CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.3.1.9
Enoyl-[acyl-carrier-protein] reductase (NADH).
based on mapping to UniProt A0A0E1S3N2
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

A0A0E1S3N2
A0A0E1S3N2_BURPE
Burkholderia pseudomallei 305
Enoyl-[acyl-carrier-protein] reductase [NADH]

PDB Structure

PDB 4BKO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Point Mutation Changes Substrate Binding Mechanism and Inhibitor Specificity of Yersinia Pestis Enoyl- Acp Reductase Fabv
Neckles, C., Hirschbeck, M.W., Shah, S., Pan, P., Bommineni, G.R., Yu, W., Liu, N., Davoodi, S., Kisker, C., Tonge, P.J.
To be Published