The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 266694: Transcriptional repressor, LexA family

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Repressor LexA. [EC: 3.4.21.88]
Hydrolysis of Ala-|-Gly bond in repressor LexA.
  • In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  • The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37).
  • Belongs to peptidase family S24.
22194 A0A010NL67 A0A010NL67 A0A010NQK3 A0A010NQK3 A0A010PC79 A0A010PC79 A0A010RK41 A0A010RK41 A0A010SNP8 A0A010SNP8
(22184 more...)
Exoribonuclease II. [EC: 3.1.13.1]
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
  • Preference for single-stranded RNA.
  • The enzyme processes 3'-terminal extra-nucleotides of monomeric tRNA precursors, following the action of EC 3.1.26.5.
  • Similar enzymes: RNase Q, RNase BN, RNase PIII, RNase Y.
  • Formerly EC 3.1.4.20.
374 A0A022PNP5 A0A022PNP5 A0A023RPI4 A0A023RPI4 A0A031I8S5 A0A031I8S5 A0A060UTK1 A0A060UTK1 A0A066T6S7 A0A066T6S7
(364 more...)
UDP-glucose 6-dehydrogenase. [EC: 1.1.1.22]
UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
  • Also acts on UDP-2-deoxyglucose.
6 A0A0G0IDA1 A0A0G0IDA1 A0A0G0NF88 A0A0G0NF88 A0A1F8BCC3 A0A1F8BCC3
DNA (cytosine-5-)-methyltransferase. [EC: 2.1.1.37]
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
  • Formerly EC 2.1.1.73.
2 A0A0G0G7R1 A0A0G0G7R1