CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.61
5-epiaristolochene synthase.
based on mapping to UniProt Q40577
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate.
-!- Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.

UniProtKB Entries (1)

Q40577
5EAS_TOBAC
Nicotiana tabacum
5-epi-aristolochene synthase

PDB Structure

PDB 4RNQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.
Rising, K.A., Crenshaw, C.M., Koo, H.J., Subramanian, T., Chehade, K.A., Starks, C., Allen, K.D., Andres, D.A., Spielmann, H.P., Noel, J.P., Chappell, J.
Acs Chem.Biol.