The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Topoisomerase I, domain 2

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6239: Putative DNA topoisomerase I

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA topoisomerase. [EC:]
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
  • Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC
12335 A0A009FW92 A0A009HH81 A0A009I660 A0A009IAR7 A0A009J945 A0A009K0Y5 A0A009LL15 A0A009NJI8 A0A009QQY8 A0A009QU39
(12325 more...)
DNA topoisomerase (ATP-hydrolyzing). [EC:]
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
  • Can introduce negative superhelical turns into double-stranded circular DNA.
  • One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC
1 A0A1L9EX26
Carboxyvinyl-carboxyphosphonate phosphorylmutase. [EC:]
1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO(2).
  • Catalyzes the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.
1 A0A1L3TCF5