The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
1.10.10.1180
superfamily
This superfamily entry represents the winged-helix domain located at the C-terminal end of MAN1, an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation. The C-terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad PMID:16648637. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands PMID:15611647. The carboxyl-terminal nucleoplasmic region of MAN1, comprising residues 655-910, exhibits two potential globular domains, an alpha/beta structure which corresponds to a winged-helix domain. The first region of the domain is conserved in all MAN1 analogs. The N-terminal half of the domain is mainly alpha-helical, whereas the C-terminal half is composed of two large beta-strands arranged in a twisted anti-parallel beta-sheet PMID:16648637.
Structures | |
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Domains: | 1 |
Domain clusters (>95% seq id): | 1 |
Domain clusters (>35% seq id): | 1 |
Unique PDBs: | 1 |
Alignments | |
Structural Clusters (5A): | 1 |
Structural Clusters (9A): | 1 |
FunFam Clusters: | 0 |
Function | |
Unique EC: | 2 |
Unique GO: | 40 |
Taxonomy | |
Unique Species: | 888 |