CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.300.10
Functional Family GMP synthase [glutamine-hydrolyzing]

Enzyme Information

6.3.5.2
GMP synthase (glutamine-hydrolyzing).
based on mapping to UniProt Q8IJR9
ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
-!- Involved in the de novo biosynthesis of guanosine nucleotides. -!- An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. -!- The enzyme can catalyze the second reaction alone in the presence of ammonia. -!- Formerly EC 6.3.4.1.

UniProtKB Entries (1)

Q8IJR9
Q8IJR9_PLAF7
Plasmodium falciparum 3D7
GMP synthase [glutamine-hydrolyzing]

PDB Structure

PDB 3UOW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of PF10_0123, a GMP Synthetase from Plasmodium Falciparum
Wernimont, A.K., Dong, A., Hills, T., Amani, M., Perieteanu, A., Lin, Y.H., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Hui, R.
TO BE PUBLISHED