CATH Classification

Domain Context

CATH Clusters

Superfamily 2.140.10.30
Functional Family Probable dipeptidyl peptidase 4

Enzyme Information

3.4.14.5
Dipeptidyl-peptidase IV.
based on mapping to UniProt P27487
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487
DPP4_HUMAN
Homo sapiens
Dipeptidyl peptidase 4

PDB Structure

PDB 5ISM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Cox, J.M., Chu, H.D., Kuethe, J.T., Gao, Y.D., Scapin, G., Eiermann, G., He, H., Li, X., Lyons, K.A., Metzger, J., Petrov, A., Wu, J.K., Xu, S., Sinha-Roy, R., Weber, A.E., Biftu, T.
Bioorg.Med.Chem.Lett.