CATH Classification

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family Probable tRNA sulfurtransferase

Enzyme Information

2.8.1.4
tRNA sulfurtransferase.
based on mapping to UniProt Q9X220
L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide.
-!- A group of enzymes transferring sulfur to various nucleotides in a tRNA chain, producing residues such as 4-thiouridylate. -!- With some enzymes mercaptopyruvate can act as sulfur donor.

UniProtKB Entries (1)

Q9X220
THII_THEMA
Thermotoga maritima MSB8
Probable tRNA sulfurtransferase

PDB Structure

PDB 4KR6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification.
Neumann, P., Lakomek, K., Naumann, P.T., Erwin, W.M., Lauhon, C.T., Ficner, R.
Nucleic Acids Res.