CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Fructose-bisphosphate aldolase 1, chloroplastic

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt Q7KQL9
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

Q7KQL9
ALF_PLAF7
Plasmodium falciparum 3D7
Fructose-bisphosphate aldolase

PDB Structure

PDB 4TR9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
Nemetski, S.M., Cardozo, T.J., Bosch, G., Weltzer, R., O'Malley, K., Ejigiri, I., Kumar, K.A., Buscaglia, C.A., Nussenzweig, V., Sinnis, P., Levitskaya, J., Bosch, J.
Malar.J.