CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.550 | Membrane associated eicosanoid/glutathione metabolism-like domain |
Domain Context
CATH Clusters
| Superfamily | Membrane associated eicosanoid/glutathione metabolism-like domain |
| Functional Family | Microsomal glutathione S-transferase 2 |
Enzyme Information
| 4.4.1.20 |
Leukotriene-C(4) synthase.
based on mapping to UniProt Q16873
Leukotriene C(4) = leukotriene A(4) + glutathione.
-!- The reaction proceeds in the direction of addition. -!- Not identical with EC 2.5.1.18. -!- Formerly EC 2.5.1.37.
|
UniProtKB Entries (1)
| Q16873 |
LTC4S_HUMAN
Homo sapiens
Leukotriene C4 synthase
|
PDB Structure
| PDB | 4J7T |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem.
|