CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.470 | D-amino Acid Aminotransferase; Chain A, domain 1 |
|
3.30.470.20 | ATP-grasp fold, B domain |
Domain Context
CATH Clusters
| Superfamily | ATP-grasp fold, B domain |
| Functional Family |
Enzyme Information
| 6.3.4.18 |
5-(carboxyamino)imidazole ribonucleotide synthase.
based on mapping to UniProt Q5NGE8
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
-!- In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates. -!- Carboxyphosphate is the putative acyl phosphate intermediate. -!- Involved in the late stages of purine biosynthesis.
|
UniProtKB Entries (1)
| Q5NGE8 |
Q5NGE8_FRATT
Francisella tularensis subsp. tularensis SCHU S4
N5-carboxyaminoimidazole ribonucleotide synthase
|
PDB Structure
| PDB | 4MAM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit of Francisella tularensis subsp. tularensis SCHU S4 in complex with an ADP analog, AMP-CP
To be Published
|