ISS) Q90486 (/ISS)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
9 B3EWR7 (/IDA) B3EWR8 (/IDA) O24520 (/IDA) P68871 (/IDA) P84790 (/IDA) P84791 (/IDA) P84792 (/IDA) Q5QSA9 (/IDA) Q90YJ2 (/IDA)
Nitric oxide dioxygenase activity GO:0008941
Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.
4 P24232 (/IDA) P39662 (/IDA) Q2U124 (/IDA) Q2UDH4 (/IDA)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
4 A0A091Q983 (/ISS) A0A093BTA2 (/ISS) P02112 (/ISS) Q81T23 (/ISS)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
4 O88754 (/IDA) P24232 (/IDA) Q63910 (/IDA) Q921A4 (/IDA)
Oxygen transporter activity GO:0005344
Enables the directed movement of oxygen into, out of or within a cell, or between cells.
3 P83623 (/IDA) P83624 (/IDA) P83625 (/IDA)
Oxygen transporter activity GO:0005344
Enables the directed movement of oxygen into, out of or within a cell, or between cells.
3 P68871 (/NAS) Q14473 (/NAS) Q8WWM9 (/NAS)
Hemoglobin alpha binding GO:0031721
Interacting selectively and non-covalently with a hemoglobin alpha chain.
3 O88752 (/IDA) O88754 (/IDA) P02091 (/IDA)
Nitrite reductase activity GO:0098809
Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor.
3 Q575S8 (/IDA) Q8UUR3 (/IDA) Q90YJ2 (/IDA)
6,7-dihydropteridine reductase activity GO:0004155
Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.
2 Q81T23 (/ISS) Q9KMY3 (/ISS)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
2 Q8WWM9 (/ISS) Q9CX80 (/ISS)
Oxygen transporter activity GO:0005344
Enables the directed movement of oxygen into, out of or within a cell, or between cells.
2 P02008 (/TAS) P02100 (/TAS)
Nitric oxide dioxygenase activity GO:0008941
Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.
2 P24232 (/IMP) Q59MV9 (/IMP)
Nitric oxide dioxygenase activity GO:0008941
Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.
2 Q81T23 (/ISS) Q9URY5 (/ISS)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
2 A8DUK4 (/ISO) E9Q223 (/ISO)
Hemoglobin binding GO:0030492
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
2 A8DUK4 (/ISO) E9Q223 (/ISO)
Riboflavin reductase (NADPH) activity GO:0042602
Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.
2 Q2U124 (/IDA) Q2UDH4 (/IDA)
Carbon monoxide binding GO:0070025
Interacting selectively and non-covalently with carbon monoxide (CO).
2 A0A091Q983 (/ISS) A0A093BTA2 (/ISS)
Beta-amyloid binding GO:0001540
Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor.
1 P01946 (/IDA)
Catalase activity GO:0004096
Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
1 Q921A4 (/IDA)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
1 Q921A4 (/IDA)
Oxygen transporter activity GO:0005344
Enables the directed movement of oxygen into, out of or within a cell, or between cells.
1 P02088 (/IMP)
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 P24232 (/IDA)
Nitric oxide dioxygenase activity GO:0008941
Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.
1 Q8WWM9 (/TAS)
Nitric oxide reductase activity GO:0016966
Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide.
1 P39676 (/IMP)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
1 P02089 (/IMP)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
1 Q4VIX3 (/TAS)
Hemoglobin binding GO:0030492
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
1 P68871 (/IDA)
Hemoglobin binding GO:0030492
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
1 P02112 (/ISS)
Hemoglobin beta binding GO:0031722
Interacting selectively and non-covalently with a hemoglobin beta chain.
1 P02091 (/IDA)
Hydroperoxide reductase activity GO:0032843
Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol.
1 P24232 (/IDA)
Organic acid binding GO:0043177
Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage.
1 Q63910 (/IPI)
Fatty acid peroxidase activity GO:0047888
Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal.
