The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 266694: Transcriptional repressor, LexA family

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
26 A0A072Z841 (/IDA) A0QVY5 (/IDA) A1B3Z0 (/IDA) C1F978 (/IDA) D5ALN0 (/IDA) I6Y1J7 (/IDA) P0A153 (/IDA) P0A7C2 (/IDA) P31080 (/IDA) P37452 (/IDA)
(16 more)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
26 A0A072Z841 (/IDA) A0QVY5 (/IDA) A1B3Z0 (/IDA) C1F978 (/IDA) D5ALN0 (/IDA) I6Y1J7 (/IDA) P0A153 (/IDA) P0A7C2 (/IDA) P31080 (/IDA) P37452 (/IDA)
(16 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
14 A0L9E2 (/IDA) A9BGA3 (/IDA) P0DN68 (/IDA) P31080 (/IDA) P37452 (/IDA) P60511 (/IDA) P61608 (/IDA) P73722 (/IDA) Q49848 (/IDA) Q87KN2 (/IDA)
(4 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
9 A0QVY5 (/EXP) A1B3Z0 (/EXP) P59479 (/EXP) P60511 (/EXP) Q1D406 (/EXP) Q6MHM9 (/EXP) Q8PN77 (/EXP) Q9PH24 (/EXP) Q9ZFA4 (/EXP)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
9 A0QVY5 (/EXP) A1B3Z0 (/EXP) P59479 (/EXP) P60511 (/EXP) Q1D406 (/EXP) Q6MHM9 (/EXP) Q8PN77 (/EXP) Q9PH24 (/EXP) Q9ZFA4 (/EXP)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
8 A0L9E2 (/EXP) A9BGA3 (/EXP) P0DN68 (/EXP) P61608 (/EXP) P73722 (/EXP) Q49848 (/EXP) Q8F663 (/EXP) Q8YMM5 (/EXP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
6 P0A7C2 (/IPI) P60511 (/IPI) Q1D406 (/IPI) Q6MHM9 (/IPI) Q9KVP9 (/IPI) Q9ZFA4 (/IPI)
Bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
6 P0A7C2 (/IPI) P60511 (/IPI) Q1D406 (/IPI) Q6MHM9 (/IPI) Q9KVP9 (/IPI) Q9ZFA4 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
6 A9BGA3 (/IPI) P0A7C2 (/IPI) P0DN68 (/IPI) P73722 (/IPI) Q8F663 (/IPI) Q8YMM5 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P0A7C2 (/IDA) P9WHR7 (/IDA)
Bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 P73722 (/IDA)
Transcription factor activity, sequence-specific DNA binding GO:0003700
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
1 Q9KVP9 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
26 A0A072Z841 (/EXP) B8CUX0 (/EXP) C1F978 (/EXP) D5ALN0 (/EXP) I6Y1J7 (/EXP) P0A153 (/EXP) P0A7C2 (/EXP) P31080 (/EXP) P37452 (/EXP) P44858 (/EXP)
(16 more)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
15 I6Y1J7 (/EXP) P31080 (/EXP) P37452 (/EXP) P44858 (/EXP) P60511 (/EXP) P61609 (/EXP) P61611 (/EXP) Q6MHM9 (/EXP) Q72P22 (/EXP) Q8PN77 (/EXP)
(5 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
5 P0A7C2 (/IEP) P44858 (/IEP) P60511 (/IEP) P73722 (/IEP) Q9ZFA4 (/IEP)
Regulation of DNA repair GO:0006282
Any process that modulates the frequency, rate or extent of DNA repair.
3 P61608 (/ISS) P61609 (/ISS) Q9KVP9 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 P61608 (/ISS) P61609 (/ISS) Q9KVP9 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 B8CUX0 (/EXP) P73722 (/EXP) Q9A724 (/EXP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P73722 (/IDA) P9WHR7 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P0A7C2 (/IDA)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 P0A7C2 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P37452 (/IDA)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 P9WHR7 (/IEP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 P0A7C2 (/IMP)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
1 P60511 (/IEP)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
1 P0A7C2 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P0A7C2 (/IMP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P9WHR7 (/IEP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
33 A0A072Z841 (/IDA) A0L9E2 (/IDA) A0QVY5 (/IDA) A1B3Z0 (/IDA) A9BGA3 (/IDA) C1F978 (/IDA) D5ALN0 (/IDA) I6Y1J7 (/IDA) P0A153 (/IDA) P0A7C2 (/IDA)
(23 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
17 A0L9E2 (/EXP) A0QVY5 (/EXP) A1B3Z0 (/EXP) A9BGA3 (/EXP) P0DN68 (/EXP) P59479 (/EXP) P60511 (/EXP) P61608 (/EXP) P73722 (/EXP) Q1D406 (/EXP)
(7 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 A9BGA3 (/IPI) P0A7C2 (/IPI) P0DN68 (/IPI) P60511 (/IPI) P73722 (/IPI) Q1D406 (/IPI) Q6MHM9 (/IPI) Q8F663 (/IPI) Q8YMM5 (/IPI) Q9KVP9 (/IPI)
(1 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 P9WHR7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P0A7C2 (/IDA)