CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | Alpha/Beta hydrolase fold, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1820 |
| Functional Family | Putative methylesterase 13, chloroplastic |
Enzyme Information
| 4.1.2.47 |
(S)-hydroxynitrile lyase.
based on mapping to UniProt P52704
(1) An aliphatic (S)-hydroxynitrile = cyanide + an aliphatic aldehyde or ketone. (2) An aromatic (S)-hydroxynitrile = cyanide + an aromatic aldehyde.
-!- Hydroxynitrile lyases catalyzes the the cleavage of hydroxynitriles into cyanide and the corresponding aldehyde or ketone. -!- In nature the liberation of cyanide serves as a defense mechanism against herbivores and microbial attack in plants. -!- In vitro the enzymes from Manihot esculenta and Hevea brasiliensis accept a broad range of aliphatic and aromatic carbonyl compounds as substrates and catalyze the formation of (S)-hydroxynitriles. -!- Formerly EC 4.1.2.37 and EC 4.1.2.39.
|
UniProtKB Entries (1)
| P52704 |
HNL_HEVBR
Hevea brasiliensis
(S)-hydroxynitrile lyase
|
PDB Structure
| PDB | 6YAS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Pichia |
| Primary Citation |
Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis.
Protein Sci.
|