1 Q921A4 (/IDA)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
1 Q9URY5 (/ISM)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
1 P24232 (/IDA)

There are 74 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxygen transport GO:0015671
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
9 P80043 (/ISS) P83271 (/ISS) P84653 (/ISS) P86879 (/ISS) P86882 (/ISS) P86887 (/ISS) Q81T23 (/ISS) Q90485 (/ISS) Q90486 (/ISS)
Oxygen transport GO:0015671
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
7 P02091 (/IDA) P83623 (/IDA) P83624 (/IDA) P83625 (/IDA) P84790 (/IDA) P84791 (/IDA) P84792 (/IDA)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
6 O88752 (/IDA) O88754 (/IDA) P02091 (/IDA) P68871 (/IDA) P69905 (/IDA) Q63910 (/IDA)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
5 P02042 (/TAS) P02100 (/TAS) P68871 (/TAS) P69891 (/TAS) P69892 (/TAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
4 Q5QSA9 (/IDA) Q90486 (/IDA) Q90487 (/IDA) Q90YJ2 (/IDA)
Erythrocyte development GO:0048821
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
4 P01942 (/IGI) P02088 (/IGI) P02089 (/IGI) Q91VB8 (/IGI)
Oxygen transport GO:0015671
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P09105 (/TAS) P68871 (/TAS) P69905 (/TAS)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P02104 (/IGI) P04444 (/IGI)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P02104 (/IMP) P06467 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q4VIX3 (/IEP) Q921A4 (/IEP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
2 P01942 (/IGI) Q91VB8 (/IGI)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2 P68871 (/TAS) P69905 (/TAS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q8WWM9 (/ISS) Q9CX80 (/ISS)
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2 P68871 (/IDA) P69905 (/IDA)
Oxygen transport GO:0015671
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P68871 (/NAS) Q8WWM9 (/NAS)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P68871 (/TAS) P69905 (/TAS)
Cytolysis GO:0019835
The rupture of cell membranes and the loss of cytoplasm.
2 Q6S9E2 (/IMP) V5N6P9 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
2 Q90485 (/ISS) Q90486 (/ISS)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 P68871 (/IDA) P69905 (/IDA)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
2 P68871 (/IDA) P69905 (/IDA)
Cellular response to nitrosative stress GO:0071500
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
2 Q2U124 (/IMP) Q5AX11 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 O24520 (/TAS)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
1 P01948 (/IDA)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 O24521 (/IMP)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
1 P02091 (/IDA)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q81T23 (/ISS)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q9KMY3 (/ISS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q921A4 (/IDA)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 A0A1D8PD58 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q59MV9 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 Q59MV9 (/IMP)
Negative regulation of fibroblast migration GO:0010764
Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
1 Q921A4 (/IDA)
Regulation of eIF2 alpha phosphorylation by heme GO:0010999
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels.
1 P02088 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 O88752 (/IEP)
Oxygen transport GO:0015671
The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P02088 (/IMP)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
1 Q921A4 (/IDA)
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
1 O24521 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 P02088 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q90487 (/NAS)
Nitric oxide transport GO:0030185
The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P68871 (/NAS)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q59MV9 (/IMP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 A0A0G2JSV6 (/IEP)
Negative regulation of collagen biosynthetic process GO:0032966
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
1 Q921A4 (/IDA)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P39676 (/IDA)
Response to stilbenoid GO:0035634
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.
1 P01942 (/IEP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
1 A0A1D8PD58 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
1 A0A1D8PD58 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q4VIX3 (/IEP)
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
1 P06467 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P68871 (/TAS)
Sexual sporulation resulting in formation of a cellular spore GO:0043935
The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
1 Q5AX11 (/IMP)
Negative regulation of sexual sporulation resulting in formation of a cellular spore GO:0043942
Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis.
1 Q5AX11 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q59MV9 (/IMP)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 P68871 (/NAS)
Sterigmatocystin biosynthetic process GO:0045461
The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
1 Q5B7F8 (/IGI)
Sterigmatocystin biosynthetic process GO:0045461
The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
1 Q5AX11 (/IMP)
Positive regulation of myeloid cell differentiation GO:0045639
Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.
1 P02089 (/IMP)
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
1 P02089 (/IMP)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
1 P01946 (/IDA)
Nitric oxide catabolic process GO:0046210
The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
1 Q59MV9 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q8UUR3 (/IEP)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
1 Q4VIX3 (/IEP)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
1 Q8WWM9 (/TAS)
Response to nitrosative stress GO:0051409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
1 P24232 (/IEP)
Response to nitrosative stress GO:0051409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
1 P24232 (/IMP)
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
1 P01946 (/IDA)
Response to defense-related host nitric oxide production GO:0052565
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q59MV9 (/IMP)
Renal absorption GO:0070293
A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).
