CATH Classification

Domain Context

CATH Clusters

Superfamily NADH Oxidase
Functional Family Cob(II)yrinic acid a,c-diamide reductase

Enzyme Information

1.21.1.1
Iodotyrosine deiodinase.
based on mapping to UniProt Q6PHW0
L-tyrosine + 2 NADP(+) + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH.
-!- The enzyme activity has only been demonstrated in the direction of 3-deiodination. -!- Formerly EC 1.22.1.1.

UniProtKB Entries (1)

Q6PHW0
IYD1_HUMAN
Homo sapiens
Iodotyrosine deiodinase 1

PDB Structure

PDB 4TTB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Switch between One- and Two-electron Chemistry of the Human Flavoprotein Iodotyrosine Deiodinase Is Controlled by Substrate.
Hu, J., Chuenchor, W., Rokita, S.E.
J.Biol.Chem.