CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Bifunctional protein FolD

Enzyme Information

1.5.1.5
Methylenetetrahydrofolate dehydrogenase (NADP(+)).
based on mapping to UniProt Q05213
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
3.5.4.9
Methenyltetrahydrofolate cyclohydrolase.
based on mapping to UniProt Q05213
5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.

UniProtKB Entries (1)

Q05213
FOLD_THEAC
Thermoplasma acidophilum DSM 1728
Bifunctional protein FolD

PDB Structure

PDB 3NGL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum
Lee, W.H., Sung, M.W., Kim, J.H., Kim, Y.K., Han, A., Hwang, K.Y.
Biochem.Biophys.Res.Commun.