CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic

Enzyme Information

1.3.1.9
Enoyl-[acyl-carrier-protein] reductase (NADH).
based on mapping to UniProt C6KSZ2
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

C6KSZ2
C6KSZ2_PLAF7
Plasmodium falciparum 3D7
Enoyl-acyl carrier reductase

PDB Structure

PDB 4IGE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors of Plasmodium falciparum Enoyl-ACP-reductase (PfFabI)
Belluti, F., Perozzo, R., Lauciello, L., Colizzi, F., Kostrewa, D., Bisi, A., Gobbi, S., Rampa, A., Bolognesi, M.L., Recanatini, M., Brun, R., Scapozza, L., Cavalli, A.
J.Med.Chem.