CATH Domain 3mtjA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.360	Dihydrodipicolinate Reductase; domain 2
	3.30.360.10	Dihydrodipicolinate Reductase; domain 2

Domain Context

CATH Clusters

Superfamily	Dihydrodipicolinate Reductase; domain 2
Functional Family	Homoserine dehydrogenase (Hom)

Enzyme Information

1.1.1.3

Homoserine dehydrogenase.

based on mapping to UniProt Q3SKI5

L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.

-!- The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+). -!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4.

UniProtKB Entries (1)

Q3SKI5

Q3SKI5_THIDA

Thiobacillus denitrificans ATCC 25259

Homoserine dehydrogenase

PDB Structure

PDB	3MTJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Crystal Structure of a Homoserine Dehydrogenase from Thiobacillus denitrificans to 2.15A Stein, A.J., Cui, H., Chin, S., Savchenko, A., Joachimiak, A. To be Published