CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family Ribosome-inactivating protein momordin I

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt D9J2T9
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

D9J2T9
D9J2T9_MOMBA
Momordica balsamina
Ribosome inactivating protein

PDB Structure

PDB 4LT4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of arginine inhibited Ribosome inactivating protein from Momordica balsamina at 1.69 A resolution
Yamini, S., Pandey, S., Bhushan, S., Sinha, M., Kaur, P., Sharma, S., Singh, T.P.
To be Published