CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.10.2160
Functional Family

Enzyme Information

2.9.1.2
O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
based on mapping to UniProt Q9HD40
O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H(2)O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate.
-!- In archaea and eukarya selenocysteine formation is achieved by a two- step process: EC 2.7.1.164 phosphorylates the endogenous L-seryl- tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase. -!- Formerly EC 2.9.1.n1.

UniProtKB Entries (1)

Q9HD40
SPCS_HUMAN
Homo sapiens
O-phosphoseryl-tRNA(Sec) selenium transferase

PDB Structure

PDB 4ZDP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase.
Puppala, A.K., French, R.L., Matthies, D., Baxa, U., Subramaniam, S., Simonovic, M.
Sci Rep