1 P68871 (/IMP)
Cellular detoxification of nitrogen compound GO:0070458
Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
1 Q9URY5 (/IC)
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
1 P68871 (/IMP)
Cellular response to misfolded protein GO:0071218
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
1 P39676 (/IMP)
Cellular response to nitrosative stress GO:0071500
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
1 Q59MV9 (/IEP)
Cellular response to reactive nitrogen species GO:1902170
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus.
1 P39676 (/IMP)
Negative regulation of hepatic stellate cell activation GO:2000490
Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation.
1 Q921A4 (/IDA)

There are 44 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hemoglobin complex GO:0005833
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.
13 O88752 (/IDA) O88754 (/IDA) P02088 (/IDA) P02091 (/IDA) P68871 (/IDA) P69905 (/IDA) P83623 (/IDA) P83624 (/IDA) P83625 (/IDA) P84790 (/IDA)
(3 more)
Hemoglobin complex GO:0005833
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.
8 P80043 (/ISS) P83271 (/ISS) P84653 (/ISS) P86879 (/ISS) P86882 (/ISS) P86887 (/ISS) Q90485 (/ISS) Q90486 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P02042 (/TAS) P02100 (/TAS) P68871 (/TAS) P69891 (/TAS) P69892 (/TAS) P69905 (/TAS) Q8WWM9 (/TAS)
Hemoglobin complex GO:0005833
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.
6 P02008 (/TAS) P02042 (/TAS) P02100 (/TAS) P09105 (/TAS) P68871 (/TAS) P69905 (/TAS)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
6 A8DUK4 (/ISO) E9Q223 (/ISO) P01942 (/ISO) P02104 (/ISO) P04444 (/ISO) Q91VB8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 O24520 (/IDA) P39676 (/IDA) Q2U124 (/IDA) Q6FL28 (/IDA) Q9URY5 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 A8DUK4 (/ISO) E9Q223 (/ISO) P01942 (/ISO) P06467 (/ISO) Q91VB8 (/ISO)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
5 P02042 (/IDA) P02100 (/IDA) P68871 (/IDA) P69892 (/IDA) P69905 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P01994 (/IDA) P02112 (/IDA) P68871 (/IDA) P69905 (/IDA)
Hemoglobin complex GO:0005833
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.
4 A8DUK4 (/ISO) E9Q223 (/ISO) P01942 (/ISO) Q91VB8 (/ISO)
Haptoglobin-hemoglobin complex GO:0031838
A protein complex formed by the stable binding of a haptoglobin to hemoglobin.
4 A8DUK4 (/ISO) E9Q223 (/ISO) P01942 (/ISO) Q91VB8 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P02008 (/IDA) P68871 (/IDA) P69905 (/IDA) Q6B0K9 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
3 P02112 (/IDA) Q6S9E2 (/IDA) V5N6P9 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
3 K7EIM9 (/IDA) K7EMC7 (/IDA) Q8WWM9 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P68871 (/TAS) P69905 (/TAS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 A2R2Z2 (/IDA) Q5AX11 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q4VIX3 (/IDA) Q9URY5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q4VIX3 (/IDA) Q921A4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 A0A091Q983 (/ISS) A0A093BTA2 (/ISS)
Hemoglobin complex GO:0005833
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.
2 P02088 (/IMP) P02089 (/IMP)
Hemoglobin complex GO:0005833
An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.
2 P68871 (/NAS) Q90487 (/NAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P69905 (/IDA) Q5QSA9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P01942 (/ISO) Q91VB8 (/ISO)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
2 P01942 (/ISO) Q91VB8 (/ISO)
Haptoglobin-hemoglobin complex GO:0031838
A protein complex formed by the stable binding of a haptoglobin to hemoglobin.
2 P68871 (/IDA) P69905 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
2 P01942 (/IDA) P02088 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
2 Q54D73 (/IDA) Q9UAG7 (/IDA)
Endocytic vesicle lumen GO:0071682
The volume enclosed by the membrane of an endocytic vesicle.
2 P68871 (/TAS) P69905 (/TAS)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 O24520 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9URY5 (/IC)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q921A4 (/NAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9URY5 (/IC)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q2UDH4 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P39676 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O24520 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 O24520 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
1 P39676 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q9CX80 (/ISO)
Cytosolic small ribosomal subunit GO:0022627
The small subunit of a ribosome located in the cytosol.
1 P69905 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9CX80 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9CX80 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P01946 (/IDA)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
1 P68871 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
1 P68871 (/TAS)