CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.260 | Galactose-binding domain-like |
Domain Context
CATH Clusters
| Superfamily | Galactose-binding domain-like |
| Functional Family | Hyaluronate lyase domain protein |
Enzyme Information
| 4.2.2.1 |
Hyaluronate lyase.
based on mapping to UniProt Q54873
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.
-!- The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction. -!- Also acts on chondroitin. -!- The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. -!- Formerly EC 4.2.99.1.
|
UniProtKB Entries (1)
| Q54873 |
HYSA_STRPN
Streptococcus pneumoniae TIGR4
Hyaluronate lyase
|
PDB Structure
| PDB | 4D0Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Conformational Analysis of the Streptococcus Pneumoniae Hyaluronate Lyase and Characterization of its Hyaluronan-Specific Carbohydrate-Binding Module.
J.Biol.Chem.
|