CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.270
Functional Family Diguanylate cyclase YdeH

Enzyme Information

2.7.7.65
Diguanylate cyclase.
based on mapping to UniProt P31129
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.
-!- Can be activated by BeF3, a phosphoryl mimic, which results in dimerization. -!- Dimerization is required but is not sufficient for diguanylate- cyclase activity. -!- Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.

UniProtKB Entries (1)

P31129
YDEH_ECOLI
Escherichia coli K-12
Diguanylate cyclase YdeH

PDB Structure

PDB 3TVK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and signaling mechanism of a zinc-sensory diguanylate cyclase.
Zahringer, F., Lacanna, E., Jenal, U., Schirmer, T., Boehm, A.
Structure