CATH Domain 4c8bA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Receptor-interacting serine/threonine-protein kinase 2

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt O43353 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2	Non-specific protein-tyrosine kinase. based on mapping to UniProt O43353 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. -!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

RIPK2_HUMAN

Homo sapiens

Receptor-interacting serine/threonine-protein kinase 2

PDB Structure

PDB	4C8B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J.L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P.E., Cuny, G.D., Uhlig, H.H., Gyrd-Hansen, M., Degterev, A., Bullock, A.N. Chem. Biol.