CATH Classification

Domain Context

CATH Clusters

Superfamily 1.25.40.10
Functional Family N-lysine methyltransferase SMYD2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NRG4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9NRG4

UniProtKB Entries (1)

Q9NRG4
SMYD2_HUMAN
Homo sapiens
N-lysine methyltransferase SMYD2

PDB Structure

PDB 3TG4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation
Wang, L., Li, L., Zhang, H., Luo, X., Dai, J., Zhou, S., Gu, J., Zhu, J., Atadja, P., Lu, C., Li, E., Zhao, K.
J.Biol.Chem.