CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1410.40
Functional Family

Enzyme Information

2.7.7.86
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8C6L5
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

UniProtKB Entries (1)

Q8C6L5
CGAS_MOUSE
Mus musculus
Cyclic GMP-AMP synthase

PDB Structure

PDB 4O6A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C.A., Zhang, X., Chen, Z.J.
Cell Rep