CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.300 | GMP Synthetase; Chain A, domain 3 | |
3.30.300.10 |
Domain Context
CATH Clusters
Superfamily | 3.30.300.10 |
Functional Family | GMP synthase [glutamine-hydrolyzing] |
Enzyme Information
6.3.5.2 |
GMP synthase (glutamine-hydrolyzing).
based on mapping to UniProt Q8IJR9
ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
-!- Involved in the de novo biosynthesis of guanosine nucleotides. -!- An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. -!- The enzyme can catalyze the second reaction alone in the presence of ammonia. -!- Formerly EC 6.3.4.1.
|
UniProtKB Entries (1)
Q8IJR9 |
Q8IJR9_PLAF7
Plasmodium falciparum 3D7
GMP synthase [glutamine-hydrolyzing]
|
PDB Structure
PDB | 3UOW |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of PF10_0123, a GMP Synthetase from Plasmodium Falciparum
TO BE PUBLISHED
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