CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1820
Functional Family Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Enzyme Information

4.2.99.20
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.
based on mapping to UniProt P37355
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.
-!- Involved in the biosynthesis of vitamin K2 (menaquinone). -!- In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. -!- It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9 were carried out by a single enzyme but this has since been disproved. -!- Formerly EC 2.5.1.64 and EC 4.2.99.n1.

UniProtKB Entries (1)

P37355
MENH_ECOLI
Escherichia coli K-12
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

PDB Structure

PDB 4GEG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
Johnston, J.M., Jiang, M., Guo, Z., Baker, E.N.
Plos One